Alexander Robertus Todd, Baron Todd (2 October 1907 – 10 January 1997) was a British

biochemist Biochemists are scientists who are trained in biochemistry. They study chemical processes and chemical transformations in living organisms. Biochemists study DNA, proteins and cell parts. The word "biochemist" is a portmanteau of "biological ch ...

whose research on the structure and

synthesis Synthesis or synthesize may refer to: Science Chemistry and biochemistry * Chemical synthesis, the execution of chemical reactions to form a more complex molecule from chemical precursors **Organic synthesis, the chemical synthesis of organ ...

nucleotide Nucleotides are organic molecules consisting of a nucleoside and a phosphate. They serve as monomeric units of the nucleic acid polymers – deoxyribonucleic acid (DNA) and ribonucleic acid (RNA), both of which are essential biomolecu ...

nucleoside Nucleosides are glycosylamines that can be thought of as nucleotides without a phosphate group. A nucleoside consists simply of a nucleobase (also termed a nitrogenous base) and a five-carbon sugar (ribose or 2'-deoxyribose) whereas a nucleoti ...

s, and nucleotide

coenzyme A cofactor is a non- protein chemical compound or metallic ion that is required for an enzyme's role as a catalyst (a catalyst is a substance that increases the rate of a chemical reaction). Cofactors can be considered "helper molecules" that as ...

s gained him the

Nobel Prize for Chemistry ) , image = Nobel Prize.png , alt = A golden medallion with an embossed image of a bearded man facing left in profile. To the left of the man is the text "ALFR•" then "NOBEL", and on the right, the text (smaller) "NAT•" then "M ...

in 1957.

Early life and education

Todd was born in Cathcart in outer

Glasgow Glasgow ( ; sco, Glesca or ; gd, Glaschu ) is the most populous city in Scotland and the fourth-most populous city in the United Kingdom, as well as being the 27th largest city by population in Europe. In 2020, it had an estimated popu ...

, the son of Alexander Todd, a clerk with the Glasgow Subway, and his wife, Jane Lowry. He attended Allan Glen's School and graduated from the

University of Glasgow , image = UofG Coat of Arms.png , image_size = 150px , caption = Coat of arms Flag , latin_name = Universitas Glasguensis , motto = la, Via, Veritas, Vita , ...

with a BSc in 1928. He received a PhD (Dr.phil.nat.) from

Johann Wolfgang Goethe University of Frankfurt am Main Goethe University (german: link=no, Johann Wolfgang Goethe-Universität Frankfurt am Main) is a university located in Frankfurt am Main, Germany. It was founded in 1914 as a citizens' university, which means it was founded and funded by the weal ...

in 1931 for his thesis on the chemistry of the

bile Bile (from Latin ''bilis''), or gall, is a dark-green-to-yellowish-brown fluid produced by the liver of most vertebrates that aids the digestion of lipids in the small intestine. In humans, bile is produced continuously by the liver (liver bi ...

acids. Todd was awarded an

1851 Research Fellowship The 1851 Research Fellowship is a scheme conducted by the Royal Commission for the Exhibition of 1851 to annually award a three-year research scholarship to approximately eight "young scientists or engineers of exceptional promise". The fellowship ...

from the

Royal Commission for the Exhibition of 1851 The Royal Commission for the Exhibition of 1851 is an institution founded in 1850 to administer the international exhibition of 1851, officially called the Great Exhibition of the Works of Industry of all Nations. The Great Exhibition was held ...

, and, after studying at

Oriel College, Oxford Oriel College () is a constituent college of the University of Oxford in Oxford, England. Located in Oriel Square, the college has the distinction of being the oldest royal foundation in Oxford (a title formerly claimed by University College, ...

, he gained another doctorate in 1933.

Career

Todd held posts with the Lister Institute, the

University of Edinburgh The University of Edinburgh ( sco, University o Edinburgh, gd, Oilthigh Dhùn Èideann; abbreviated as ''Edin.'' in post-nominals) is a public research university based in Edinburgh, Scotland. Granted a royal charter by King James VI in 1 ...

