History Of Pharmacology

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The history of pharmacy as an independent science dates back to the first third of the 19th century. Before then, pharmacy evolved from antiquity as part of medicine. The history of pharmacy coincides well with the history of medicine, but it's important that there is a distinction between the two topics. Pharmaceuticals is one of the most-researched fields in the academic industry, but the history surrounding that particular topic is sparse compared to the impact its made world-wide. Before the advent of pharmacists, there existed apothecaries that worked alongside priests and physicians in regard to patient care.

Pharmacy in Rome, Italy

Prehistoric Pharmacy

Paleopharmacological studies attest to the use of medicinal plants in pre-history.^[1] For example, herbs were discovered in the Shanidar Cave, and remains of the areca nut (Areca catechu) in the Spirit Cave.^[2]^:8 Prehistoric man learned pharmaceutical techniques through instinct, by watching birds and beasts, and using cool water, leaves, dirt, or mud as a soothing agent.^[3]

Antiquity

Mesopotamia and Egypt

Sumerian cuneiform tablets record prescriptions for medicine.^[4] Ancient Egyptian pharmacological knowledge was recorded in various papyri such as the Ebers Papyrus of 1550 BC and it included a 1,100 page document about 800 prescriptions using 700 drugs mostly derived from plants^[5], and the Edwin Smith Papyrus of the 16th century BC.

The very beginnings or pharmaceutical texts were written on clay tablets by Mesopotamians. Some texts included formulas, instructions via pulverization, infusion, boiling, filtering and spreading; herbs were mentioned as well.^[6] Babylon, a state within Mesopotamia, provided the earliest known practice of running an apothecary i.e. pharmacy. Alongside the ill person included a priest, physician, and a pharmacist to

Antiquity

Mesopotamia and Egypt

Greece

Dioscorides, De Materia Medica, Byzantium, 15th century

Greece

The earliest known Chinese manual on materia medica is the Shennong Bencao Jing (The Divine Farmer's Herb-Root Classic), dati

From 60 and 78 AD,^[2]^:21–22 the Greek physician Pedanius Dioscorides wrote a five volume book, De Materia Medica, covering over 600 plants and coining the term materia medica. It formed the basis for many medieval texts, and was built upon by many middle eastern scientists during the Islamic Golden Age.^[2]^:21–22

The earliest known Chinese manual on materia medica is the Shennong Bencao Jing (The Divine Farmer's Herb-Root Classic), dating back to the 1st century AD. It was compiled during the Han dynasty and was attributed to the mythical Shennong. Earlier literature included lists of prescriptions for specific ailments, exemplified by a manuscript "Recipes for 52 Ailments", found in the Mawangdui, sealed in 168 BC. Further details on Chinese pharmacy can be found in the Pharmacy in China article.

The earliest known compilation of medicinal substances in Indian traditional medicine dates to the 3rd or 4th century AD )(attributed to Sushruta, who is recorded as a physician of the 6th century BC).

There is a stone sign for a pharmacy with a tripod, a mortar, and a pestle opposite one for a doctor in the Arcadian Way in Ephesus, Turkey.^{[citation needed]}

In Japan, at the end of the Asuka period (538-710) and the early Nara period (710-794), the men who fulfilled roles similar to those of modern pharmacists were highly respected. The place of pharmacists in society was expressly defined in the Taihō Code (701) and re-stated in the Yōrō Code (718). Ranked positions in the pre-Heian Imperial court were established; and this organizational structure remained largely intact until the Meiji Restoration (1868). In this highly stable hierarchy, the pharmacists—and even pharmacist assistants—were assigned status superior to all others in health-related fields such as physicians and acupuncturists. In the Imperial household, the pharmacist was even ranked above the two personal physicians of the Emperor.^[9]

In Baghdad the first pharmacies, or drug stores, were established in 754,^[10] under the Abbasid Caliphate during the Islamic Golden Age. By the 9th century, these pharmacies were state-regulated.^[11]

The advances made in the Middle East in botany and chemistry led medicine in medieval Islam substantially to develop pharmacology. Muhammad ibn Zakarīya Rāzi (Rhazes) (865-915), for instance, acted to promote the medical uses of chemical compounds. Abu al-Qasim al-Zahrawi (Abulcasis) (936-1013) pioneered the preparation of medicines by sublimation and distillation. His Liber servitoris is of particular interest, as it provides the reader with recipes and explains how to prepare the "simples" from which were compounded the complex drugs then generally used. Sabur Ibn Sahl (d 869), was, however, the first physician to initiate pharmacopoedia, describing a large variety of drugs and remedies for ailments. Al-Biruni (973-1050) wrote one of the most valuable Islamic works on pharmacology entitled Kitab al-Saydalah (The Book of Drugs), where he gave detailed knowledge of the properties of drugs and outlined the role of pharmacy and the functions and duties of the pharmacist. Ibn Sina (Avicenna), too, described no less than 700 preparations, their properties, mode of action and their indications. He devoted in fact a whole volume to simple drugs in The Canon of Medicine. Of great impact were also the works by al-Maridini of Baghdad and Cairo, and Ibn al-Wafid (1008–1074), both of which were printed in Latin more than fifty times, appearing as De Medicinis universalibus et particularibus by `Mesue' the younger, and the Medicamentis Simplicibus by `Abenguefit'. Peter of Abano (1250–1316) translated and added a supplement to the work of al-Maridini under the title De Veneris. Al-Muwaffaq's contributions in the field are also pioneering. Living in the 10th century, he wrote The Foundations of the True Properties of Remedies, amongst others describing arsenious oxide, and being acquainted with silicic acid. He made clear distinction between sodium carbonate and potassium carbonate, and drew attention to the poisonous nature of copper compounds, especially copper vitriol, and also lead compounds. He also describes the distillation of sea-water for drinking.^[12]

