Jonathan Felix Ashmore (born 1948) is a British

physicist A physicist is a scientist who specializes in the field of physics, which encompasses the interactions of matter and energy at all length and time scales in the physical universe. Physicists generally are interested in the root or ultimate cau ...

and Bernard Katz Professor of

Biophysics Biophysics is an interdisciplinary science that applies approaches and methods traditionally used in physics to study biological phenomena. Biophysics covers all scales of biological organization, from molecular to organismic and populations. ...

University College London , mottoeng = Let all come who by merit deserve the most reward , established = , type = Public research university , endowment = £143 million (2020) , budget = ...

Early life and education

He is the son of

Rosalie Crutchley Rosalie Sylvia Crutchley (4 January 1920 – 28 July 1997) was a British actress. Trained at the Royal Academy of Music, Crutchley was perhaps best known for her television performances, but had a long and successful career in theatre and films, ...

who played

Madame Defarge Madame Thérèse Defarge is a fictional character and the main antagonist of the 1859 novel ''A Tale of Two Cities'' by Charles Dickens. She is a ringleader of the tricoteuses, a tireless worker for the French Revolution, memorably knitting besi ...

A Tale of Two Cities ''A Tale of Two Cities'' is a historical novel published in 1859 by Charles Dickens, set in London and Paris before and during the French Revolution. The novel tells the story of the French Doctor Manette, his 18-year-long imprisonment in ...

. Ashmore was educated at

Westminster School (God Gives the Increase) , established = Earliest records date from the 14th century, refounded in 1560 , type = Public school Independent day and boarding school , religion = Church of England , head_label = Hea ...

as a Queen's Scholar. He studied mathematics and physics at the

University of Sussex , mottoeng = Be Still and Know , established = , type = Public research university , endowment = £14.4 million (2020) , budget = £319.6 million (2019–20) , chancellor = Sanjeev Bhaskar , vice_chancellor = Sasha Roseneil , ...

followed by a PhD in

theoretical physics Theoretical physics is a branch of physics that employs mathematical models and abstractions of physical objects and systems to rationalize, explain and predict natural phenomena. This is in contrast to experimental physics, which uses experim ...

in 1971 supervised by

Tom Kibble Sir Thomas Walter Bannerman Kibble (; 23 December 1932 – 2 June 2016) was a British theoretical physicist, senior research investigator at the Blackett Laboratory and Emeritus Professor of Theoretical Physics at Imperial College London. His ...

Imperial College London Imperial College London (legally Imperial College of Science, Technology and Medicine) is a public research university in London, United Kingdom. Its history began with Prince Albert, consort of Queen Victoria, who developed his vision for a cu ...

where his research investigated quantum field theory.

Career and research

After a short

postdoctoral A postdoctoral fellow, postdoctoral researcher, or simply postdoc, is a person professionally conducting research after the completion of their doctoral studies (typically a PhD). The ultimate goal of a postdoctoral research position is to pu ...

research fellow A research fellow is an academic research position at a university or a similar research institution, usually for academic staff or faculty members. A research fellow may act either as an independent investigator or under the supervision of a pr ...

ship supervised by

Abdus Salam Mohammad Abdus Salam Salam adopted the forename "Mohammad" in 1974 in response to the anti-Ahmadiyya decrees in Pakistan, similarly he grew his beard. (; ; 29 January 192621 November 1996) was a Punjabi Pakistani theoretical physicist and a ...

at the

International Centre for Theoretical Physics The Abdus Salam International Centre for Theoretical Physics (ICTP) is an international research institute for physical and mathematical sciences that operates under a tripartite agreement between the Italian Government, United Nations Educatio ...

Trieste Trieste ( , ; sl, Trst ; german: Triest ) is a city and seaport in northeastern Italy. It is the capital city, and largest city, of the autonomous region of Friuli Venezia Giulia, one of two autonomous regions which are not subdivided into prov ...

, Italy he retrained as a physiologist at UCL, gaining a

Master of Science A Master of Science ( la, Magisterii Scientiae; abbreviated MS, M.S., MSc, M.Sc., SM, S.M., ScM or Sc.M.) is a master's degree in the field of science awarded by universities in many countries or a person holding such a degree. In contrast t ...

degree in 1974 which led to work with

Paul Fatt Paul Fatt (13 January 1924 – 28 September 2014) was a British neuroscientist, who was a professor at University College London. With Bernard Katz, he developed the "quantal hypothesis" for neurotransmitters. Personal life Paul married thre ...

and Gertrude Falk between 1974 and 1977 in the Biophysics Department. Ashmore was appointed a Lecturer in

Physiology Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemical ...

at the

University of Bristol , mottoeng = earningpromotes one's innate power (from Horace, ''Ode 4.4'') , established = 1595 – Merchant Venturers School1876 – University College, Bristol1909 – received royal charter , type ...

in 1983 and promoted to

Reader A reader is a person who reads. It may also refer to: Computing and technology * Adobe Reader (now Adobe Acrobat), a PDF reader * Bible Reader for Palm, a discontinued PDA application * A card reader, for extracting data from various forms of ...

in 1988, before moving back to UCL in 1993. Ashmore has worked on dissecting the cellular mechanisms of hearing by studying the

organ of Corti The organ of Corti, or spiral organ, is the receptor organ for hearing and is located in the mammalian cochlea. This highly varied strip of epithelial cells allows for transduction of auditory signals into nerve impulses' action potential. Transd ...

in the mammalian

cochlea The cochlea is the part of the inner ear involved in hearing. It is a spiral-shaped cavity in the bony labyrinth, in humans making 2.75 turns around its axis, the modiolus. A core component of the cochlea is the Organ of Corti, the sensory or ...