(staff, 1934–1936) and the

University of London The University of London (UoL; abbreviated as Lond or more rarely Londin in post-nominals) is a federal public research university located in London, England, United Kingdom. The university was established by royal charter in 1836 as a degr ...

, where he was appointed

Reader A reader is a person who reads. It may also refer to: Computing and technology * Adobe Reader (now Adobe Acrobat), a PDF reader * Bible Reader for Palm, a discontinued PDA application * A card reader, for extracting data from various forms of ...

Biochemistry Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology and ...

. In 1938, Alexander Todd spent six months as a visiting professor at

California Institute of Technology The California Institute of Technology (branded as Caltech or CIT)The university itself only spells its short form as "Caltech"; the institution considers other spellings such a"Cal Tech" and "CalTech" incorrect. The institute is also occasional ...

, eventually declining an offer of faculty position. Todd became the

Sir Samuel Hall Chair of Chemistry The Sir Samuel Hall Chair of Chemistry is the named Chair of Chemistry in the School of Chemistry at the University of Manchester, established through an endowment of £36,000 in 1913 by the Hall family.Portrait of a University, 1851-1951: To Co ...

and Director of the Chemical Laboratories of the

University of Manchester The University of Manchester is a public university, public research university in Manchester, England. The main campus is south of Manchester city centre, Manchester City Centre on Wilmslow Road, Oxford Road. The university owns and operates majo ...

in 1938, where he began working on nucleosides, compounds that form the structural units of nucleic acids ( DNA and RNA). In 1944, he was appointed to the 1702 Chair of Chemistry in the

University of Cambridge , mottoeng = Literal: From here, light and sacred draughts. Non literal: From this place, we gain enlightenment and precious knowledge. , established = , other_name = The Chancellor, Masters and Schola ...

, which he held until his retirement in 1971. In 1949, he synthesised

adenosine triphosphate Adenosine triphosphate (ATP) is an organic compound that provides energy to drive many processes in living cells, such as muscle contraction, nerve impulse propagation, condensate dissolution, and chemical synthesis. Found in all known forms ...

(ATP) and

flavin adenine dinucleotide Flavin may refer to: Placename * Flavin, Aveyron, a commune in southern France Surname * Adrian Flavin (born 1979), a professional rugby player * Christopher Flavin, president of the Worldwatch Institute * Dan Flavin (1933–1996), a minimalis ...

(FAD). Todd served as a visiting professor at the

University of Chicago The University of Chicago (UChicago, Chicago, U of C, or UChi) is a private research university in Chicago, Illinois. Its main campus is located in Chicago's Hyde Park neighborhood. The University of Chicago is consistently ranked among the b ...

in Autumn 1948 and

University of Sydney The University of Sydney (USYD), also known as Sydney University, or informally Sydney Uni, is a public research university located in Sydney, Australia. Founded in 1850, it is the oldest university in Australia and is one of the country's si ...

in 1950. In 1955, he helped elucidate the structure of vitamin B₁₂, although the final formula and definite structure was determined by

Dorothy Hodgkin Dorothy Mary Crowfoot Hodgkin (née Crowfoot; 12 May 1910 – 29 July 1994) was a Nobel Prize-winning British chemist who advanced the technique of X-ray crystallography to determine the structure of biomolecules, which became essential fo ...

and her team, and later worked on the structure and synthesis of vitamin B₁ and

vitamin E Vitamin E is a group of eight fat soluble compounds that include four tocopherols and four tocotrienols. Vitamin E deficiency, which is rare and usually due to an underlying problem with digesting dietary fat rather than from a diet low in vi ...

, the anthocyanins (the pigments of flowers and fruits) from insects (aphids, beetles) and studied

alkaloids Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of similar ...

found in

hashish Hashish ( ar, حشيش, ()), also known as hash, "dry herb, hay" is a drug made by compressing and processing parts of the cannabis plant, typically focusing on flowering buds (female flowers) containing the most trichomes. European Monitoring ...

and

marijuana Cannabis, also known as marijuana among other names, is a psychoactive drug from the cannabis plant. Native to Central or South Asia, the cannabis plant has been used as a drug for both recreational and entheogenic purposes and in various t ...

