Lacing (drugs)
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Lacing or cutting, are drug slangs for the act of using a substance (referred to by the slang terms lacing agent or cutting agent) to adulterate substances independent of the reason. The resulting substance are refereed by the slang terms laced or cut. Some street drugs are commonly laced with other chemicals for various reasons, but it is most commonly done so as to bulk up the original product or to sell other, cheaper drugs in the place of something more expensive. Individuals sometimes lace their own drugs with another substance to combine or alter the physiological or psychoactive effects.


Types of lacing agents


Non-psychoactive lacing agents


Visually mimics

Some fake drugs consist of substances from relatively harmless sources, such as grocery store goods like
flour Flour is a powder made by grinding raw grains, roots, beans, nuts, or seeds. Flours are used to make many different foods. Cereal flour, particularly wheat flour, is the main ingredient of bread, which is a staple food for many cul ...
,
oregano Oregano (, ; ''Origanum vulgare'') is a species of flowering plant in the mint family Lamiaceae. It was native to the Mediterranean region, but widely naturalised elsewhere in the temperate Northern Hemisphere. Oregano is a woody perennial ...
or allergy pills. Even despite the substances' harmlessness, legal penalties for the crime of selling them can include time in jail.


Flavor masker

Sometimes a flavor masker are added to give a more pleasant experience.


Psychoactive mimics

Lacing/cutting agents may be psychoactive. Certain fake drugs include other controlled drugs, or they may include synthetic drugs with similar properties. Uncertainty of an identity of the substance may increase the risk of an overdose. A related, yet distinct, problem is the trade of
counterfeit medications A counterfeit medication or a counterfeit drug is a medication or pharmaceutical item which is produced and sold with the intent to deceptively represent its origin, authenticity, or effectiveness. A counterfeit drug may contain inappropriate qua ...
with pills including substances such as
fentanyl Fentanyl, also spelled fentanil, is a very potent synthetic opioid used as a pain medication. Together with other drugs, fentanyl is used for anesthesia. It is also used illicitly as a recreational drug, sometimes mixed with heroin, cocain ...
which can be used recreationally.


Reasons for lacing


Illegal drug trade

Drugs may be sold to end users who are unaware they have been laced or are unaware what was used to lace them. At various points in the supply chain, in order to maximize profitability, many drugs are adulterated with cutting agents. Substances with similar physical and/or chemical properties can be used so the end product most closely resembles what it is purported to be. Inert substances with similar physical properties can be used to increase weight without changing the look and feel. Less expensive or easier to obtain compounds with similar chemical properties may be used to lace heavily adulterated drugs while still maintaining some psychoactive potency.


Mickey Finn

In slang, a Mickey Finn—or simply a Mickey—is a
drink A drink or beverage is a liquid intended for human consumption. In addition to their basic function of satisfying thirst, drinks play important roles in human culture. Common types of drinks include plain drinking water, milk, juice, smoothies ...
laced with a
psychoactive drug A psychoactive drug, psychopharmaceutical, psychoactive agent or psychotropic drug is a chemical substance, that changes functions of the nervous system, and results in alterations in perception, mood, consciousness, cognition or behavior. ...
or
incapacitating agent The term incapacitating agent is defined by the United States Department of Defense as: :"An agent that produces temporary physiological or mental effects, or both, which will render individuals incapable of concerted effort in the performance of ...
(especially chloral hydrate) given to someone without their knowledge, with intent to incapacitate them.


Poly drug use

Drugs may also be laced with the end user being made aware of the lacing. In this case, rather than as an adulteration, the lacing is intended to make the product more desirable. Sometimes less potent, often less expensive drugs, are laced with a small amount of a more potent, often more expensive drug. This may be used to facilitate the ingestion of drugs or to allow the simultaneous ingestion of multiple drugs. Cigarettes laced with PCP allow users to take in the liquid PCP through smoking and some multi drug users report intentionally buying marijuana laced with methamphetamine.Meth-laced pot a huge problem, experts say
Canada.com January 27, 2006.


