O-4310 (1-isopropyl-6-fluoro-psilocin) is a
tryptamine derivative developed by
Organix Inc which acts as a
serotonin receptor
5-HT receptors, 5-hydroxytryptamine receptors, or serotonin receptors, are a group of G protein-coupled receptor and ligand-gated ion channels found in the central and peripheral nervous systems. They mediate both excitatory and inhibitory neur ...
agonist
An agonist is a chemical that activates a receptor to produce a biological response. Receptors are cellular proteins whose activation causes the cell to modify what it is currently doing. In contrast, an antagonist blocks the action of the ago ...
. It is claimed to have an EC
50 of 5nM at
5-HT2A with 89% efficacy vs
5-HT
Serotonin () or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter. Its biological function is complex and multifaceted, modulating mood, cognition, reward, learning, memory, and numerous physiological processes such as vomiting and vas ...
, and 100x selectivity over
5-HT2C, while being apparently inactive at the
5-HT2B antitarget.
See also
*
1-Methylpsilocin
1-Methylpsilocin is a tryptamine derivative which acts as a selective agonist for the 5-HT2C receptor (IC50 of 12 nM, vs 633 nM at 5-HT2A), and an inverse agonist at 5-HT2B (Ki of 38 nM). While 1-methylpsilocin does have higher ...
*
5-Fluoro-DMT
5-Fluoro-''N'',''N''-dimethyltryptamine (5-fluoro-DMT, 5F-DMT) is a tryptamine derivative related to compounds such as 5-bromo-DMT and 5-MeO-DMT. Fluorination of psychedelic tryptamines either reduces or has little effect on 5-HT2A/C receptor af ...
*
Psilocin
*
SCHEMBL5334361
*
7F-5-MeO-MET
References
Tryptamines
Fluoroarenes
Isopropyl compounds
Dimethylamino compounds
Phenols
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