An antiflatulent (or deflatulent) agent is a drug used for the alleviation or prevention of excessive intestinal gas, i.e., flatulence.

Mechanisms of action

Preventing gas

* Enzymes –

Enzyme Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products ...

-based dietary supplements break down indigestible substances and prevent these substances from reaching the

large intestine The large intestine, also known as the large bowel, is the last part of the gastrointestinal tract and of the digestive system in tetrapods. Water is absorbed here and the remaining waste material is stored in the rectum as feces before bein ...

intact – where anaerobic

bacteria Bacteria (; singular: bacterium) are ubiquitous, mostly free-living organisms often consisting of one Cell (biology), biological cell. They constitute a large domain (biology), domain of prokaryotic microorganisms. Typically a few micrometr ...

produce gas. Substances indigestible by humans are usually present in foods associated with flatulence, like beans. When these substances reach the large intestine intact, they may be fermented by intestinal bacteria, thereby causing gas production. These supplements are usually taken with foods associated with flatulence. It is important to take the appropriate enzyme with the appropriate food. When consuming beans and other vegetables high in complex carbohydrates, it may be helpful to take a product that contains

alpha-galactosidase α-Galactosidase ( EC 3.2.1.22, α-GAL, α-GAL A; systematic name α-D-galactoside galactohydrolase) is a glycoside hydrolase enzyme that catalyses the following reaction: : Hydrolysis of terminal, non-reducing α-D-galactose residues in α-D ...

, such as Beano or

kombu ''Konbu'' (from ja, 昆布, konbu or kombu) is edible kelp mostly from the family Laminariaceae and is widely eaten in East Asia. It may also be referred to as ''dasima'' ( ko, 다시마) or ''haidai'' (). Kelp features in the diets of many ...

. Additionally, for individuals with

lactose intolerance Lactose intolerance is a common condition caused by a decreased ability to digest lactose, a sugar found in dairy products. Those affected vary in the amount of lactose they can tolerate before symptoms develop. Symptoms may include abdominal pai ...

, taking a

lactase Lactase is an enzyme produced by many organisms. It is located in the brush border of the small intestine of humans and other mammals. Lactase is essential to the complete digestion of whole milk; it breaks down lactose, a sugar which gives ...

-containing product with lactose-containing foodstuffs may reduce flatulence. * Herbal inhibitors – Many herbal substances have been observed since antiquity for reducing flatulence, particularly gas from eating legumes. Cloves,

nutmeg Nutmeg is the seed or ground spice of several species of the genus ''Myristica''. ''Myristica fragrans'' (fragrant nutmeg or true nutmeg) is a dark-leaved evergreen tree cultivated for two spices derived from its fruit: nutmeg, from its seed, an ...

, cinnamon, and garlic are potent in reducing gas. The potency of garlic increases when heated, whereas the potency of cinnamon decreases. Other spices have a lesser effect in reducing gas, including

turmeric Turmeric () is a flowering plant, ''Curcuma longa'' (), of the ginger family, Zingiberaceae, the rhizomes of which are used in cooking. The plant is a perennial, rhizomatous, herbaceous plant native to the Indian subcontinent and Southeast ...

black pepper Black pepper (''Piper nigrum'') is a flowering vine in the family Piperaceae, cultivated for its fruit, known as a peppercorn, which is usually dried and used as a spice and seasoning. The fruit is a drupe (stonefruit) which is about in dia ...

asafoetida Asafoetida (; also spelled asafetida) is the dried latex ( gum oleoresin) exuded from the rhizome or tap root of several species of ''Ferula'', perennial herbs growing tall. They are part of the celery family, Umbelliferae. Asafoetida is th ...

and ginger. Other common Indian spices, cumin,

aniseed Anise (; '), also called aniseed or rarely anix is a flowering plant in the family Apiaceae native to Eurasia. The flavor and aroma of its seeds have similarities with some other spices and herbs, such as star anise, fennel, licorice, and t ...

ajowan Ajwain, ajowan (), or ''Trachyspermum ammi''—also known as ajowancaraway, omam (in Tamil), thymol seeds, bishop's weed, or carom—is an annual herb in the family Apiaceae. Both the leaves and the seed‑like fruit (often mistakenly called s ...

, and

cardamom Cardamom (), sometimes cardamon or cardamum, is a spice made from the seeds of several plants in the genera ''Elettaria'' and ''Amomum'' in the family Zingiberaceae. Both genera are native to the Indian subcontinent and Indonesia. They are r ...

do ''not'' inhibit gas production, in fact they exacerbate it significantly.A. Savitri, T. N. Bhavanishankar and H. S. R. Desikachar.
Effect of spices on in vitro gas production by Clostridium perfringens
Food Microbiology, 1986, 3, 195-199

Relieving gas

For the ''alleviation'' of flatulence, an antifoaming agent such as

simethicone Simeticone ( INN), also known as simethicone (USAN), is an anti-foaming agent used to reduce bloating, discomfort or pain caused by excessive gas. Medical uses Simeticone is used to relieve the symptoms of excessive gas in the gastrointestina ...

may be taken orally. This agent will coalesce the smaller gas bubbles into larger bubbles, thereby easing the release of gas within the gastrointestinal tract via

burping Burping (also called belching and eructation) is the release of gas from the upper digestive tract (esophagus and stomach) of animals through the mouth. It is usually audible. In humans, burping can be caused by normal eating processes, or as ...

or flatulence.

Classification

Antifoaming agents

Simethicone Simeticone ( INN), also known as simethicone (USAN), is an anti-foaming agent used to reduce bloating, discomfort or pain caused by excessive gas. Medical uses Simeticone is used to relieve the symptoms of excessive gas in the gastrointestina ...

(also marketed under the name "Gas-X" in some countries)

Enzyme-based dietary supplements

* Beano *

Lactase Lactase is an enzyme produced by many organisms. It is located in the brush border of the small intestine of humans and other mammals. Lactase is essential to the complete digestion of whole milk; it breaks down lactose, a sugar which gives ...

(brand Lactaid)

Herbal antiflatulents

Epazote ''Dysphania ambrosioides'', formerly ''Chenopodium ambrosioides'', known as Jesuit's tea, Mexican-tea, ''payqu'' ''(paico)'', ''epazote'', ''mastruz'', or ''herba sanctæ Mariæ'', is an annual or short-lived perennial herb native to Central A ...

is claimed to have antiflatulent properties. *

Asafoetida Asafoetida (; also spelled asafetida) is the dried latex ( gum oleoresin) exuded from the rhizome or tap root of several species of ''Ferula'', perennial herbs growing tall. They are part of the celery family, Umbelliferae. Asafoetida is th ...

reduces the growth of indigenous microflora in the gut thereby reducing flatulence.S. K. GARG, A. C. BANERJEA, J. VERMA. and M. J. ABRAHAM, EFFECT OF VARIOUS TREATMENTS OF PULSES ON IN VITRO GAS PRODUCTION BY SELECTED INTESTINAL CLOSTRIDIA. Journal of Food Science, Volume 45, Issue 6 (p 1601-1602).

References

External links

*{{Commonscatinline, Antiflatulents