Commonly laced substances


Dietary supplements


CBD

* Cannabidiol (CBD) is often cut with synthetic cannabinoids.


Street drugs


Depressants


=Heroin

=
Heroin Heroin, also known as diacetylmorphine and diamorphine among other names, is a potent opioid mainly used as a recreational drug for its euphoric effects. Medical grade diamorphine is used as a pure hydrochloride salt. Various white and bro ...
is commonly cut with
quinine Quinine is a medication used to treat malaria and babesiosis. This includes the treatment of malaria due to '' Plasmodium falciparum'' that is resistant to chloroquine when artesunate is not available. While sometimes used for nocturnal leg ...
,
caffeine Caffeine is a central nervous system (CNS) stimulant of the methylxanthine chemical classification, class. It is mainly recreational drug use, used recreationally as a Nootropic, cognitive enhancer, increasing alertness and attentional perfor ...
, dimethocaine, lidocaine procaine,
lactose Lactose is a disaccharide sugar synthesized by galactose and glucose subunits and has the molecular formula C12H22O11. Lactose makes up around 2–8% of milk (by mass). The name comes from ' (gen. '), the Latin word for milk, plus the suffix ' ...
,
inositol Inositol, or more precisely ''myo''-inositol, is a carbocyclic sugar that is abundant in the brain and other mammalian tissues; it mediates cell signal transduction in response to a variety of hormones, neurotransmitters, and growth factors and ...
,
dextrose Glucose is a simple sugar with the molecular formula . Glucose is overall the most abundant monosaccharide, a subcategory of carbohydrates. Glucose is mainly made by plants and most algae during photosynthesis from water and carbon dioxide, usin ...
, mannitol, and
starch Starch or amylum is a polymeric carbohydrate consisting of numerous glucose units joined by glycosidic bonds. This polysaccharide is produced by most green plants for energy storage. Worldwide, it is the most common carbohydrate in human die ...
. Other
opioids Opioids are substances that act on opioid receptors to produce morphine-like effects. Medically they are primarily used for pain relief, including anesthesia. Other medical uses include suppression of diarrhea, replacement therapy for opioid u ...
are sometimes sold as heroin or cut with heroin. Fentanyl sold as or laced into heroin has made the news in the past due to the numerous fatalities it causes when it appears on the market. Recently, Fentanyl and close analogues have been produced in pure powder form for very cheap. Dealers may cut with or sell heroin with Fentanyl due to the street cost of Fentanyl versus the cost of heroin. The potency of such mixtures (especially if made carelessly) can be far above that of pure heroin, and users frequently overdose due to this. Gray death is a street drug in the United States. Samples have been found to contain the designer drug U-47700,
heroin Heroin, also known as diacetylmorphine and diamorphine among other names, is a potent opioid mainly used as a recreational drug for its euphoric effects. Medical grade diamorphine is used as a pure hydrochloride salt. Various white and bro ...
and
opioid Opioids are substances that act on opioid receptors to produce morphine-like effects. Medically they are primarily used for pain relief, including anesthesia. Other medical uses include suppression of diarrhea, replacement therapy for opioid use ...
s including
fentanyl Fentanyl, also spelled fentanil, is a very potent synthetic opioid used as a pain medication. Together with other drugs, fentanyl is used for anesthesia. It is also used illicitly as a recreational drug, sometimes mixed with heroin, cocain ...
and carfentanil.


Stimulants

Stimulants are drugs that speed or give a mental boost to the consumer.


