Butaperazine (Repoise, Tyrylen) is a

typical antipsychotic Typical antipsychotics (also known as major tranquilizers, and first generation antipsychotics) are a class of antipsychotic drugs first developed in the 1950s and used to treat psychosis (in particular, schizophrenia). Typical antipsychotics ma ...

of the

phenothiazine Phenothiazine, abbreviated PTZ, is an organic compound that has the formula S(C6H4)2NH and is related to the thiazine-class of heterocyclic compounds. Derivatives of phenothiazine are highly bioactive and have widespread use and rich history. T ...

class. It was approved in 1967, and possibly discontinued in the 1980s.

Synthesis

2-Butyrylphenothiazine 5244-91-1(1) is the requisite starting material for carrying out the procedure. It is prepared in a manner that is synonymous with the method used in the propiomazine and propiopromazine already discussed. The 1-(γ-chloropropyl)-4-methylpiperazine 04-16-5(2) is prepared in the conventional way from alkylating

1-methylpiperazine ''N''-Methylpiperazine is a heterocyclic organic compound. Uses ''N''-Methylpiperazine is a common building block used in organic synthesis. For example, ''N''-methylpiperazine is used in the manufacture of various pharmaceutical drugs includin ...

and

1-Bromo-3-chloropropane 1-Bromo-3-chloropropane is an organohalogen compound with the formula Br(CH2)3Cl. It is a colorless liquid, produced by free-radical addition of hydrogen bromide to allyl chloride. It is used as an alkylating agent to install the –(CH2)3Cl an ...

. Sodamide is used to extract the 10-H thereby facilitating the nucleophilic substitution reaction. And completing the instalment of the sidechain.

References

Phenothiazines Piperazines Aromatic ketones Typical antipsychotics Propyl compounds {{nervous-system-drug-stub

Synthesis

See also

References