Miguel Rolando Covian
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Miguel Rolando Covian (September 7, 1913 – February 5, 1992), was an Argentine-
Brazil Brazil ( pt, Brasil; ), officially the Federative Republic of Brazil (Portuguese: ), is the largest country in both South America and Latin America. At and with over 217 million people, Brazil is the world's fifth-largest country by area ...
ian physiologist, medical educator and writer.


Biography


Early life and education

Covian was born in Rufino,
Santa Fe Province The Province of Santa Fe ( es, Provincia de Santa Fe, ) is a province of Argentina, located in the center-east of the country. Neighboring provinces are from the north clockwise Chaco (divided by the 28th parallel south), Corrientes, Entre RÃ ...
,
Argentina Argentina (), officially the Argentine Republic ( es, link=no, República Argentina), is a country in the southern half of South America. Argentina covers an area of , making it the second-largest country in South America after Brazil, th ...
, on September 7, 1913. He studied at the Faculty of Medicine of the
University of Buenos Aires The University of Buenos Aires ( es, Universidad de Buenos Aires, UBA) is a public research university in Buenos Aires, Argentina. Established in 1821, it is the premier institution of higher learning in the country and one of the most prestigi ...
, where, while a student, he worked also as a teaching assistant in the Chair of
Physiology Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemical ...
. He graduated in 1942 and soon thereafter started a full-time career in research on Physiology, initially in collaboration with Bernardo Houssay, the great Argentine physiologist, who later was awarded with the 1947
Nobel Prize The Nobel Prizes ( ; sv, Nobelpriset ; no, Nobelprisen ) are five separate prizes that, according to Alfred Nobel's will of 1895, are awarded to "those who, during the preceding year, have conferred the greatest benefit to humankind." Alfr ...
in Medicine and Physiology for his investigations on the interaction between the hypophysis and the
pancreas The pancreas is an organ of the digestive system and endocrine system of vertebrates. In humans, it is located in the abdomen behind the stomach and functions as a gland. The pancreas is a mixed or heterocrine gland, i.e. it has both an en ...
in the control of
glucose Glucose is a simple sugar with the molecular formula . Glucose is overall the most abundant monosaccharide, a subcategory of carbohydrates. Glucose is mainly made by plants and most algae during photosynthesis from water and carbon dioxide, u ...
metabolism Metabolism (, from el, μεταβολή ''metabolē'', "change") is the set of life-sustaining chemical reactions in organisms. The three main functions of metabolism are: the conversion of the energy in food to energy available to run c ...
. From 1945 to 1948, Covian worked at the Institute of Experimental Biology and Medicine of Buenos Aires, a private research institution which Houssay and co-workers had founded in 1944, due to his dismissal from the University due to political persecution by the dictatorial regime of Juan Perón. There, he worked also with another eminent physiologist,
Eduardo Braun-Men̩ndez Eduardo Braun-Men̩ndez (January 16, 1903 РJanuary 16, 1959) was a noted Argentine physiologist. Life and work Born in Punta Arenas, Chile, he was a naturalized Argentine citizen from a very early age, and was raised in Buenos Aires.
, and presented his doctoral dissertation in 1948.


Fellowship

After his doctorate Covian went for a post-doctoral fellowship by the Rockefeller Foundation, at the
Johns Hopkins University Johns Hopkins University (Johns Hopkins, Hopkins, or JHU) is a private research university in Baltimore, Maryland. Founded in 1876, Johns Hopkins is the oldest research university in the United States and in the western hemisphere. It consi ...
,
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,
United States The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country primarily located in North America. It consists of 50 states, a federal district, five major unincorporated territori ...
. There he worked on the physiology of hemidecorticated animals and neurovegetative control, with several important physiologists, such as
Phillip Bard Philip, also Phillip, is a male given name, derived from the Greek (''Philippos'', lit. "horse-loving" or "fond of horses"), from a compound of (''philos'', "dear", "loved", "loving") and (''hippos'', "horse"). Prominent Philips who popularize ...
, Carl Richter and
Vernon Mountcastle Vernon Benjamin Mountcastle (July 15, 1918 – January 11, 2015) was an American neurophysiologist and Professor Emeritus of Neuroscience at Johns Hopkins University. He discovered and characterized the columnar organization of the cerebral co ...
. He returned three years later to Argentina, to continue his participation at the Institute of Experimental Biology and Medicine, where, in 1952, he established the first experimental laboratory of
neurophysiology Neurophysiology is a branch of physiology and neuroscience that studies nervous system function rather than nervous system architecture. This area aids in the diagnosis and monitoring of neurological diseases. Historically, it has been dominated b ...
of Argentina.


