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ALBERT HOFMANN (11 January 1906 – 29 April 2008) was a Swiss scientist known best for being the first person to synthesize , ingest , and learn of the psychedelic effects of lysergic acid diethylamide (LSD). Hofmann was also the first person to isolate, synthesize, and name the principal psychedelic mushroom compounds psilocybin and psilocin . He authored more than 100 scientific articles and numerous books, including LSD: Mein Sorgenkind (LSD: My Problem Child). In 2007, he shared first place, alongside Tim Berners-Lee
Tim Berners-Lee
, in a list of the 100 greatest living geniuses, published by The Telegraph newspaper.

CONTENTS

* 1 Life and career

* 1.1 Discovery of LSD * 1.2 Further research * 1.3 Later years * 1.4 Disposition of Hofmann\'s papers

* 2 Death * 3 Honors and awards * 4 See also * 5 References * 6 Further reading * 7 External links

LIFE AND CAREER

Hofmann was born in Baden, Switzerland
Baden, Switzerland
, the first of four children to factory toolmaker Adolf Hofmann and his wife Elisabeth (born Elisabeth Schenk). Owing to his father's low income, Albert's godfather paid for his education. When his father became ill, Hofmann obtained a position as a commercial apprentice in concurrence with his studies. At the age of twenty, Hofmann began his chemistry degree at the University of Zürich
University of Zürich
, finishing three years later, in 1929. His main interest was the chemistry of plants and animals, and he later conducted important research on the chemical structure of the common animal substance chitin , for which he received his doctorate , with distinction, in the spring of 1929.

Regarding his decision to pursue a career as a chemist, Hofmann provided insight during a speech he delivered to the 1996 Worlds of Consciousness Conference in Heidelberg, Germany:

One often asks oneself what roles planning and chance play in the realization of the most important events in our lives. This decision was not easy for me. I had already taken a Latin matricular exam, and therefore a career in the humanities stood out most prominently in the foreground. Moreover, an artistic career was tempting. In the end, however, it was a problem of theoretical knowledge which induced me to study chemistry, which was a great surprise to all who knew me. Mystical experiences in childhood, in which Nature was altered in magical ways, had provoked questions concerning the essence of the external, material world, and chemistry was the scientific field which might afford insights into this.

DISCOVERY OF LSD

Main article: Discovery of LSD

Hofmann became an employee of the pharmaceutical-chemical department of Sandoz
Sandoz
Laboratories (now a subsidiary of Novartis
Novartis
), located in Basel
Basel
as a co-worker with professor Arthur Stoll , founder and director of the pharmaceutical department. He began studying the medicinal plant squill and the fungus ergot as part of a program to purify and synthesize active constituents for use as pharmaceuticals . His main contribution was to elucidate the chemical structure of the common nucleus of the Scilla
Scilla
glycosides (an active principal of Mediterranean Squill ). While researching lysergic acid derivatives, Hofmann first synthesized LSD on 16 November 1938. The main intention of the synthesis was to obtain a respiratory and circulatory stimulant (an analeptic ) with no effects on the uterus in analogy to nikethamide (which is also a diethylamide) by introducing this functional group to lysergic acid . It was set aside for five years, until 16 April 1943, when Hofmann decided to reexamine it. While re-synthesizing LSD, he accidentally touched his hand to his mouth, nose or possibly eye, ingesting a small amount and discovered its powerful effects. He described what he felt as being:

... affected by a remarkable restlessness, combined with a slight dizziness. At home I lay down and sank into a not unpleasant intoxicatedlike condition, characterized by an extremely stimulated imagination. In a dreamlike state, with eyes closed (I found the daylight to be unpleasantly glaring), I perceived an uninterrupted stream of fantastic pictures, extraordinary shapes with intense, kaleidoscopic play of colors. After some two hours this condition faded away.

