DNA-directed RNA polymerase II subunit RPB3 is an

enzyme Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...

that in humans is encoded by the ''POLR2C''

gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...

Function

This gene encodes the third largest subunit of

RNA polymerase II RNA polymerase II (RNAP II and Pol II) is a multiprotein complex that transcribes DNA into precursors of messenger RNA (mRNA) and most small nuclear RNA (snRNA) and microRNA. It is one of the three RNAP enzymes found in the nucleus of eukaryoti ...

, the polymerase responsible for synthesizing messenger

RNA Ribonucleic acid (RNA) is a polymeric molecule essential in various biological roles in coding, decoding, regulation and expression of genes. RNA and deoxyribonucleic acid ( DNA) are nucleic acids. Along with lipids, proteins, and carbohydra ...

in eukaryotes. The product of this gene contains a cysteine rich region and exists as a heterodimer with another polymerase subunit,

POLR2J DNA-directed RNA polymerase II subunit RPB11-a is an enzyme that in humans is encoded by the ''POLR2J'' gene. Function This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. Th ...

. These two subunits form a core subassembly unit of the polymerase. A

pseudogene Pseudogenes are nonfunctional segments of DNA that resemble functional genes. Most arise as superfluous copies of functional genes, either directly by DNA duplication or indirectly by Reverse transcriptase, reverse transcription of an mRNA trans ...

has been identified on chromosome 21.

Interactions

POLR2C has been shown to

interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...

with: *

ATF4 Activating transcription factor 4 (tax-responsive enhancer element B67), also known as ATF4, is a protein that in humans is encoded by the ''ATF4'' gene. Function This gene encodes a transcription factor that was originally identified as a wi ...

, *

CCHCR1 Coiled-coil alpha-helical rod protein 1, also known as CCHCR1, is a protein which in humans is encoded by the ''CCHCR1'' gene. Gene The Human CCHCR1 gene is located at 6p21.33. It is also known as Coiled-Coil Alphahelical Rod Protein 1, C6orf18 ...

, *

Myogenin Myogenin, is a transcriptional activator encoded by the MYOG gene. Myogenin is a muscle-specific basic-helix-loop-helix (bHLH) transcription factor involved in the coordination of skeletal muscle development or myogenesis and repair. Myogenin is ...

, *

POLR2A DNA-directed RNA polymerase II subunit RPB1, also known as RPB1, is an enzyme that in humans is encoded by the ''POLR2A'' gene. Function This gene encodes the largest subunit of RNA polymerase II, the polymerase responsible for synthesizing me ...

, *

POLR2B DNA-directed RNA polymerase II subunit RPB2 is an enzyme that in humans is encoded by the ''POLR2B'' gene. This gene encodes the second largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. ...

, *

POLR2E DNA-directed RNA polymerases I, II, and III subunit RPABC1 is a protein that in humans is encoded by the ''POLR2E'' gene. This gene encodes the fifth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA ...

and *

POLR2F DNA-directed RNA polymerases I, II, and III subunit RPABC2 is a protein that in humans is encoded by the ''POLR2F'' gene. This gene encodes the sixth largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA i ...

, *

POLR2G DNA-directed RNA polymerase II subunit RPB7 is an enzyme that in humans is encoded by the ''POLR2G'' gene. This gene encodes the seventh largest subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. ...

, *

POLR2H DNA-directed RNA polymerases I, II, and III subunit RPABC3 is a protein that in humans is encoded by the ''POLR2H'' gene. This gene encodes one of the essential subunits of RNA polymerase II that is shared by the other two eukaryotic DNA-directed ...

, *

POLR2K DNA-directed RNA polymerases I, II, and III subunit RPABC4 is a protein that in humans is encoded by the ''POLR2K'' gene. This gene encodes one of the smallest subunits of RNA polymerase II, the polymerase responsible for synthesizing messenger R ...

, *

POLR2L DNA-directed RNA polymerases I, II, and III subunit RPABC5 is a protein that in humans is encoded by the ''POLR2L'' gene. Function This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in e ...

, and *

TAF15 TATA-binding protein-associated factor 2N is a protein that in humans is encoded by the ''TAF15'' gene. Function Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates ...

Function

Interactions

References

Further reading