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NM_198205
NM_170607
NM_198204

NM_001159384
NM_001159385
NM_011550

RefSeq (protein)

NP_733752
NP_937847
NP_937848

NP_001152856
NP_001152857
NP_035680

Location (UCSC) Chr 17: 42.57 – 42.57 Mb Chr 11: 101.09 – 101.09 Mb PubMed search [3] [4] Wikidata
View/Edit Human View/Edit Mouse

Max-like protein X is a protein that in humans is encoded by the MLX gene.[5][6]

Function

The product of this gene belongs to the family of basic helix-loop-helix leucine zipper (bHLH-Zip) transcription factors. These factors form heterodimers with Mad proteins and play a role in proliferation, determination and differentiation. This gene product may act to diversify Mad family function by its restricted association with a subset of the Mad family of transcriptional repressors, namely Mad1 and Mad4. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene.[6]

Interactions

MLX (gene) has been shown to interact with MNT,[7][8] MXD1[7][8] and MLXIPL.[7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000108788 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000017801 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". 
  4. ^ "Mouse PubMed Reference:". 
  5. ^ Bjerknes M, Cheng H (November 1996). "TCFL4: a gene at 17q21.1 encoding a putative basic helix-loop-helix leucine-zipper transcription factor". Gene. 181 (1–2): 7–11. doi:10.1016/S0378-1119(96)00376-9. PMID 8973301. 
  6. ^ a b "Entrez Gene: MLX MAX-like protein X". 
  7. ^ a b c Cairo S, Merla G, Urbinati F, Ballabio A, Reymond A (March 2001). "WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network". Human Molecular Genetics. 10 (6): 617–27. doi:10.1093/hmg/10.6.617. PMID 11230181. 
  8. ^ a b Meroni G, Cairo S, Merla G, Messali S, Brent R, Ballabio A, Reymond A (July 2000). "Mlx, a new Max-like bHLHZip family member: the center stage of a novel transcription factors regulatory pathway?". Oncogene. 19 (29): 3266–77. doi:10.1038/sj.onc.1203634. PMID 10918583. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.