The Core binding factor (CBF) is a group of
heterodimeric
In biochemistry, a protein dimer is a macromolecular complex or multimer formed by two protein monomers, or single proteins, which are usually non-covalently bound. Many macromolecules, such as proteins or nucleic acids, form dimers. The word ...
transcription factor
In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription (genetics), transcription of genetics, genetic information from DNA to messenger RNA, by binding t ...
s.
Core binding factors are composed of:
* a non-
DNA
Deoxyribonucleic acid (; DNA) is a polymer composed of two polynucleotide chains that coil around each other to form a double helix. The polymer carries genetic instructions for the development, functioning, growth and reproduction of al ...
-binding CBFβ chain (
CBFB
Core-binding factor subunit beta is a protein that in humans is encoded by the ''CBFB'' gene.
The protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription fact ...
)
* a DNA-binding CBFα chain (
RUNX1
Runt-related transcription factor 1 (RUNX1) also known as acute myeloid leukemia 1 protein (AML1) or core-binding factor subunit alpha-2 (CBFA2) and it is a protein that is encoded by the ''RUNX1'' gene, in humans.
RUNX1 is a transcription facto ...
,
RUNX2
Runt-related transcription factor 2 (RUNX2) also known as core-binding factor subunit alpha-1 (CBF-alpha-1) is a protein that in humans is encoded by the ''RUNX2'' gene. RUNX2 is a key transcription factor associated with osteoblast differentia ...
,
RUNX3
Runt-related transcription factor 3 is a protein that in humans is encoded by the ''RUNX3'' gene.
Function
This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta sub ...
)
References
*
See also
*
AI-10-49, an anti-leukemic drug under development.
External links
*
Transcription factors
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