Research

In 1955 Covian was already well known internationally for his research on the neurophysiology of the limbic system. He accepted an invitation from Dr. Zeferino Vaz to join the faculty of the recently founded School of Medicine of Ribeirão Preto of the
University of São Paulo The University of São Paulo ( pt, Universidade de São Paulo, USP) is a public university in the Brazilian state of São Paulo. It is the largest Brazilian public university and the country's most prestigious educational institution, the bes ...
, at
Ribeirão Preto Ribeirão Preto (Portuguese pronunciation: ibejˈɾÉ̃w ˈpɾetu is a municipality and a metropolitan area located in the northeastern region of São Paulo state, Brazil. Ribeirão Preto is the eighth-largest municipality in the State wit ...
,
São Paulo São Paulo (, ; Portuguese for ' Saint Paul') is the most populous city in Brazil, and is the capital of the state of São Paulo, the most populous and wealthiest Brazilian state, located in the country's Southeast Region. Listed by the Ga ...
,
Brazil Brazil ( pt, Brasil; ), officially the Federative Republic of Brazil (Portuguese: ), is the largest country in both South America and Latin America. At and with over 217 million people, Brazil is the world's fifth-largest country by area ...
, as the chairman of the Department of Physiology, a post he held until 1974 and from 1978 to 1982. Under Covian's able and humane
leadership Leadership, both as a research area and as a practical skill, encompasses the ability of an individual, group or organization to "lead", influence or guide other individuals, teams, or entire organizations. The word "leadership" often gets vi ...
, the Department would grow to become one of the main excellence centers of research and education in
Latin America Latin America or * french: Amérique Latine, link=no * ht, Amerik Latin, link=no * pt, América Latina, link=no, name=a, sometimes referred to as LatAm is a large cultural region in the Americas where Romance languages — languages derived f ...
, with an excellent scientific staff, with prominent researchers such as Eduardo Krieger, Renato Migliorini, César Timo-Iaria, José Antunes Rodrigues, José Venâncio Pereira Leite and fellow Argentines Maria Carmelo Lico, Andrés Negro-Vilar and Ricardo F. Marseillan. Covian was involved in all aspects of scientific and educational progress in the physiological sciences. It was there too that Covian founded the first Brazilian laboratory of neurophysiology.


Leadership

Covian was extremely active as a scientific leader. He was one of the founders and a president of the Brazilian Society of Physiology. He also was a strong force behind the graduate programs of the School of Medicine of Ribeirão Preto, and an innovator in the use of new approaches to the teaching of physiology. He was active in the editorial boards of several international scientific journals, such as "Physiology & Behavior" and the monograph series of " Progress in Brain Research", a member to several international committees, the
International Brain Research Organization The International Brain Research Organization (IBRO) is the global federation of neuroscience organizations that aims to promote and support neuroscience around the world through training, teaching, collaborative research, advocacy and outreach. M ...
and the Latin American Federation of Physiological Sciences.


