Origin recognition complex subunit 2 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that is encoded by the ORC2 (ORC2L)
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
in humans.
Function
The
origin recognition complex
In molecular biology, origin recognition complex (ORC) is a multi-subunit DNA binding complex (6 subunits) that binds in all eukaryotes and archaea in an ATP-dependent manner to origins of replication. The subunits of this complex are encoded ...
(ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as
Cdc6
Cell division control protein 6 homolog is a protein that in humans is encoded by the ''CDC6'' gene.
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. ...
and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. This protein forms a core complex with
ORC3
Origin recognition complex subunit 3 is a protein that in humans is encoded by the ORC3 (ORC3L) gene.
Function
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA repl ...
,
ORC4
Origin recognition complex subunit 4 is a protein that in humans is encoded by the ORC4 (ORC4L) gene.
Function
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replic ...
, and
ORC5
Origin recognition complex subunit 5 is a protein that in humans is encoded by the ORC5 (ORC5L) gene.
Function
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replic ...
. It also interacts with
CDC45L
CDC45 is a protein that in humans is encoded by the ''CDC45L'' gene.
Function
The protein encoded by this gene was identified by its strong similarity with Saccharomyces cerevisiae Cdc45, an essential protein required to the initiation of DNA r ...
and MCM10, which are proteins known to be important for the initiation of DNA replication. This protein has been demonstrated to specifically associate with the origin of replication of Epstein-Barr virus in human cells, and is thought to be required for DNA replication from viral origin of replication.
Interactions
ORC2 has been shown to
interact
Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with:
*
CDC6
Cell division control protein 6 homolog is a protein that in humans is encoded by the ''CDC6'' gene.
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. ...
,
DBF4
Protein DBF4 homolog A is a protein that is encoded by the ''DBF4'' gene in humans.
Interactions
DBF4 has been shown to interact with:
* Cell division cycle 7-related protein kinase,
* MCM3,
* MCM7,
* ORC2L, and
* ORC6L
Origin recogniti ...
,[
* ]MCM10
Protein MCM10 homolog is a protein that in humans is encoded by the ''MCM10'' gene. It is essential for activation of the Cdc45: Mcm2-7:GINS helicase, and thus required for proper DNA replication.
Function
The protein encoded by this gene is o ...
,MCM2
DNA replication licensing factor MCM2 is a protein that in humans is encoded by the ''MCM2'' gene.
Function
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the ini ...
[
* ]MCM4
DNA replication licensing factor MCM4 is a protein that in humans is encoded by the ''MCM4'' gene.
Function
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the i ...
,[
* ]MCM5
DNA replication licensing factor MCM5 is a protein that in humans is encoded by the ''MCM5'' gene.
Function
The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiat ...
,[
* ]MCM6
DNA replication licensing factor MCM6 is a protein that in humans is encoded by the ''MCM6'' gene. MCM6 is one of the highly conserved mini-chromosome maintenance proteins ( MCM) that are essential for the initiation of eukaryotic genome replicati ...
,[
* ]MCM7
DNA replication licensing factor MCM7 is a protein that in humans is encoded by the ''MCM7'' gene.
Function
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the in ...
,[
* ]ORC1
Origin recognition complex subunit 1 is a protein that in humans is encoded by the ORC1 gene. It is closely related to CDC6, and both are the same protein in archaea.
Function
The origin recognition complex (ORC) is a highly conserved six subu ...
,ORC3
Origin recognition complex subunit 3 is a protein that in humans is encoded by the ORC3 (ORC3L) gene.
Function
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA repl ...
,ORC4
Origin recognition complex subunit 4 is a protein that in humans is encoded by the ORC4 (ORC4L) gene.
Function
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replic ...
,ORC5
Origin recognition complex subunit 5 is a protein that in humans is encoded by the ORC5 (ORC5L) gene.
Function
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replic ...
,ORC6
Origin recognition complex subunit 6 is a protein that in humans is encoded by the ORC6 (ORC6L) gene.
Background
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA repli ...
,[ and
* ]Replication protein A1
Replication protein A 70 kDa DNA-binding subunit is a protein that in humans is encoded by the ''RPA1'' gene.
Interactions
Replication protein A1 has been shown to interact with:
* BRCA2,
* BLM,
* MCM2,
* MCM4,
* MCM6,
* MCM7,
* MUTYH,
* ...
.[
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References
Further reading
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{{Refend
External links
PDBe-KB
provides an overview of all the structure information available in the PDB for Human Origin recognition complex subunit 2 (ORC2)