DNA replication licensing factor MCM5 is a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, res ...
that in humans is encoded by the ''MCM5''
gene
In biology, the word gene (from , ; "... Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a b ...
.
Function
The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation.
See also
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Mini Chromosome Maintenance
Interactions
MCM5 has been shown to
interact with:
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Cell division cycle 7-related protein kinase,
[
* ]MCM2
DNA replication licensing factor MCM2 is a protein that in humans is encoded by the ''MCM2'' gene.
Function
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the ini ...
,[
* ]MCM3
DNA replication licensing factor MCM3 is a protein that in humans is encoded by the ''MCM3'' gene.
Function
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the init ...
,[
* ]MCM7
DNA replication licensing factor MCM7 is a protein that in humans is encoded by the ''MCM7'' gene.
Function
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the in ...
,ORC2L
Origin recognition complex subunit 2 is a protein that is encoded by the ORC2 (ORC2L) gene in humans.
Function
The origin recognition complex (ORC) is a highly conserved six subunits protein complex essential for the initiation of the DNA rep ...
,ORC6L
Origin recognition complex subunit 6 is a protein that in humans is encoded by the ORC6 (ORC6L) gene.
Background
The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA repl ...
,[ and
* ]STAT1
Signal transducer and activator of transcription 1 (STAT1) is a transcription factor which in humans is encoded by the ''STAT1'' gene. It is a member of the STAT protein family.
Function
All STAT molecules are phosphorylated by receptor associ ...
.
References
Further reading
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