The peyote (; ''Lophophora williamsii'' ) is a small, spineless

cactus A cactus (, or less commonly, cactus) is a member of the plant family Cactaceae, a family comprising about 127 genera with some 1750 known species of the order Caryophyllales. The word ''cactus'' derives, through Latin, from the Ancient Gree ...

which contains psychoactive alkaloids, particularly mescaline. ''Peyote'' is a Spanish word derived from the Nahuatl (), meaning "caterpillar cocoon", from a root , "to glisten". p. 246. See

peyotl The peyote (; ''Lophophora williamsii'' ) is a small, spineless cactus which contains Psychoactive cactus, psychoactive alkaloids, particularly mescaline. ''Peyote'' is a Spanish word derived from the Nahuatl (), meaning "caterpillar Pupa#Cocoo ...

in Wiktionary. Peyote is native to

Mexico Mexico (Spanish: México), officially the United Mexican States, is a country in the southern portion of North America. It is bordered to the north by the United States; to the south and west by the Pacific Ocean; to the southeast by Guatema ...

and southwestern

Texas Texas (, ; Spanish: ''Texas'', ''Tejas'') is a state in the South Central region of the United States. At 268,596 square miles (695,662 km2), and with more than 29.1 million residents in 2020, it is the second-largest U.S. state by ...

. It is found primarily in the

Sierra Madre Occidental The Sierra Madre Occidental is a major mountain range system of the North American Cordillera, that runs northwest–southeast through northwestern and western Mexico, and along the Gulf of California. The Sierra Madre is part of the American ...

, the

Chihuahuan Desert The Chihuahuan Desert ( es, Desierto de Chihuahua, ) is a desert ecoregion designation covering parts of northern Mexico and the southwestern United States. It occupies much of far West Texas, the middle to lower Rio Grande Valley and the lo ...

and in the states of

Nayarit Nayarit (), officially the Free and Sovereign State of Nayarit ( es, Estado Libre y Soberano de Nayarit), is one of the 31 states that, along with Mexico City, comprise the Federal Entities of Mexico. It is divided in 20 municipalities and its ...

, Coahuila, Nuevo León,

Tamaulipas Tamaulipas (), officially the Free and Sovereign State of Tamaulipas ( es, Estado Libre y Soberano de Tamaulipas), is a state in the northeast region of Mexico; one of the 31 states which, along with Mexico City, comprise the 32 Federal Entiti ...

, and San Luis Potosí among scrub. It flowers from March to May, and sometimes as late as September. The flowers are pink, with thigmotactic anthers (like '' Opuntia''). Known for its psychoactive properties when ingested, peyote has at least 5,500 years of

entheogen Entheogens are psychoactive substances that induce alterations in perception, mood, consciousness, cognition, or behavior for the purposes of engendering spiritual development or otherwiseRätsch, Christian, ''The Encyclopedia of Psychoac ...

ic and

medicinal Medicine is the science and practice of caring for a patient, managing the diagnosis, prognosis, prevention, treatment, palliation of their injury or disease, and promoting their health. Medicine encompasses a variety of health care practic ...

use by indigenous North Americans.

Description

The various species of the genus ''

Lophophora ''Lophophora'' () is a genus of spineless, button-like cacti. Its area range covers southern through northeastern and north-central Mexico to Querétaro in central Mexico. The species are extremely slow growing, sometimes taking up to thirty ye ...

'' grow low to the ground and they often form groups with numerous, crowded shoots. The blue-green, yellow-green or sometimes reddish-green shoots are mostly flattened spheres with sunken shoot tips. They can reach heights of and diameters of . There are often significant, vertical ribs consisting of low and rounded or hump-like bumps. From the cusp

areole In botany, areoles are small light- to dark-colored bumps on cacti out of which grow clusters of spines. Areoles are important diagnostic features of cacti, and identify them as a family distinct from other succulent plants. Gordon Rowley - W ...

s arises a tuft of soft, yellowish or whitish woolly hairs. Spines are absent. Flowers are pink or white to slightly yellowish, sometimes reddish. They open during the day, are from long, and reach a diameter from .

The cactus produces flowers sporadically; these are followed by small edible pink fruit. The club-shaped to elongated, fleshy fruits are bare and more or less rosy colored. At maturity, they are brownish-white and dry. The fruits do not burst open on their own and they are between long. They contain black, pear-shaped seeds that are 1 to 1.5 mm long and 1 mm wide. The seeds require hot and humid conditions to germinate. Peyote contains a large spectrum of phenethylamine alkaloids. The principal one is mescaline for which the content of ''Lophophora williamsii'' is about 0.4% fresh (undried) and 3–6% dried.