. He served as chairman of the

Government of the United Kingdom ga, Rialtas a Shoilse gd, Riaghaltas a Mhòrachd , image = HM Government logo.svg , image_size = 220px , image2 = Royal Coat of Arms of the United Kingdom (HM Government).svg , image_size2 = 180px , caption = Royal Arms , date_est ...

's advisory committee on scientific policy from 1952 to 1964. He was elected a

Fellow A fellow is a concept whose exact meaning depends on context. In learned or professional societies, it refers to a privileged member who is specially elected in recognition of their work and achievements. Within the context of higher education ...

Christ's College, Cambridge Christ's College is a constituent college of the University of Cambridge. The college includes the Master, the Fellows of the College, and about 450 undergraduate and 170 graduate students. The college was founded by William Byngham in 1437 as ...

in 1944 and was

Master Master or masters may refer to: Ranks or titles * Ascended master, a term used in the Theosophical religious tradition to refer to spiritually enlightened beings who in past incarnations were ordinary humans *Grandmaster (chess), National Master ...

from 1963 to 1978. He became

Chancellor Chancellor ( la, cancellarius) is a title of various official positions in the governments of many nations. The original chancellors were the of Roman courts of justice—ushers, who sat at the or lattice work screens of a basilica or law cou ...

of the

University of Strathclyde The University of Strathclyde ( gd, Oilthigh Shrath Chluaidh) is a public research university located in Glasgow, Scotland. Founded in 1796 as the Andersonian Institute, it is Glasgow's second-oldest university, having received its royal chart ...

in 1975, and a visiting professor at

Hatfield Polytechnic The University of Hertfordshire (UH) is a public university in Hertfordshire, United Kingdom. The university is based largely in Hatfield, Hertfordshire. Its antecedent institution, Hatfield Technical College, was founded in 1948 and was ident ...

(1978–1986). Among his many honours, including over 40 honorary degrees, he was elected as a

Fellow of the Royal Society Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the judges of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural knowledge, including mathemati ...

in 1942, a member of the United States

National Academy of Sciences The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nat ...

in 1955, a member of the

American Academy of Arts and Sciences The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, a ...

in 1957, and the

American Philosophical Society The American Philosophical Society (APS), founded in 1743 in Philadelphia, is a scholarly organization that promotes knowledge in the sciences and humanities through research, professional meetings, publications, library resources, and communit ...

in 1965. He was

President of the Royal Society The president of the Royal Society (PRS) is the elected Head of the Royal Society of London who presides over meetings of the society's council. After informal meetings at Gresham College, the Royal Society was officially founded on 28 November ...

from 1975 to 1980 and became a member of the

Order of Merit The Order of Merit (french: link=no, Ordre du Mérite) is an order of merit for the Commonwealth realms, recognising distinguished service in the armed forces, science, art, literature, or for the promotion of culture. Established in 1902 by ...

in 1977. In 1981, Todd became a founding member of the

World Cultural Council The World Cultural Council is an international organization whose goals are to promote cultural values, goodwill and philanthropy among individuals. The organization founded in 1981 and based in Mexico, has held a yearly award ceremony since 198 ...

Personal life and death

In 1937, Todd married Alison Sarah Dale (d.1987), daughter of Nobel Prize winner Sir Henry Dale, who, as Todd did, served as President of the

Royal Society of London The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, r ...

. They had a son, Alexander Henry, and two daughters, Helen Jean and Hilary Alison. Todd died in Cambridge on 10 January 1997 at the age of 89 following a heart attack.