=Cocaine

= Black cocaine, and
cocaine paste Coca paste (paco, basuco, oxi) is a crude extract of the coca leaf which contains 40% to 91% cocaine freebase along with companion coca alkaloids and varying quantities of benzoic acid, methanol, and kerosene. In South America, coca paste, also ...
, are impure forms of cocaine. The most common cocaine adulterants found in 1998 in samples in
Rome , established_title = Founded , established_date = 753 BC , founder = King Romulus ( legendary) , image_map = Map of comune of Rome (metropolitan city of Capital Rome, region Lazio, Italy).svg , map_caption ...
,
Italy Italy ( it, Italia ), officially the Italian Republic, ) or the Republic of Italy, is a country in Southern Europe. It is located in the middle of the Mediterranean Sea, and its territory largely coincides with the homonymous geographical ...
were lidocaine and
caffeine Caffeine is a central nervous system (CNS) stimulant of the methylxanthine chemical classification, class. It is mainly recreational drug use, used recreationally as a Nootropic, cognitive enhancer, increasing alertness and attentional perfor ...
.
Cocaine Cocaine (from , from , ultimately from Quechua: ''kúka'') is a central nervous system (CNS) stimulant mainly used recreationally for its euphoric effects. It is primarily obtained from the leaves of two Coca species native to South Am ...
is sometimes mixed with
methylamphetamine Methylamphetamine may refer to: * Phentermine, α-methylamphetamine *2-Phenyl-3-aminobutane, β-methylamphetamine *Methamphetamine, ''N''-methylamphetamine **Methamphetamine hydrochloride, "crystal meth" *Ortetamine, 2-methylamphetamine *3-Methylam ...
,
methylphenidate Methylphenidate, sold under the brand names Ritalin and Concerta among others, is the most widely prescribed central nervous system (CNS) stimulant medication used to treat attention deficit hyperactivity disorder (ADHD) and, to a lesser extent ...
, and ephedrine, but is usually mixed with non psychoactive chemicals such as mannitol,
inositol Inositol, or more precisely ''myo''-inositol, is a carbocyclic sugar that is abundant in the brain and other mammalian tissues; it mediates cell signal transduction in response to a variety of hormones, neurotransmitters, and growth factors and ...
,
pectin Pectin ( grc, πηκτικός ': "congealed" and "curdled") is a heteropolysaccharide, a structural acid contained in the primary lamella, in the middle lamella, and in the cell walls of terrestrial plants. The principal, chemical component o ...
,
glucose Glucose is a simple sugar with the molecular formula . Glucose is overall the most abundant monosaccharide, a subcategory of carbohydrates. Glucose is mainly made by plants and most algae during photosynthesis from water and carbon dioxide, u ...
,
lactose Lactose is a disaccharide sugar synthesized by galactose and glucose subunits and has the molecular formula C12H22O11. Lactose makes up around 2–8% of milk (by mass). The name comes from ' (gen. '), the Latin word for milk, plus the suffix ' ...
, saccharin, white rice flour, and maltodextrin. Other of
agranulocytosis Agranulocytosis, also known as agranulosis or granulopenia, is an acute condition involving a severe and dangerous lowered white blood cell count (leukopenia, most commonly of neutrophils) and thus causing a neutropenia in the circulating blood. ...
, including 2 deaths, according to an alert from the Substance Abuse and Mental Health Services Administration (SAMHSA). The emergence of
fentanyl Fentanyl, also spelled fentanil, is a very potent synthetic opioid used as a pain medication. Together with other drugs, fentanyl is used for anesthesia. It is also used illicitly as a recreational drug, sometimes mixed with heroin, cocain ...
-laced cocaine has led to an increase in cocaine overdose fatalities in New York City.


=Methamphetamine

= MSM is sometimes used as a cutting agent for illicitly manufactured
methamphetamine Methamphetamine (contracted from ) is a potent central nervous system (CNS) stimulant that is mainly used as a recreational drug and less commonly as a second-line treatment for attention deficit hyperactivity disorder and obesity. Methamp ...
.


