Lidoflazine is a

piperazine Piperazine () is an organic compound that consists of a six-membered ring containing two nitrogen atoms at opposite positions in the ring. Piperazine exists as small alkaline deliquescent crystals with a saline taste. The piperazines are a broad ...

calcium channel blocker Calcium channel blockers (CCB), calcium channel antagonists or calcium antagonists are a group of medications that disrupt the movement of calcium () through calcium channels. Calcium channel blockers are used as antihypertensive drugs, i.e., as ...

. It is a coronary vasodilator with some antiarrhythmic action. Lidoflazine was discovered at

Janssen Pharmaceutica Janssen Pharmaceuticals is a pharmaceutical company headquartered in Beerse, Belgium, and wholly-owned by Johnson & Johnson. It was founded in 1953 by Paul Janssen. In 1961, Janssen Pharmaceuticals was purchased by New Jersey-based American c ...

in 1964.

Physical properties

Solubility at room temperature

Extracted from

Synthesis

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Ranolazine Ranolazine, sold under the brand name Ranexa among others, is a medication used to treat heart related chest pain. Typically it is used together with other medications when those are insufficient. Benefits appear smaller in women than men. It ...

Alkylation of N-carbethoxypiperazine 20-43-4(1) with 1- -chloro-1-(4-fluorophenyl)butyl4-fluorobenzene 312-04-7(2) give
CID:12679861
(3). Deprotection of which afforded 1- ,4-bis(4-fluorophenyl)butyliperazine 631-35-6 Acylation of 2,6-xylidine (4) with

chloroacetyl chloride Chloroacetyl chloride is a chlorinated acyl chloride. It is a bifunctional compound, making it a useful building block chemical. Production Industrially, it is produced by the carbonylation of methylene chloride, oxidation of vinylidene chlorid ...

(5) gives N-chloroacetyl-2,6-xylidine 131-01-7(6). The convergent synthesis between the above two counterparts completed the synthesis of lidoflazine (7).

Physical properties

Solubility at room temperature

Synthesis

References

Further reading