Peter Walter (born December 5, 1954) is a German-American

molecular biologist Molecular biology is the branch of biology that seeks to understand the molecular basis of biological activity in and between cells, including biomolecular synthesis, modification, mechanisms, and interactions. The study of chemical and physi ...

and

biochemist Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and Cell (biology), cell parts. The word "biochemist" is a portmanteau of ...

and is Director of the Bay Area Institute of Science at

Altos Labs Altos Labs, Inc. is an American biotechnology research company. Altos Labs' goal is to develop life extension therapies that can halt or reverse the human aging process. Specialized cell therapies based on induced pluripotent stem cells are to ...

, Professor at the

University of California, San Francisco The University of California, San Francisco (UCSF) is a public land-grant research university in San Francisco, California. It is part of the University of California system and is dedicated entirely to health science and life science. It cond ...

(UCSF). He was a

Howard Hughes Medical Institute The Howard Hughes Medical Institute (HHMI) is an American non-profit medical research organization based in Chevy Chase, Maryland. It was founded in 1953 by Howard Hughes, an American business magnate, investor, record-setting pilot, engineer, fil ...

(HHMI) Investigator until 2022.

Education

Peter attended the

Freie Universität Berlin The Free University of Berlin (, often abbreviated as FU Berlin or simply FU) is a public research university in Berlin, Germany. It is consistently ranked among Germany's best universities, with particular strengths in political science and t ...

, received his MS in Organic Chemistry from

Vanderbilt University Vanderbilt University (informally Vandy or VU) is a private research university in Nashville, Tennessee. Founded in 1873, it was named in honor of shipping and rail magnate Cornelius Vanderbilt, who provided the school its initial $1-million ...

in 1977 and his PhD in Cell Biology at

The Rockefeller University The Rockefeller University is a private biomedical research and graduate-only university in New York City, New York. It focuses primarily on the biological and medical sciences and provides doctoral and postdoctoral education. It is classif ...

in 1981.

Career

During his thesis work in Dr.

Günter Blobel Günter Blobel (; May 21, 1936 – February 18, 2018) was a Silesian German and American biologist and 1999 Nobel Prize laureate in Physiology for the discovery that proteins have intrinsic signals that govern their transport and localization in ...

's laboratory, Walter purified the proteinaceous members of a macromolecular complex essential for protein translocation into the

endoplasmic reticulum The endoplasmic reticulum (ER) is, in essence, the transportation system of the eukaryotic cell, and has many other important functions such as protein folding. It is a type of organelle made up of two subunits – rough endoplasmic reticulum ( ...

(ER) and showed that it selectively recognizes nascent secretory proteins in the cytoplasm of eukaryotic cells and targets them to the ER. He subsequently identified a 7S RNA component of the complex which is essential for its function and named the holocomplex the

signal recognition particle The signal recognition particle (SRP) is an abundant, cytosolic, universally conserved ribonucleoprotein (protein-RNA complex) that recognizes and targets specific proteins to the endoplasmic reticulum in eukaryotes and the plasma membrane ...

(SRP). Walter moved from Rockefeller to start his own laboratory at the University of California, San Francisco. He and his group identified an ER resident transmembrane kinase/endoribonuclease, Ire1, which is one of three known sensors of the folding capacity within the endoplasmic reticulum lumen responsible for initiating a signaling pathway known as the

unfolded protein response The unfolded protein response (UPR) is a cellular stress response related to the endoplasmic reticulum (ER) stress. It has been found to be conserved between all mammalian species, as well as yeast and worm organisms. The UPR is activated in resp ...

. Walter's laboratory at UCSF continues to focus on gaining a mechanistic understanding of protein sorting/targeting to the ER as well as a better understanding the interplay between ER homeostasis and disease. Walter describes his career as "Walking Along the Serendipitous Path of Discovery" and goes on to say "Personally, I would consider it a crowning highlight of my career if some aspects of the basic knowledge that we have accumulated over the years are translated into a tangible benefit for mankind. Yet importantly, none of these tremendous opportunities were obvious when we started on our journey; they only emerged gradually as we playfully and fervently followed the turns of our meandering and serendipitous path."

Awards and honors

Walter is an elected member of the

National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nati ...

American Academy of Arts and Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and ...

, the

National Academy of Medicine The National Academy of Medicine (NAM), formerly called the Institute of Medicine (IoM) until 2015, is an American nonprofit, non-governmental organization. The National Academy of Medicine is a part of the National Academies of Sciences, En ...

, and the

National Academy of Inventors The National Academy of Inventors (NAI) is a US non-profit organization dedicated to encouraging inventors in academia, following the model of the National Academies of the United States. It was founded at the University of South Florida in 2010. ...

. His recent awards include the 2014 Shaw Prize in Life Science and Medicine, the 2014

Lasker Award The Lasker Awards have been awarded annually since 1945 to living persons who have made major contributions to medical science or who have performed public service on behalf of medicine. They are administered by the Lasker Foundation, which was f ...

for Basic Medical Research, the 2015

Vilcek Prize The Vilcek Foundation raises awareness of immigrant contributions to the United States, and fosters appreciation of the arts and sciences. The foundation's flagship programs include the Vilcek Foundation Prizes, which recognize and support immigra ...

in Biomedical Science, the 2018

Breakthrough Prize in Life Sciences The Breakthrough Prize in Life Sciences is a scientific award, funded by internet entrepreneurs Mark Zuckerberg and Priscilla Chan of Facebook; Sergey Brin of Google; entrepreneur and venture capitalist Yuri Milner; and Anne Wojcicki, one of the ...

, and 2020 UCSF Lifetime Achievement in Mentoring Award. Walter is a coauthor of the textbook

Molecular Biology of the Cell ''Molecular Biology of the Cell'' is a biweekly peer-reviewed scientific journal published by the American Society for Cell Biology. It covers research on the molecular basis of cell structure and function. According to the ''Journal Citation Rep ...

References

External links

* {{DEFAULTSORT:Walter, Peter 1954 births Living people American molecular biologists 21st-century American biologists German molecular biologists Howard Hughes Medical Investigators Members of the United States National Academy of Sciences University of California, San Francisco faculty Rockefeller University alumni Free University of Berlin alumni Recipients of the Albert Lasker Award for Basic Medical Research Members of the National Academy of Medicine