MTB may refer to:

Science and medicine

* Magnetotactic bacteria * Mediterranean tamarisk beetle * Multilobular tumour of bone, canine disease * ''Mycobacterium tuberculosis''

Transport and vehicles

* Matlock Bath railway station, England; National Rail station code MTB * Mississauga Truck and Bus Collision, a Canadian bus manufacturer * Motor torpedo boat * Mountain bike

Other uses

*''Magandang Tanghali Bayan'', a variety show in the Philippines * M&T Bank of New York, NYSE symbol * My Therapy Buddy, a talking plush doll for adults {{disambiguation