SMURF1
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E3 ubiquitin-protein ligase SMURF1 is an
enzyme Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
that in humans is encoded by the ''SMURF1''
gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.


Function

This gene encodes a
ubiquitin ligase A ubiquitin ligase (also called an E3 ubiquitin ligase) is a protein that recruits an E2 ubiquitin-conjugating enzyme that has been loaded with ubiquitin, recognizes a protein substrate, and assists or directly catalyzes the transfer of ubiquitin ...
that is specific for receptor-regulated SMAD proteins in the bone morphogenetic protein ( BMP) pathway. A similar protein in ''
Xenopus ''Xenopus'' () (Gk., ξενος, ''xenos''=strange, πους, ''pous''=foot, commonly known as the clawed frog) is a genus of highly aquatic frogs native to sub-Saharan Africa. Twenty species are currently described within it. The two best-known ...
'' is involved in embryonic pattern formation. Alternative splicing results in multiple transcript variants encoding different isoforms. An additional transcript variant has been identified, but its full length sequence has not been determined.


Interactions

SMURF1 has been shown to
interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with: *
ARHGEF9 Rho guanine nucleotide exchange factor 9 is a protein that in humans is encoded by the ''ARHGEF9'' gene. Function ARHGEF9 belongs to a family of Rho-like GTPases that act as molecular switches by cycling from the active GTP-bound state to the ...
, *
PLEKHO1 Pleckstrin homology domain-containing family O member 1 is a protein that in humans is encoded by the ''PLEKHO1'' gene. Interactions PLEKHO1 has been shown to interact with Casein kinase 2, alpha 1 and SMURF1 E3 ubiquitin-protein ligase SMU ...
, and *
SMURF2 E3 ubiquitin-protein ligase SMURF2 is an enzyme that in humans is encoded by the ''SMURF2'' gene which is located at chromosome 17q23.3-q24.1. Interactions SMURF2 has been shown to interact with: * Mothers against decapentaplegic homolog 1, * ...
.


References


Further reading

* * * * * * * * * * * * * *


External links

* {{protein-stub