Psychedelics


=Cannabis

= Cannabis products that are laced are usually laced with synthetic cannabinoids: * Counterfeit cannabis-liquid (c-liquid) for
e-cigarette An electronic cigarette is an electronic device that simulates tobacco smoking. It consists of an atomizer, a power source such as a battery, and a container such as a cartridge or tank. Instead of smoke, the user inhales vapor. As such ...
s: Synthetic cannabinoids are increasingly offered in e-cigarette form as "c-liquid". * Counterfeit
cannabis ''Cannabis'' () is a genus of flowering plants in the family Cannabaceae. The number of species within the genus is disputed. Three species may be recognized: '' Cannabis sativa'', '' C. indica'', and '' C. ruderalis''. Alternative ...
buds: Hemp buds (or low-potency cannabis buds) laced with synthetic cannabinoids. * Counterfeit cannabis edible: The Florida Poison Information Center in Jacksonville warned parents in September 2020 that the number of people poisoned by fake marijuana edibles and candies has tripled. * Counterfeit hash oil: Several school kids in Greater Manchester collapsed after vaping synthetic cannabinoids mis-sold as THC vape. * Counterfeit
hashish Hashish ( ar, حشيش, ()), also known as hash, "dry herb, hay" is a drug made by compressing and processing parts of the cannabis plant, typically focusing on flowering buds (female flowers) containing the most trichomes. European Monitoring ...
: In 2020 counterfeit
hashish Hashish ( ar, حشيش, ()), also known as hash, "dry herb, hay" is a drug made by compressing and processing parts of the cannabis plant, typically focusing on flowering buds (female flowers) containing the most trichomes. European Monitoring ...
were found to contain 4F-MDMB-BINACA and 5F-MDMB-PINACA (5F-ADB). Less common psychoactive substances used to adulterate cannabis: * Erectile dysfunction drugs: In the Netherlands two chemical analogs of
Sildenafil Sildenafil, sold under the brand name Viagra, among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. It is unclear if it is effective for treating sexual dysfunction in women. It is taken by ...
(
Viagra Sildenafil, sold under the brand name Viagra, among others, is a medication used to treat erectile dysfunction and pulmonary arterial hypertension. It is unclear if it is effective for treating sexual dysfunction in women. It is taken by ...
) were found in adulterated
marijuana Cannabis, also known as marijuana among other names, is a psychoactive drug from the cannabis plant. Native to Central or South Asia, the cannabis plant has been used as a drug for both recreational and entheogenic purposes and in various t ...
. *
Methamphetamine Methamphetamine (contracted from ) is a potent central nervous system (CNS) stimulant that is mainly used as a recreational drug and less commonly as a second-line treatment for attention deficit hyperactivity disorder and obesity. Methamp ...
: psychiatrist Dr Bill MacEwan believes that drug dealers in British Columbia are intentionally lacing cannabis with methamphetamine to make it more addictive. He had some psychiatric patients that claimed they only smoked
pot Pot may refer to: Containers * Flowerpot, a container in which plants are cultivated * Pottery, ceramic ware made by potters * A type of cookware Places * Ken Jones Aerodrome, IATA airport code POT * Palestinian Occupied Territories, the W ...
but their drug tests were positive for methamphetamine use. * PCP: Rarely, cannabis (especially that of low quality) is laced with PCP, particularly in the
United States The United States of America (U.S.A. or USA), commonly known as the United States (U.S. or US) or America, is a country Continental United States, primarily located in North America. It consists of 50 U.S. state, states, a Washington, D.C., ...
. However, it is not always done surreptitiously. Dealers who do so often (but not always) advertise their wares as being "enhanced" with other substances, and charge more money than they would otherwise, even if they do not say exactly what the lacing agents are. Such concoctions are often called "fry", "wet", "illy", "sherm", "water-water", "dust(ed)", "super weed", "grecodine" or other names. Weight cutting agents: * Binding substances: Sometimes cannabis is adulterated with other binding substances including industrial glues such as
neoprene Neoprene (also polychloroprene) is a family of synthetic rubbers that are produced by polymerization of chloroprene.Werner Obrecht, Jean-Pierre Lambert, Michael Happ, Christiane Oppenheimer-Stix, John Dunn and Ralf Krüger "Rubber, 4. Emulsion R ...
,
tar Tar is a dark brown or black viscous liquid of hydrocarbons and free carbon, obtained from a wide variety of organic materials through destructive distillation. Tar can be produced from coal, wood, petroleum, or peat. "a dark brown or black bi ...
,
ammonia Ammonia is an inorganic compound of nitrogen and hydrogen with the formula . A stable binary hydride, and the simplest pnictogen hydride, ammonia is a colourless gas with a distinct pungent smell. Biologically, it is a common nitrogenous ...
,
bitumen Asphalt, also known as bitumen (, ), is a sticky, black, highly viscous liquid or semi-solid form of petroleum. It may be found in natural deposits or may be a refined product, and is classed as a pitch. Before the 20th century, the term a ...
, petroleum-derived
hydrocarbons In organic chemistry, a hydrocarbon is an organic compound consisting entirely of hydrogen and carbon. Hydrocarbons are examples of group 14 hydrides. Hydrocarbons are generally colourless and hydrophobic, and their odors are usually weak or ...
, dog food or even human or animal excrement. to make it cheaper, thus being of poorer quality. * Sand, sugar, brix fertilizers, hair spray, fertilizers, pesticides and fungicides. * Microscopic glass beads: Cannabis buds was found to be contaminated with glass beads in 2007, known as ''gris weed''. *
Lead Lead is a chemical element with the symbol Pb (from the Latin ) and atomic number 82. It is a heavy metal that is denser than most common materials. Lead is soft and malleable, and also has a relatively low melting point. When freshly cut, ...
: In 2008, 30 German teenagers were hospitalized after the marijuana which they smoked was found to have been contaminated with lead (presumably metallic lead particles), which was added in order to increase its weight. *
Shoe polish Shoe polish (or boot polish) is a waxy paste, cream, or liquid that is used to polish, shine, and waterproof leather shoes or boots to extend the footwear's life and restore its appearance. Shoe polishes are distinguished by their textures, ...
: Hash has been cut with shoe polish. * Tocopheryl acetate: See 2019–20 vaping lung illness outbreak.


