Encarnación (Spanish pronunciation: [eŋkaɾnaˈsjon]) is a district and the capital city of Itapúa Department in Paraguay, located at the south-east of the department, on the right-hand (western) shore of the Paraná River, opposite Posadas, Argentina. The city has an area of 274 km² and a population of 93,497 (2002 Census). Encarnación is the third-largest city of Paraguay.
Encarnación is connected to the Argentine city of Posadas by the San Roque González de Santa Cruz Bridge and the International Train. The city is located on Route 1, some 370 km (225 miles) from Asunción, and located on Route 6, some 280 km (175 miles) from Ciudad del Este.
The Teniente Amin Ayub Gonzalez Airport (IATA: ENO, ICAO: SGEN), at coordinates 27°13′23″S 55°50′03″W, is 12 kilometres from the city, is the third most important airport of the country.