Taxonomy

French botanist

Charles Antoine Lemaire Charles Antoine Lemaire (1 November 1800, in Paris – 22 June 1871, in Paris), was a French botanist and botanical author, noted for his publications on Cactaceae. Education Born the son of Antoine Charles Lemaire and Marie Jeanne Davio, he ha ...

described the species as ''Echinocactus williamsii'' in 1845. It was placed in the new genus ''Lophophora'' in 1894 by American botanist John Merle Coulter.

Distribution and habitat

''L. williamsii'' is native to southern North America, mainly distributed in

. In the United States, it grows in Southern

. In Mexico, it grows in the states of Chihuahua, Coahuila, Nuevo León, and

in the north to San Luis Potosi and

Zacatecas , image_map = Zacatecas in Mexico (location map scheme).svg , map_caption = State of Zacatecas within Mexico , coordinates = , coor_pinpoint = , coordinates_footnotes = , subdivision_type ...

. It is primarily found at elevations of and exceptionally up to in the

Chihuahuan desert The Chihuahuan Desert ( es, Desierto de Chihuahua, ) is a desert ecoregion designation covering parts of northern Mexico and the southwestern United States. It occupies much of far West Texas, the middle to lower Rio Grande Valley and the lo ...

, but is also present in the more mild climate of Tamaulipas. Its habitat is primarily in desert scrub, particularly thorn scrub in Tamaulipas. It is common on or near

limestone Limestone ( calcium carbonate ) is a type of carbonate sedimentary rock which is the main source of the material lime. It is composed mostly of the minerals calcite and aragonite, which are different crystal forms of . Limestone forms whe ...

hills.

Cultivation

Peyote is extremely slow growing. Cultivated specimens grow considerably faster, sometimes taking less than three years to go from seedling to mature flowering adult. More rapid growth can be achieved by grafting peyote onto mature San Pedro root stock. The top of the above-ground part of the cactus, the crown, consists of disc-shaped buttons. These are cut above the roots and sometimes dried. When done properly, the top of the root forms a callus and the root does not rot. When poor harvesting techniques are used, however, the entire plant dies. Currently in South Texas, peyote grows naturally but has been over-harvested, to the point that the state has listed it as an endangered species. Cultivation is an important conservation tool for this particular species.

Uses

Psychoactive and medicinal

When used for its psychoactive properties, common doses for pure mescaline range from roughly 200 to 400 mg. This translates to a dose of roughly 10 to 20 g of dried peyote buttons of average potency; however, potency varies considerably between samples, making it difficult to measure doses accurately without first extracting the mescaline. The effects last about 10 to 12 hours. Peyote is reported to trigger rich visual or auditory effects (see synesthesia) and spiritual or philosophical insights. In addition to psychoactive use, some Native American tribes use the plant in the belief it may have curative properties. They employ peyote for such varied ailments as toothache, pain in childbirth,

fever Fever, also referred to as pyrexia, is defined as having a temperature above the normal range due to an increase in the body's temperature set point. There is not a single agreed-upon upper limit for normal temperature with sources using val ...

, breast pain, skin diseases, rheumatism,

diabetes Diabetes, also known as diabetes mellitus, is a group of metabolic disorders characterized by a high blood sugar level ( hyperglycemia) over a prolonged period of time. Symptoms often include frequent urination, increased thirst and increased ...

, colds, and blindness. Although uncommon, use of peyote and mescaline has been associated with clinically significant effects requiring treatment. The US Dispensary lists peyote under the name ''

Anhalonium ''Ariocarpus'' is a small genus of succulent, subtropical plants of the family Cactaceae. The name comes from the ancient Greek "aria" (an oak type) and "carpos" (=fruit) because of the resemblance of the fruit of the two genus in acorn form. A ...

'', and states it can be used in various preparations for

neurasthenia Neurasthenia (from the Ancient Greek νεῦρον ''neuron'' "nerve" and ἀσθενής ''asthenés'' "weak") is a term that was first used at least as early as 1829 for a mechanical weakness of the nerves and became a major diagnosis in North A ...

, hysteria, and

asthma Asthma is a long-term inflammatory disease of the airways of the lungs. It is characterized by variable and recurring symptoms, reversible airflow obstruction, and easily triggered bronchospasms. Symptoms include episodes of wheezing, co ...

Peyote also contains the alkaloid called

hordenine Hordenine is an alkaloid of the phenethylamine class that occurs naturally in a variety of plants, taking its name from one of the most common, barley (''Hordeum'' species). Chemically, hordenine is the ''N''-methyl derivative of ''N''-methyltyra ...