=Ecstasy

= Black market ecstasy pills are frequently found to contain other drugs in place of or in addition to methylenedioxymethylamphetamine (MDMA). Since the slang term "ecstasy" usually refers only to MDMA, any pill which contains other compounds may be considered adulterated. 3,4-Methylenedioxyamphetamine (MDA), methylenedioxyethamphetamine (MDEA),
amphetamine Amphetamine (contracted from alpha- methylphenethylamine) is a strong central nervous system (CNS) stimulant that is used in the treatment of attention deficit hyperactivity disorder (ADHD), narcolepsy, and obesity. It is also commonly used ...
,
methylamphetamine Methylamphetamine may refer to: * Phentermine, α-methylamphetamine *2-Phenyl-3-aminobutane, β-methylamphetamine *Methamphetamine, ''N''-methylamphetamine **Methamphetamine hydrochloride, "crystal meth" *Ortetamine, 2-methylamphetamine *3-Methylam ...
, benzylpiperazine (BZP),
trifluoromethylphenylpiperazine 3-Trifluoromethylphenylpiperazine (TFMPP) is a recreational drug of the piperazine chemical class. Usually in combination with benzylpiperazine (BZP) and other analogues, it is sold as an alternative to the illicit drug MDMA ("Ecstasy"). Pharma ...
(TFMPP),
caffeine Caffeine is a central nervous system (CNS) stimulant of the methylxanthine chemical classification, class. It is mainly recreational drug use, used recreationally as a Nootropic, cognitive enhancer, increasing alertness and attentional perfor ...
, ephedrine,
pseudoephedrine Pseudoephedrine (PSE) is a sympathomimetic drug of the phenethylamine and amphetamine chemical classes. It may be used as a nasal/sinus decongestant, as a stimulant, or as a wakefulness-promoting agent in higher doses. It was first charact ...
, and
dextromethorphan Dextromethorphan (DXM) is a medication most often used as a cough suppressant in over-the-counter cold and cough medicines. It is sold in syrup, tablet, spray, and lozenge forms. In 2022, the FDA approved a formulation of it combined with b ...
(DXM) are all commonly found in pills being sold as ecstasy. Less common drugs in ecstasy include
diphenhydramine Diphenhydramine (DPH) is an antihistamine and sedative mainly used to treat allergies, insomnia, and symptoms of the common cold. It is also less commonly used for tremor in parkinsonism, and nausea. It is taken by mouth, injected into ...
,
acetaminophen Paracetamol, also known as acetaminophen, is a medication used to treat fever and mild to moderate pain. Common brand names include Tylenol and Panadol. At a standard dose, paracetamol only slightly decreases body temperature; it is inferior ...
,
5-MeO-DiPT 5-Methoxy-''N'',''N''-diisopropyltryptamine (5-MeO-DiPT, sometimes called Foxy Methoxy or simply Foxy) is a psychedelic tryptamine and the methoxy derivative of diisopropyltryptamine (DiPT). Pharmacology The mechanism that produces the purport ...
, 2C-B, procaine, and phencyclidine (PCP). Ecstasy pills sometimes contain dimethylamylamine to increase its stimulant effects. Ecstasy pills might also contain a low dose of 2C-I to potentiate its euphoric effects. Pharmaceutical pills are sometimes sold as ecstasy, as well as pills that contain no psychoactive chemicals at all. Ecstasy sometimes contains 10 mg to 20 mg of baclofen to reduce overheating caused by ecstasy. ''para''-Methoxyamphetamine (PMA or "Dr. Death", a drug that causes so much overheating that it can kill within 40 minutes) is sometimes sold as ecstasy. There is one published case of an ecstasy tablet being adulterated with 8 mg of
strychnine Strychnine (, , US chiefly ) is a highly toxic, colorless, bitter, crystalline alkaloid used as a pesticide, particularly for killing small vertebrates such as birds and rodents. Strychnine, when inhaled, swallowed, or absorbed through the e ...
, a toxic
alkaloid Alkaloids are a class of basic, naturally occurring organic compounds that contain at least one nitrogen atom. This group also includes some related compounds with neutral and even weakly acidic properties. Some synthetic compounds of simila ...
which was used in very low doses (less than 1 mg) as a stimulant and performance-enhancing drug in the past. Recently, several groups advocating for drug safety through education have made reagent testing products available to confirm what substances there are.


