Plomestane (, ; former developmental code name MDL-18962; also known as propargylestrenedione, PED) is a

steroid A steroid is a biologically active organic compound with four rings arranged in a specific molecular configuration. Steroids have two principal biological functions: as important components of cell membranes that alter membrane fluidity; and a ...

al, irreversible aromatase inhibitor which was under development by Marion Merrell Dow/ Hoechst Marion Russell (now Hoechst AG) as an antineoplastic agent for the treatment of

breast cancer Breast cancer is cancer that develops from breast tissue. Signs of breast cancer may include a lump in the breast, a change in breast shape, dimpling of the skin, milk rejection, fluid coming from the nipple, a newly inverted nipple, or a re ...

. It was found to be effective in preclinical studies and was also found to produce few

adverse effect An adverse effect is an undesired harmful effect resulting from a medication or other intervention, such as surgery. An adverse effect may be termed a "side effect", when judged to be secondary to a main or therapeutic effect. The term complica ...

s in human

clinical trial Clinical trials are prospective biomedical or behavioral research studies on human participants designed to answer specific questions about biomedical or behavioral interventions, including new treatments (such as novel vaccines, drugs, dietar ...

s, significantly reducing

estrogen Estrogen or oestrogen is a category of sex hormone responsible for the development and regulation of the female reproductive system and secondary sex characteristics. There are three major endogenous estrogens that have estrogenic hormonal acti ...

levels with a single administration. However, development of the drug for clinical use was halted due to "technical issues" and it was never marketed. In addition to its activity as an aromatase inhibitor, plomestane has weak androgenic properties.

References

Anabolic–androgenic steroids Androstanes Antiestrogens Aromatase inhibitors Hormonal antineoplastic drugs Propargyl compounds {{Antineoplastic-drug-stub

See also

References