(also called peyocactin).

History

In 2005, researchers used radiocarbon dating and alkaloid analysis to study two specimens of peyote buttons found in archaeological digs from a site called Shumla Cave No. 5 on the Rio Grande in

. The results dated the specimens to between 3780 and 3660

BCE Common Era (CE) and Before the Common Era (BCE) are year notations for the Gregorian calendar (and its predecessor, the Julian calendar), the world's most widely used calendar era. Common Era and Before the Common Era are alternatives to the or ...

. Alkaloid extraction yielded approximately 2% of the alkaloids including mescaline in both samples. This indicates that native North Americans were likely to have used peyote since at least five-and-a-half thousand years ago. Specimens from a burial cave in west central Coahuila, Mexico have been similarly analyzed and dated to 810 to 1070 CE. Lophophorawilliamsii

From earliest recorded time, peyote has been used by indigenous peoples, such as the

Huichol The Huichol or Wixárika are an indigenous people of Mexico and the United States living in the Sierra Madre Occidental range in the states of Nayarit, Jalisco, Zacatecas, and Durango, as well as in the United States in the states of California ...

of northern Mexico and by various Native American tribes, native to or relocated to the Southern Plains states of present-day Oklahoma and Texas. Its usage was also recorded among various Southwestern Athabaskan-language tribal groups. The

Tonkawa The Tonkawa are a Native American tribe indigenous to present-day Oklahoma. Their Tonkawa language, now extinct, is a linguistic isolate. Today, Tonkawa people are enrolled in the federally recognized Tonkawa Tribe of Indians of Oklahoma. ...

, the

Mescalero Mescalero or Mescalero Apache ( apm, Naa'dahéńdé) is an Apache tribe of Southern Athabaskan–speaking Native Americans. The tribe is federally recognized as the Mescalero Apache Tribe of the Mescalero Apache Reservation, located in south-cen ...

, and

Lipan Apache Lipan Apache are a band of Apache, a Southern Athabaskan Indigenous people, who have lived in the Southwest and Southern Plains for centuries. At the time of European and African contact, they lived in New Mexico, Colorado, Oklahoma, Texas, and ...

were the source or first practitioners of

peyote religion The Native American Church (NAC), also known as Peyotism and Peyote Religion, is a Native American religion that teaches a combination of traditional Native Americans in the United States, Native American beliefs and Christianity, with sacrament ...

in the regions north of present-day Mexico. They were also the principal group to introduce peyote to newly arrived migrants, such as the Comanche and

Kiowa Kiowa () people are a Native American tribe and an indigenous people of the Great Plains of the United States. They migrated southward from western Montana into the Rocky Mountains in Colorado in the 17th and 18th centuries,Pritzker 326 and e ...

from the Northern Plains. The religious, ceremonial, and healing uses of peyote may date back over 2,000 years. Under the auspices of what came to be known as the

Native American Church The Native American Church (NAC), also known as Peyotism and Peyote Religion, is a Native American religion that teaches a combination of traditional Native American beliefs and Christianity, with sacramental use of the entheogen peyote. The ...

, in the 19th century, American Indians in more widespread regions to the north began to use peyote in religious practices, as part of a revival of native spirituality. Its members refer to peyote as "the sacred medicine", and use it to combat spiritual, physical, and other social ills. Concerned about the drug's psychoactive effects, between the 1880s and 1930s, U.S. authorities attempted to ban Native American religious rituals involving peyote, including the Ghost Dance. Today the Native American Church is one among several religious organizations to use peyote as part of its religious practice. Some users claim the drug connects them to God. Traditional Navajo belief or ceremonial practice did not mention the use of peyote before its introduction by the neighboring Utes. The Navajo Nation now has the most members of the Native American Church. John Raleigh Briggs (1851–1907) was the first to draw scientific attention of the Western scientific world to peyote. Louis Lewin described ''Anhalonium lewinii'' in 1888.

Arthur Heffter Arthur Carl Wilhelm Heffter (15 June 1859, in Leipzig – 8 February 1925, in Berlin) was a German pharmacologist and chemist. He was the first chairman of the German Society of Pharmacologists, and was largely responsible for the first ''Handbo ...

conducted self experiments on its effects in 1897. Similarly,

Norwegian Norwegian, Norwayan, or Norsk may refer to: *Something of, from, or related to Norway, a country in northwestern Europe * Norwegians, both a nation and an ethnic group native to Norway * Demographics of Norway *The Norwegian language, including ...

ethnographer Ethnography (from Greek ''ethnos'' "folk, people, nation" and ''grapho'' "I write") is a branch of anthropology and the systematic study of individual cultures. Ethnography explores cultural phenomena from the point of view of the subject o ...