especially the guinea pig (''Cavia porcellus''). This structure in the inner ear increases the selectivity and sensitivity of our hearing through an in-built cochlear amplifier. He showed that specialised cells known as

outer hair cell Hair cells are the sensory receptors of both the auditory system and the vestibular system in the ears of all vertebrates, and in the lateral line organ of fishes. Through mechanotransduction, hair cells detect movement in their environment. ...

s are responsible for this unique function. In response to sound, outer hair cells lengthen then shorten through a process controlled and powered by the flow of electrically charged molecules such as

potassium Potassium is the chemical element with the symbol K (from Neo-Latin ''kalium'') and atomic number19. Potassium is a silvery-white metal that is soft enough to be cut with a knife with little force. Potassium metal reacts rapidly with atmosph ...

ion An ion () is an atom or molecule with a net electrical charge. The charge of an electron is considered to be negative by convention and this charge is equal and opposite to the charge of a proton, which is considered to be positive by conve ...

s. This contraction propagates and amplifies sound, and he was the first to capture it on film during his '' Rock Around the Clock Hair Cell'' video. His work has combined biophysical methods – including the

patch clamp The patch clamp technique is a laboratory technique in electrophysiology used to study ionic currents in individual isolated living cells, tissue sections, or patches of cell membrane. The technique is especially useful in the study of excita ...

technique usually applied to

membrane protein Membrane proteins are common proteins that are part of, or interact with, biological membranes. Membrane proteins fall into several broad categories depending on their location. Integral membrane proteins are a permanent part of a cell membrane ...

s – with

confocal microscopy Confocal microscopy, most frequently confocal laser scanning microscopy (CLSM) or laser confocal scanning microscopy (LCSM), is an optical imaging technique for increasing optical resolution and contrast of a micrograph by means of using a s ...

imaging and

computational model A computational model uses computer programs to simulate and study complex systems using an algorithmic or mechanistic approach and is widely used in a diverse range of fields spanning from physics, chemistry and biology to economics, psychology, ...

ling to expand our knowledge of hearing at the molecular and cellular level. His findings are helping to unravel the nature and origins of hearing-related conditions like

deafness Deafness has varying definitions in cultural and medical contexts. In medical contexts, the meaning of deafness is hearing loss that precludes a person from understanding spoken language, an audiological condition. In this context it is written ...

and

tinnitus Tinnitus is the perception of sound when no corresponding external sound is present. Nearly everyone experiences a faint "normal tinnitus" in a completely quiet room; but it is of concern only if it is bothersome, interferes with normal hearin ...

. One or more of the preceding sentences incorporates text from the royalsociety.org website where: His research has been funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and the Medical Research Council (MRC) and he has supervised several doctoral students to completion including Dan Jagger.

Awards and honours

Ashmore was elected a

Fellow of the Royal Society Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the judges of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural knowledge, including mathemat ...

(FRS) in 1996 and gave their

Croonian Lecture The Croonian Medal and Lecture is a prestigious award, a medal, and lecture given at the invitation of the Royal Society and the Royal College of Physicians. Among the papers of William Croone at his death in 1684, was a plan to endow a single ...

in 2017 on the

neuroscience Neuroscience is the scientific study of the nervous system (the brain, spinal cord, and peripheral nervous system), its functions and disorders. It is a multidisciplinary science that combines physiology, anatomy, molecular biology, developme ...

.Ashmore, Jonathan (2017) He is also an elected

Fellow of the Academy of Medical Sciences Fellowship of the Academy of Medical Sciences (FMedSci) is an award for medical scientists who are judged by the UK Academy of Medical Sciences for the "excellence of their science, their contribution to medicine and society and the range of th ...

(FMedSci), a

Fellow of the Royal Society of Biology Fellowship of the Royal Society of Biology (FRSB), previously Fellowship of the Society of Biology (FSB), is an award and fellowship granted to individuals that the Royal Society of Biology has adjudged to have made a "prominent contribution to ...

(FRSB) and a member of both the

Association for Research in Otolaryngology The Association for Research in Otolaryngology is a professional association of researchers, including practitioners, teachers, and students, in the fields of otolaryngology (ear, nose, and throat), and especially including hearing. Journal JARO ...

and The Biophysical Society. Ashmore is

Faculty of 1000 F1000 (formerly "Faculty of 1000") is an open research publisher for scientists, scholars, and clinical researchers. F1000 offers a different research evaluation service from standard academic journals by offering peer-review after, rather than b ...

section head for Sensory Systems and a trustee for the Hearing Research Trust. He served as President of

The Physiological Society The Physiological Society, founded in 1876, is a learned society for physiologists in the United Kingdom. History The Physiological Society was founded in 1876 as a dining society "for mutual benefit and protection" by a group of 19 physiologis ...

from 2012 to 2014.

Personal life

Ashmore is the son of actor Peter Ashmore and actress

. Aged seven, Ashmore played Joe in the 1955 film '' A Kid for Two Farthings'', adapted from the novel by

Wolf Mankowitz Cyril Wolf Mankowitz (7 November 1924 – 20 May 1998) was an English writer, playwright and screenwriter. He is particularly known for three novels— '' Make Me an Offer'' (1952), '' A Kid for Two Farthings'' (1953) and ''My Old Man's a Dustm ...

References

{{DEFAULTSORT:Ashmore, Jonathan Felix Living people Academics of University College London Academics of the University of Bristol Alumni of Imperial College London British physicists Fellows of the Royal Society Fellows of the Royal Society of Biology Fellows of the Academy of Medical Sciences (United Kingdom) 1948 births Presidents of The Physiological Society