Europe

Western Roman Empire, medicinal knowledge in Europe suffered due to the loss of Greek medicinal texts and a strict adherence to tradition, although an area of Southern Italy near Salerno remained under Byzantine control and developed a hospital and medical school, which became famous by the 11th century.^[2]^:30

In the early 11th century, Salerno scholar Constantinos Africanus translated many Arabic books into Latin, driving a shift from Hippocratic medicine towards a pharmaceutical-driven approach advocated by Galen.^[2]^:30 In medieval Europe, monks typically did not speak Greek, leaving only Latin texts such as the works of Pliny available until these translations by Constantinos.^[2]^:30 In addition, Arabic medicine became more widely known due to Muslim Spain.^[2]^:30

In the 15th century, the printing press spread medicinal textbooks and formularies; the Antidotarium was the first printed drug formulary.^[2]^{In the early 11th century, Salerno scholar Constantinos Africanus translated many Arabic books into Latin, driving a shift from Hippocratic medicine towards a pharmaceutical-driven approach advocated by Galen.^[2]^:30 In medieval Europe, monks typically did not speak Greek, leaving only Latin texts such as the works of Pliny available until these translations by Constantinos.^[2]^:30 In addition, Arabic medicine became more widely known due to Muslim Spain.^[2]^:30}

In the 15th century, the printing press spread medicinal textbooks and formularies; the Antidotarium was the first printed drug formulary.^[2]^:30

In Europe pharmacy-like shops began to appear during the 12th century. In 1240 emperor Frederic II issued a decree by which the physician's and the apothecary's professions were separated.^[5]

Old pharmacies continue to operate in Dubrovnik, Croatia located inside the Franciscan monastery, opened in 1317^{[citation needed]}. The Town Hall Pharmacy in Tallinn, Estonia, which dates back to at least 1422, is the oldest continuously run pharmacy in the world still operating in the original premises.^[13]

The trend towards pharmacy specialization started to take effect in Bruges, Belgium where a new law was passed that forbid physicians to prepare medications for patients.^[14]

The oldest pharmacy is claimed to be set up in 1221 in the Church of Santa Maria Novella in Florence, Italy, which now houses a perfume museum. The medieval Esteve Pharmacy, located in Llívia, a Catalan enclave close to Puigcerdà, is also now a museum dating back to the 15th century, keeping albarellos from the 16th and 17th centuries, old prescription books and antique drugs. Florence is also the birthplace of the first official pharmacopeia, called the Nuevo Receptario, in which all pharmacies would use that document as guidance for caring for the sickly.^[3]

The Republic of Venice was the first State with health modern policies which requires that the nature of the drug is public. In actuality, thirteen secrets survive which were offered to sale to the Venetian Republic.^[15]

The 1800s brought increased technical sophistication. By the late 1880s, German dye manufacturers had perfected the purification of individual organic compounds from tar and other mineral sources and had also established rudimentary methods in organic chemical synthesis.^[16]

Chloral hydrate was introduced as a sleeping aid and sedative in 1869.^[17] Chloroform was first used as an anesthetic in 1847.^[18]

Derivatives of phenothiazines had an important impact on various aspects of medicine, beginning with methylene blue which was originally used as a dye after its synthesis from aniline in 1876.^[19] Phenothiazines were used as antimalarials, antiseptics, and antihelminthics up to 1940.^[20] 1950, chlorpromazine was discovered, which began the "psychopharmacological revolution".^{phenothiazines had an important impact on various aspects of medicine, beginning with methylene blue which was originally used as a dye after its synthesis from aniline in 1876.^[19] Phenothiazines were used as antimalarials, antiseptics, and antihelminthics up to 1940.^[20] 1950, chlorpromazine was discovered, which began the "psychopharmacological revolution".^[20]}

The United States formed the American Pharmaceutical Association in 1852^[21] with its main purpose to advance pharmacists' roles in patient care, assist in furthering career development, spread information about tools and resources, and raising awareness about the roles of pharmacists and their contribution to patient care. ^[22]

Frederick Banting and Charles Best showed through dogs that the hormone Insulin lowered their blood sugar and started the catalyst that James B. Collip finished. Collip developed pure insulin used for human testing and dramatically changed the prospects for all diabetics.

Alexander Fleming developed the first antibiotic, penicillin, after discovering a fungus that was able to kill off bacteria. ^[23]