=LSD

= LSD is virtually never laced with other chemicals, but other lysergamides such as ALD-52 are sometimes sold as LSD-25. DOB, DOI, and other closely related drugs are sometimes sold as LSD. Several other highly potent hallucinogens such as Bromo-DragonFLY or 25I-NBOMe can be found in the form of blotters. LSD is also tasteless in normal dosages, so detection is only possible after ingestion or reagent testing. For these reasons, it is not uncommon to find blotters sold as LSD completely devoid of psychoactive substances.


Prescription medication

As the sources of prescription medication on the street are not verifiable through legitimate channels, misrepresentation of prescription medications is a common practice.


Case reports in commercial products


Alcohol

In June 2022, the ''Dutch Food and Consumer Product Safety Authority'' warned that the 3-liter champagne bottle from Moët & Chandon Ice Impérial contained MDMA, killing a person in Germany.


Testing


Reagent testing

Reagent testing kits are available online and also sold at some head shops. These kits claim to be able to identify common adulterants in ecstasy.


Professional lab tests

There are services available for testing the contents of an ecstasy pill that can tell the user what chemicals are contained in the pill and at what ratio. The results are then posted on their website along with every other pill that they have tested. The tests are considered to be highly accurate. Their services were at one time free, but when they ran out of funding they had to charge a fee for every pill tested.


See also

*
Cutting agent A cutting agent is a chemical used to "cut" ( dilute or adulterate) recreational drugs with something less expensive than the drug itself. Overview The classical model of drug cutting, according to Preble and Casey (1969), refers to the way ...
* Date rape drug *
Pill testing Drug checking or pill testing is a way to reduce the harm from drug consumption by allowing users to find out the content and purity of substances that they intend to consume. This empowers users to make safer choices: to avoid more dangerous substa ...
*
Darknet market A darknet market is a commercial website on the dark web that operates via darknets such as Tor or I2P. They function primarily as black markets, selling or brokering transactions involving drugs, cyber-arms, weapons, counterfeit currency, sto ...


References

{{DEFAULTSORT:Lacing (Drugs) Drug culture Adulteration