Three days later, on 19 April 1943 , Hofmann intentionally ingested 250 micrograms of LSD. This day is now known as "Bicycle Day", because he began to feel the effects of the drug as he rode home on a bike. This was the first intentional LSD trip.

Hofmann continued to take small doses of LSD throughout much of his life, and always hoped to find a use for it. In his memoir, he emphasized it as a "sacred drug": "I see the true importance of LSD in the possibility of providing material aid to meditation aimed at the mystical experience of a deeper, comprehensive reality."

FURTHER RESEARCH

“ It gave me an inner joy, an open mindedness, a gratefulness, open eyes and an internal sensitivity for the miracles of creation. I think that in human evolution it has never been as necessary to have this substance LSD. It is just a tool to turn us into what we are supposed to be. ”

— Albert Hofmann, Speech on 100th birthday

Hofmann, later, was to discover 4-Acetoxy-DET (4-acetoxy-N,N-diethyltryptamine), also known as ethacetin, ethylacybin, or 4-AcO-DET, a hallucinogenic tryptamine . He first synthesized 4-AcO-DET in 1958 in the Sandoz
Sandoz
lab. Hofmann became director of the natural products department at Sandoz
Sandoz
and continued studying hallucinogenic substances found in Mexican mushrooms and other plants used by the aboriginal people there. This led to the synthesis of psilocybin , the active agent of many "magic mushrooms ." Hofmann also became interested in the seeds of the Mexican morning glory species Turbina corymbosa
Turbina corymbosa
, the seeds of which are called ololiuhqui by the natives. He was surprised to find the active compound of ololiuhqui , ergine (LSA, lysergic acid amide), to be closely related to LSD.

In 1962, he and his wife Anita Hofmann (née Guanella, sister of Gustav Guanella , an important Swiss inventor) traveled to southern Mexico
Mexico
to search for the plant "Ska Maria Pastora" (Leaves of Mary the Shepherdess), later known as Salvia divinorum
Salvia divinorum
. He was able to obtain samples of this plant, but never succeeded in identifying its active compound, which has since been identified as the diterpenoid salvinorin A . In 1963, Hofmann attended the annual convention of the World Academy of Arts and Sciences (WAAS) in Stockholm
Stockholm
.

LATER YEARS

Albert Hofmann
Albert Hofmann
in 2006

Hofmann, interviewed shortly before his hundredth birthday, called LSD "medicine for the soul" and was frustrated by the worldwide prohibition of it. "It was used very successfully for ten years in psychoanalysis," he said, adding that the drug was misused by the Counterculture
Counterculture
of the 1960s , and then criticized unfairly by the political establishment of the day. He conceded that it could be dangerous if misused, because a relatively high dose of 500 micrograms will have an extremely powerful psychoactive effect, especially if administered to a first-time user without adequate supervision.

In December 2007, Swiss medical authorities permitted psychotherapist Peter Gasser to perform psychotherapeutic experiments with patients who suffer from terminal-stage cancer and other deadly diseases. Completed in 2011, these experiments represent the first study of the therapeutic effects of LSD on humans in 35 years, as other studies have focused on the drug's effects on consciousness and body. Hofmann acclaimed the study, and continued to say he believed in the therapeutic benefits of LSD. In 2008, Hofmann wrote to Steve Jobs
Steve Jobs
, asking him to support this research; it is not known if Jobs responded. The Multidisciplinary Association of Psychedelic Studies (MAPS) has supported research in the field of psychoanalysis using LSD, carrying on Hofmann's legacy and setting the groundwork for future studies.

Hofmann was due to speak at the World Psychedelic Forum from 21 to 24 March 2008 but was forced to cancel because of bad health.

James Fadiman confirmed that Hofmann was microdosing LSD for at least the last two decades of his life.

Hofmann was also a long-time friend and correspondent of German author and entomologist Ernst Jünger
Ernst Jünger
, whom he met in 1949. Jünger experimented with LSD with Hofmann; in 1970, Jünger published a book of his experiences taking several types of drugs, Annäherungen. Drogen und Rausch (Approaches: Drugs and Intoxication).