Honours

Todd was honoured as a Nieuwland Lecturer at the

University of Notre Dame The University of Notre Dame du Lac, known simply as Notre Dame ( ) or ND, is a private Catholic research university in Notre Dame, Indiana, outside the city of South Bend. French priest Edward Sorin founded the school in 1842. The main c ...

in 1948, an Arthur D. Little Visiting Professor at

Massachusetts Institute of Technology The Massachusetts Institute of Technology (MIT) is a private land-grant research university in Cambridge, Massachusetts. Established in 1861, MIT has played a key role in the development of modern technology and science, and is one of th ...

in 1954, and a Hitchcock Lecturer at

University of California, Berkeley The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California) is a public land-grant research university in Berkeley, California. Established in 1868 as the University of California, it is the state's first land-grant un ...

, in 1957. He was

knighted A knight is a person granted an honorary title of knighthood by a head of state (including the Pope) or representative for service to the monarch, the church or the country, especially in a military capacity. Knighthood finds origins in the G ...

as Sir Alexander Todd in 1954 and was created a

Life Peer In the United Kingdom, life peers are appointed members of the peerage whose titles cannot be inherited, in contrast to hereditary peers. In modern times, life peerages, always created at the rank of baron, are created under the Life Peerages ...

as Baron Todd of Trumpington in the County of Cambridge on 16 April 1962. He is commemorated by a

blue plaque A blue plaque is a permanent sign installed in a public place in the United Kingdom and elsewhere to commemorate a link between that location and a famous person, event, or former building on the site, serving as a historical marker. The term ...

erected by the

Royal Society of Chemistry The Royal Society of Chemistry (RSC) is a learned society (professional association) in the United Kingdom with the goal of "advancing the chemical sciences". It was formed in 1980 from the amalgamation of the Chemical Society, the Royal Inst ...

at the Department of Chemistry in the University of Cambridge.

Bibliography

Notes

References

* : "The Era of Todd, Plumb and Snow", by Sir

David Cannadine Sir David Nicholas Cannadine (born 7 September 1950) is a British author and historian who specialises in modern history, Britain and the history of business and philanthropy. He is currently the Dodge Professor of History at Princeton Un ...

.
Obituary
in

the Independent ''The Independent'' is a British online newspaper. It was established in 1986 as a national morning printed paper. Nicknamed the ''Indy'', it began as a broadsheet and changed to tabloid format in 2003. The last printed edition was publish ...

Obituary
in ''

The New York Times ''The New York Times'' (''the Times'', ''NYT'', or the Gray Lady) is a daily newspaper based in New York City with a worldwide readership reported in 2020 to comprise a declining 840,000 paid print subscribers, and a growing 6 million paid ...

External links

* including the Nobel Lecture, 11 December 1957 ''Synthesis in the Study of Nucleotides'' * *. Video of an interviewed with Lewis Wolpert. Duration 37 minutes.
The Papers of Lord Todd
held at

Churchill Archives Centre The Churchill Archives Centre (CAC) at Churchill College at the University of Cambridge is one of the largest repositories in the United Kingdom for the preservation and study of modern personal papers. It is best known for housing the papers of ...

{{DEFAULTSORT:Todd, Alexander R. 1907 births 1997 deaths Academics of the University of Edinburgh Academics of the University of Hertfordshire Academics of the University of London Academics of the Victoria University of Manchester Alumni of Oriel College, Oxford Alumni of the University of Glasgow British Nobel laureates Fellows of the Royal Society of Edinburgh Fellows of the Royal Society Foreign associates of the National Academy of Sciences Foreign Members of the Russian Academy of Sciences Foreign Members of the USSR Academy of Sciences Founding members of the World Cultural Council Knights Bachelor Life peers Masters of Christ's College, Cambridge Members of the Austrian Academy of Sciences Members of the Order of Merit Nobel laureates in Chemistry People associated with the University of Strathclyde People educated at Allan Glen's School Scientists from Glasgow Presidents of the British Science Association Presidents of the Royal Society Recipients of the Copley Medal Recipients of the Pour le Mérite (civil class) Royal Medal winners Scottish biochemists Scottish biologists Scottish chemists Scottish Nobel laureates Professors of chemistry (Cambridge, 1702) Goethe University Frankfurt alumni People from Oakington People from Trumpington 20th-century biologists Vitamin researchers Life peers created by Elizabeth II Members of the American Philosophical Society