Carl Sofus Lumholtz studied and wrote about the use of peyote among the Indians of Mexico. Lumholtz also reported that, lacking other intoxicants, Texas Rangers captured by Union forces during the

American Civil War The American Civil War (April 12, 1861 – May 26, 1865; also known by other names) was a civil war in the United States. It was fought between the Union ("the North") and the Confederacy ("the South"), the latter formed by states ...

soaked peyote buttons in water and became "intoxicated with the liquid".

Adverse reactions

A study published in 2007 found no evidence of long-term cognitive problems related to peyote use in

ceremonies, but researchers stressed their results may not apply to those who use peyote in other contexts. A four-year large-scale study of Navajo who regularly ingested peyote found only one case where peyote was associated with a

psychotic break Psychosis is a condition of the mind that results in difficulties determining what is real and what is not real. Symptoms may include delusions and hallucinations, among other features. Additional symptoms are incoherent speech and behavior t ...

in an otherwise healthy person; other psychotic episodes were attributed to peyote use in conjunction with pre-existing substance abuse or mental health problems. Later research found that those with pre-existing mental health issues are more likely to have adverse reactions to peyote. Peyote use does not appear to be associated with

hallucinogen persisting perception disorder Hallucinogen persisting perception disorder (HPPD) is a non-psychotic disorder in which a person experiences apparent lasting or persistent visual hallucinations or perceptual distortions after a previous use of drugs, including but not limited t ...

(a.k.a. "flashbacks") after religious use. Peyote also does not seem to be associated with

physical dependence Physical dependence is a physical condition caused by chronic use of a tolerance-forming drug, in which abrupt or gradual drug withdrawal causes unpleasant physical symptoms. Physical dependence can develop from low-dose therapeutic use of certai ...

, but some users may experience

psychological dependence Psychological dependence is a cognitive disorder that involves emotional–motivational withdrawal symptoms—e.g. anxiety and anhedonia—upon cessation of prolonged drug abuse or certain repetitive behaviors. It develops through frequent exp ...

. Peyote can have strong

emetic Vomiting (also known as emesis and throwing up) is the involuntary, forceful expulsion of the contents of one's stomach through the mouth and sometimes the nose. Vomiting can be the result of ailments like food poisoning, gastroenteritis ...

effects, and one death has been attributed to esophageal bleeding caused by vomiting after peyote ingestion in a Native American patient with a history of alcohol abuse. Peyote is also known to cause potentially serious variations in heart rate, blood pressure, breathing, and

pupillary dilation Pupillary response is a physiological response that varies the size of the pupil, via the optic and oculomotor cranial nerve. A constriction response ( miosis), is the narrowing of the pupil, which may be caused by scleral buckles or drugs such ...

. Research into the

huichol The Huichol or Wixárika are an indigenous people of Mexico and the United States living in the Sierra Madre Occidental range in the states of Nayarit, Jalisco, Zacatecas, and Durango, as well as in the United States in the states of California ...

natives of central-western Mexico, who have taken peyote regularly for an estimated 1,500 years or more, found no evidence of

chromosome A chromosome is a long DNA molecule with part or all of the genetic material of an organism. In most chromosomes the very long thin DNA fibers are coated with packaging proteins; in eukaryotic cells the most important of these proteins are ...

damage in either men or women.

Cultural significance

Wixarika (Huichol) culture

The Wixarika religion consists of four principal deities: Corn, Kayumarie (Blue Deer), Hikuri (Peyote), and the Eagle, all descended from their Sun God. Schaefer has interpreted this to mean that peyote is the soul of their religious culture and a visionary sacrament that opens a pathway to the other deities. File:Arte Huichol A.JPG File:MaskNecklacesTep.JPG File:Huichol-Fadenbild.jpg File:Huichol Trabajando.JPG

Legality

United Nations

Canada

Mescaline is listed as a Schedule III controlled substance under the Canadian

Controlled Drugs and Substances Act The ''Controlled Drugs and Substances Act'' (french: Loi réglementant certaines drogues et autres substances) (the ''Act'') is Canada's federal drug control statute. Passed in 1996 under Prime Minister Jean Chrétien's government, it repeal ...

, but peyote is specifically exempt. Possession and use of peyote plants is legal.

