MCM3
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DNA replication licensing factor MCM3 is a
protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that in humans is encoded by the ''MCM3''
gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.


Function

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the
pre-replication complex A pre-replication complex (pre-RC) is a protein complex that forms at the origin of replication during the initiation step of DNA replication. Formation of the pre-RC is required for DNA replication to occur. Complete and faithful replication of ...
(pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein is a subunit of the protein complex that consists of MCM2-7. It has been shown to interact directly with MCM5/CDC46. This protein also interacts with, and thus is acetylated by MCM3AP, a chromatin-associated acetyltransferase. The acetylation of this protein inhibits the initiation of DNA replication and cell cycle progression.


Interactions

MCM3 has been shown to
interact Advocates for Informed Choice, dba interACT or interACT Advocates for Intersex Youth, is a 501(c)(3) nonprofit organization using innovative strategies to advocate for the legal and human rights of children with intersex traits. The organizati ...
with: * CDC45-related protein, *
CDC6 Cell division control protein 6 homolog is a protein that in humans is encoded by the ''CDC6'' gene. The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc6, a protein essential for the initiation of DNA replication. ...
, *
DBF4 Protein DBF4 homolog A is a protein that is encoded by the ''DBF4'' gene in humans. Interactions DBF4 has been shown to interact with: * Cell division cycle 7-related protein kinase, * MCM3, * MCM7, * ORC2L, and * ORC6L Origin recogni ...
, *
MCM2 DNA replication licensing factor MCM2 is a protein that in humans is encoded by the ''MCM2'' gene. Function The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the ini ...
*
MCM3AP 80 kDa MCM3-associated protein is a protein that in humans is encoded by the ''MCM3AP'' gene. Function The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein enco ...
, *
MCM5 DNA replication licensing factor MCM5 is a protein that in humans is encoded by the ''MCM5'' gene. Function The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiat ...
, *
MCM7 DNA replication licensing factor MCM7 is a protein that in humans is encoded by the ''MCM7'' gene. Function The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the in ...
, *
ORC4L Origin recognition complex subunit 4 is a protein that in humans is encoded by the ORC4 (ORC4L) gene. Function The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replic ...
, and *
ORC5L Origin recognition complex subunit 5 is a protein that in humans is encoded by the ORC5 (ORC5L) gene. Function The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replic ...
.


See also

*
Mini Chromosome Maintenance The minichromosome maintenance protein complex (MCM) is a DNA helicase essential for genomic DNA replication. Eukaryotic MCM consists of six gene products, Mcm2–7, which form a heterohexamer. As a critical protein for cell division, MCM is also t ...


References


Further reading

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