DISPOSITION OF HOFMANN\'S PAPERS

After retiring from Sandoz
Sandoz
in 1971, Hofmann was allowed to take his papers and research home. He gave his archives to the Albert Hofmann Foundation, a Los Angeles-based nonprofit, but the documents mostly sat in storage for years. The archives were sent to the San Francisco area in 2002 to be digitized, but that process was never completed. In 2013, the archives were sent to the Institute of Medical History in Bern, Switzerland, where they are currently being organized.

DEATH

Hofmann died of a heart attack on 29 April 2008, surrounded by several grandchildren and great-grandchildren. He and his wife, Anita, who died in 2007, raised four children.

HONORS AND AWARDS

The Swiss Federal Institute of Technology ( ETH Zurich
ETH Zurich
) honored him with the title D.Sc. (honoris causa) in 1969 together with Gustav Guanella , his brother-in-law. In 1971 the Swedish Pharmaceutical Association (Sveriges Farmacevtförbund) granted him the Scheele Award , which commemorates the skills and achievements of the Swedish Pomeranian chemist and pharmacist Carl Wilhelm Scheele.

SEE ALSO

* Lysergic acid diethylamide
Lysergic acid diethylamide
* History of lysergic acid diethylamide
History of lysergic acid diethylamide
* Psychedelic therapy * Timothy Leary
Timothy Leary
* Owsley Stanley
Owsley Stanley
* Drug design
Drug design
* Alexander Shulgin
Alexander Shulgin
* James Fadiman

REFERENCES

* ^ "Albert Hofmannf". Multidisciplinary Association for Psychedelic Studies. Archived from the original on 30 April 2008. Retrieved 29 April 2008. * ^ A B "Obituary: Albert Hofmann, LSD inventor". London: Daily Telegraph. 29 April 2008. Archived from the original on 1 May 2008. Retrieved 29 April 2008. * ^ Hofmann, A. " Psilocybin
Psilocybin
und Psilocin, zwei psychotrope Wirkstoffe aus mexikanischen Rauschpilzen." Helvetica Chemica Acta 42: 1557–1572 (1959). * ^ "Top 100 living geniuses". The Daily Telegraph. London. 30 October 2007. * ^ Dieter Hagenbach; Lucius Werthmüller; Stanislav Grof (2013). Mystic Chemist: The Life of Albert Hofmann
Albert Hofmann
and His Discovery of LSD (First English ed.). Santa Fe, NM: Synergetic Press. p. 16. ISBN 978-0-907791-46-1 . * ^ Hoffman, Albert; J. Ott (1996). "LSD: Completely Personal". Newsletter of the Multidisciplinary Association for Psychedelic Studies. 6 (3). Retrieved 7 November 2013. * ^ A B "LSD, My Problem Child". psychedelic-library.org. Retrieved 16 November 2009. * ^ Dr. Albert Hofmann; translated from the original German (LSD Ganz Persönlich) by J. Ott. MAPS-Volume 6 Number 69 Summer 1969 * ^ "LSD inventor Albert Hofmann
Albert Hofmann
dies". BBC News
BBC News
. 30 April 2008. * ^ Hofmann 1980, p. 15 * ^ http://blog.oup.com/2013/04/bicycle-day-lsd-albert-hoffman/ * ^ Roberts, Jacob (2017). "High Times". Distillations. 2 (4): 36–39. Retrieved 24 July 2017. * ^ "LSD: The Geek\'s Wonder Drug?". Wired.com. 16 January 2006. Retrieved 29 April 2008. * ^ Bleidt, Barry; Michael Montagne (1996). Clinical Research in Pharmaceutical Development. Informa Health Care . pp. 36, 42–43. ISBN 0-8247-9745-0 . * ^ Smith, Craig S. (7 Ja