United States

Non-drug uses of peyote in religious ceremonies by the Native American Church and its members is exempt from registration. This law has been codified as a statute in the

American Indian Religious Freedom Act The American Indian Religious Freedom Act, Public Law No. 95–341, 92 Stat. 469 (Aug. 11, 1978) (commonly abbreviated to AIRFA), codified at , is a United States federal law, enacted by joint resolution of the Congress in 1978. Prior to the ac ...

of 1978, and made part of the

common law In law, common law (also known as judicial precedent, judge-made law, or case law) is the body of law created by judges and similar quasi-judicial tribunals by virtue of being stated in written opinions."The common law is not a brooding omnipres ...

in '' Peyote Way Church of God, Inc. v. Thornburgh'', (5th Cir. 1991); it is also in

administrative law Administrative law is the division of law that governs the activities of executive branch agencies of government. Administrative law concerns executive branch rule making (executive branch rules are generally referred to as "regulations"), ad ...

at the which states for "Special Exempt Persons":

Section 1307.31 Native American Church. The listing of peyote as a controlled substance in Schedule I does not apply to the nondrug use of peyote in bona fide religious ceremonies of the Native American Church, and members of the Native American Church so using peyote are exempt from registration. Any person who manufactures peyote for or distributes peyote to the Native American Church, however, is required to obtain registration annually and to comply with all other requirements of law.

''U.S. v. Boyll'', 774 F.Supp. 1333 (D.N.M. 1991) addresses this racial issue specifically and concludes:

For the reasons set out in this Memorandum Opinion and Order, the Court holds that, pursuant to 21 C.F.R. § 1307.31 (1990), the classification of peyote as a Schedule I controlled substance, see 21 U.S.C. § 812(c), Schedule I(c)(12), does not apply to the importation, possession or use of peyote for 'bona fide' ceremonial use by members of the Native American Church, regardless of race.

Following the passage of the

Amendments of 1994, United States

federal law Federal law is the body of law created by the federal government of a country. A federal government is formed when a group of political units, such as states or provinces join in a federation, delegating their individual sovereignty and many po ...

(and many state laws) protects the harvest, possession,

consumption Consumption may refer to: *Resource consumption *Tuberculosis, an infectious disease, historically * Consumption (ecology), receipt of energy by consuming other organisms * Consumption (economics), the purchasing of newly produced goods for curren ...

and cultivation of peyote as part of " bona fide religious ceremonies" (the federal statute is the American Indian Religious Freedom Act, codified at , "Traditional Indian religious use of the peyote sacrament", exempting only use by Native American persons. US v. Boyll expanded permitted use to all persons engaged in traditional Indian religious use, regardless of race. All US states with the exception of Idaho, Utah, and Texas allow usage by non-native, non-enrolled persons in the context of ceremonies of the

. Some states such as Arizona additionally exempt any general bona fide religious activity or spiritual intent. US jurisdictions enacted these specific statutory exemptions in reaction to the

US Supreme Court The Supreme Court of the United States (SCOTUS) is the highest court in the federal judiciary of the United States. It has ultimate appellate jurisdiction over all U.S. federal court cases, and over state court cases that involve a point of ...

's decision in ''

Employment Division v. Smith ''Employment Division, Department of Human Resources of Oregon v. Smith'', 494 U.S. 872 (1990), is a United States Supreme Court case that held that the state could deny unemployment benefits to a person fired for violating a state prohibition on t ...

'', , which held that laws prohibiting the use of peyote that do not specifically exempt religious use nevertheless do not violate the

Free Exercise Clause The Free Exercise Clause accompanies the Establishment Clause of the First Amendment to the United States Constitution. The ''Establishment Clause'' and the ''Free Exercise Clause'' together read: Free exercise is the liberty of persons to re ...

of the

First Amendment First or 1st is the ordinal form of the number one (#1). First or 1st may also refer to: *World record, specifically the first instance of a particular achievement Arts and media Music * 1$T, American rapper, singer-songwriter, DJ, and reco ...

. Though use in Native American Church ceremonies or traditional Indian religious use, regardless of race, is legal under US federal law and additional uses are legal under some state laws, peyote is listed by the United States DEA as a Schedule I controlled substance. The US military prohibits inductees from enlistment for prior drug usage, however past usage of peyote is permissable if found to be used in accordance with Native American cultural practices.https://web.archive.org/web/20040712040446im_/http://usmilitary.about.com/library/pdf/navrecruit.pdf

References

External links

USDA: NRCS Plants Profile ''Lophophora williamsii''
{{Authority control Lophophora Entheogens Herbal and fungal hallucinogens Flora of the Chihuahuan Desert Flora of Texas Flora of New Mexico Flora of Northeastern Mexico Flora of the Rio Grande valleys Flora of Zacatecas Native American Church Native American religion Huichol Plants used in traditional Native American medicine Psychedelic phenethylamine carriers Religion and politics Cacti of the United States Cacti of Mexico Psychoactive cacti