DEOXYRIBOSE, or more precisely 2-DEOXYRIBOSE, is a monosaccharide with idealized formula H−(C=O)−(CH2)−(CHOH)3−H. Its name indicates that it is a deoxy sugar , meaning that it is derived from the sugar ribose by loss of an oxygen atom. Since the pentose sugars arabinose and ribose only differ by the stereochemistry at C2′, 2-deoxyribose and 2-deoxyarabinose are equivalent, although the latter term is rarely used because ribose, not arabinose, is the precursor to deoxyribose.
* 1 History * 2 Structure
* 3 Biological importance
* 3.1 Biosynthesis
* 4 References
Several isomers exist with the formula
H−(C=O)−(CH2)−(CHOH)3−H, but in deoxyribose all the hydroxyl
groups are on the same side in the
Fischer projection . The term
"2-deoxyribose" may refer to either of two enantiomers : the
biologically important D-2-deoxyribose and to the rarely encountered
mirror image L-2-deoxyribose . D-2-deoxyribose is a precursor to the
In aqueous solution, deoxyribose primarily exists as a mixture of three structures: the linear form H−(C=O)−(CH2)−(CHOH)3−H and two ring forms, deoxyribofuranose ("C3′-endo"), with a five-membered ring, and deoxyribopyranose ("C2′-endo"), with a six-membered ring. The latter form is predominant (whereas the C3′-endo form is favored for ribose). Chemical equilibrium of deoxyribose in solution
As a component of DNA, 2-deoxyribose derivatives have an important
role in biology. The
The absence of the 2′ hydroxyl group in deoxyribose is apparently
responsible for the increased mechanical flexibility of
Other biologically important derivatives of deoxyribose include mono-, di-, and triphosphates, as well as 3′-5′ cyclic monophosphates.
Look up DEOXYRIBOSE or DESOXYRIBOSE in Wiktionary, the free dictionary.
* ^ The Merck Index: An Encyclopedia of Chemicals, Drugs, and
Biologicals (11th ed.), Merck, 1989, ISBN 091191028X , 2890
* ^ "Comprehensive Timeline of Biological Discoveries" (PDF).
Retrieved 31 July 2017.
* ^ C Bernelot-Moens and B Demple (1989), Multiple
* v * t * e
Types of carbohydrates
* Deoxy sugars
* Deoxy sugars