Systematic study

Covian's main achievement in neurophysiology was the systematic study, with a large group of collaborators, of the neural basis of
thirst Thirst is the craving for potable fluids, resulting in the basic instinct of animals to drink. It is an essential mechanism involved in fluid balance. It arises from a lack of fluids or an increase in the concentration of certain osmolites, suc ...
, of
neuroendocrine Neuroendocrine cells are cells that receive neuronal input (through neurotransmitters released by nerve cells or neurosecretory cells) and, as a consequence of this input, release messenger molecules (hormones) into the blood. In this way they bri ...
regulation of hydroelectrolytic
homeostasis In biology, homeostasis (British also homoeostasis) (/hɒmɪə(ʊ)ˈsteɪsɪs/) is the state of steady internal, physical, and chemical conditions maintained by living systems. This is the condition of optimal functioning for the organism and ...
, and of appetitive behavior, i.e., the behavior which permit animals to seek and to ingest particular foodstuffs or
diet Diet may refer to: Food * Diet (nutrition), the sum of the food consumed by an organism or group * Dieting, the deliberate selection of food to control body weight or nutrient intake ** Diet food, foods that aid in creating a diet for weight loss ...
components, an activity which depends on many external and internal factors. The
animal model An animal model (short for animal disease model) is a living, non-human, often genetic-engineered animal used during the research and investigation of human disease, for the purpose of better understanding the disease process without the risk of ha ...
used by Covian's group was the selective ingestion of
water Water (chemical formula ) is an Inorganic compound, inorganic, transparent, tasteless, odorless, and Color of water, nearly colorless chemical substance, which is the main constituent of Earth's hydrosphere and the fluids of all known living ...
versus
salt water Saline water (more commonly known as salt water) is water that contains a high concentration of dissolved salts (mainly sodium chloride). On the United States Geological Survey (USGS) salinity scale, saline water is saltier than brackish wat ...
in albino Norwegian rats, which they investigated with many approaches and tools, such as after lesions and stimulations of the
central nervous system The central nervous system (CNS) is the part of the nervous system consisting primarily of the brain and spinal cord. The CNS is so named because the brain integrates the received information and coordinates and influences the activity of all p ...
, measurement of metabolic activity, manipulation of the activity of the
endocrine system The endocrine system is a messenger system comprising feedback loops of the hormones released by internal glands of an organism directly into the circulatory system, regulating distant target organs. In vertebrates, the hypothalamus is the neu ...
, the effect of several kinds of drugs, etc. He also studied the role of the limbic system (particularly the
septal area The septal area (medial olfactory area), consisting of the lateral septum and medial septum, is an area in the lower, posterior part of the medial surface of the frontal lobe, and refers to the nearby septum pellucidum. The septal nuclei are loca ...
) on many behaviors and functions, such as the control of blood pressure, the neuroendocrine regulation of
reproductive behavior Reproduction (or procreation or breeding) is the biological process by which new individual organisms – "offspring" – are produced from their "parent" or parents. Reproduction is a fundamental feature of all known life; each individual org ...
, etc.


Humanist

Covian was also a
humanist Humanism is a philosophical stance that emphasizes the individual and social potential and agency of human beings. It considers human beings the starting point for serious moral and philosophical inquiry. The meaning of the term "human ...
, deeply interested in the
history History (derived ) is the systematic study and the documentation of the human activity. The time period of event before the invention of writing systems is considered prehistory. "History" is an umbrella term comprising past events as well ...
and
philosophy of science Philosophy of science is a branch of philosophy concerned with the foundations, methods, and implications of science. The central questions of this study concern what qualifies as science, the reliability of scientific theories, and the ult ...
,
history of medicine The history of medicine is both a study of medicine throughout history as well as a multidisciplinary field of study that seeks to explore and understand medical practices, both past and present, throughout human societies. More than just histo ...
,
epistemology Epistemology (; ), or the theory of knowledge, is the branch of philosophy concerned with knowledge. Epistemology is considered a major subfield of philosophy, along with other major subfields such as ethics, logic, and metaphysics. Epis ...
,
religion Religion is usually defined as a social- cultural system of designated behaviors and practices, morals, beliefs, worldviews, texts, sanctified places, prophecies, ethics, or organizations, that generally relates humanity to supernatural, ...
, classical music and erudite
art Art is a diverse range of human activity, and resulting product, that involves creative or imaginative talent expressive of technical proficiency, beauty, emotional power, or conceptual ideas. There is no generally agreed definition of wha ...
. He retired at the mandatory age of 70, as a
professor emeritus ''Emeritus'' (; female: ''emerita'') is an adjective used to designate a retired chair, professor, pastor, bishop, pope, director, president, prime minister, rabbi, emperor, or other person who has been "permitted to retain as an honorary title ...
, but continued to appear regularly his office in the department


Death

Honored by his many colleagues, pupils and friends, Covian died on February 5, 1992, following complications of a stroke.


Bibliography

* Covian, MR: Studies on the neurovegetative and behavioral functions of the brain septal area. ''Prog Brain Res.'' 1967;27:189-217. * Covian, MR: ''Fisiologia del Ãrea Septal''. Conferéncias Eduardo Braun Menéndez. Buenos Aires, 1967.


References


External links

* Vicchi, F.L.
O Professor Miguel Rolando Covian
''USP Ribeirão Preto'', Newsletter No. 748, 2002 (In Portuguese).
Interview with Miguel Covian
Center for Logics and Epistemology. State University of Campinas (In Portuguese) {{DEFAULTSORT:Covian, Miguel Rolando 1913 births 1992 deaths People from General López Department Argentine physiologists Argentine emigrants to Brazil Brazilian neuroscientists Brazilian physiologists Johns Hopkins University faculty University of São Paulo faculty Expatriate academics in Brazil