SS18-like protein 1 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in humans is encoded by the ''SS18L1''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Function
Synovial sarcoma
A synovial sarcoma (also known as malignant synovioma) is a rare form of cancer which occurs primarily in the extremities of the arms or legs, often in proximity to joint capsules and tendon sheaths. It is a type of soft-tissue sarcoma.
The name ...
s occur most frequently in the extremities around large joints. More than 90% of cases have a recurrent and specific chromosomal translocation, t(X;18)(p11.2;q11.2), in which the 5-prime end of the
SS18
Protein SSXT is a protein that in humans is encoded by the ''SS18'' gene.
Function
SS18 is a member of the human SWI/SNF chromatin remodeling complex.
Clinical significance
SS18 is involved in a chromosomal translocation commonly found in s ...
gene is fused in-frame to the 3-prime end of the
SSX1,
SSX2, or
SSX4 gene. The SS18L1 gene is homologous to SS18.
Interactions
SS18L1 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with
CREB-binding protein.
Biochemical pull down assays reveal SS18L1 to interact with several components of the human SWI/SNF chromatin remodeling complex.
References
Further reading
*
*
*
*
*
*
*
{{gene-20-stub