{{Unreferenced, date=June 2019, bot=noref (GreenC bot)
A protein mimetic is a molecule such as a
peptide
Peptides (, ) are short chains of amino acids linked by peptide bonds. Long chains of amino acids are called proteins. Chains of fewer than twenty amino acids are called oligopeptides, and include dipeptides, tripeptides, and tetrapeptides.
A ...
, a modified peptide or any other molecule that biologically mimics the action or activity of some other
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
.
Protein mimetics are commonly used in
drug design
Drug design, often referred to as rational drug design or simply rational design, is the inventive process of finding new medications based on the knowledge of a biological target. The drug is most commonly an organic small molecule that acti ...
and
discovery
Discovery may refer to:
* Discovery (observation), observing or finding something unknown
* Discovery (fiction), a character's learning something unknown
* Discovery (law), a process in courts of law relating to evidence
Discovery, The Discovery ...
.
Types of mimetics
There are a number of different distinct classes of protein mimetics.
*
Antibody mimetic Antibody mimetics are organic compounds that, like antibodies, can specifically bind antigens, but that are not structurally related to antibodies. They are usually artificial peptides or proteins with a molar mass of about 3 to 20 kDa. (Antibo ...
- Molecules that mimic antigen binding activity of antibodies
*
Peptidomimetic
A peptidomimetic is a small protein-like chain designed to mimic a peptide. They typically arise either from modification of an existing peptide, or by designing similar systems that mimic peptides, such as peptoids and Beta-peptide, β-peptides. ...
- Small protein-like chains designed to mimic larger peptide.
* Phosphomimetics - An amino acid substitution or
modification
Modification may refer to:
* Modifications of school work for students with special educational needs
* Modifications (genetics), changes in appearance arising from changes in the environment
* Posttranslational modifications, changes to protein ...
which mimic the effect of
protein phosphorylation
Protein phosphorylation is a reversible post-translational modification of proteins in which an amino acid residue is phosphorylated by a protein kinase by the addition of a covalently bound phosphate group. Phosphorylation alters the structural ...
.
See also
*
Homology (biology)
In biology, homology is similarity due to shared ancestry between a pair of structures or genes in different taxa. A common example of homologous structures is the forelimbs of vertebrates, where the wings of bats and birds, the arms of pri ...