Aceclofenac
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Aceclofenac is a
nonsteroidal anti-inflammatory drug Non-steroidal anti-inflammatory drugs (NSAID) are members of a therapeutic drug class which reduces pain, decreases inflammation, decreases fever, and prevents blood clots. Side effects depend on the specific drug, its dose and duration of ...
(NSAID) analog of diclofenac. It is used for the relief of pain and inflammation in rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. It was patented in 1983 and approved for medical use in 1992.


Side effects

Aceclofenac should not be given to people with porphyria or breast-feeding mothers, and is not recommended for children. It should be avoided near term in a pregnant woman because of the risk of having a
premature closure of ductus arteriosus leading to fetal hydrops Premature may refer to: * ''Premature'' (2014 film), an American comedy film * ''Premature'' (2019 film), an American romantic drama film * ''PREMature'', a 2015 British television drama miniseries See also * Premature aging, of an organism * P ...
in the neonate.


Chemistry

Aceclofenac (C16H13Cl2NO4), chemically 2- phenylacetooxyacetic acid is a crystalline powder with a molecular weight of 354.19. It is practically insoluble in water with good permeability. It is metabolized in human hepatocytes and human microsomes to form -(2',6'-dichloro-4'-hydroxy- phenylamino) phenylacetoxyacetic acid as the major metabolite, which is then further conjugated. According to the Biopharmaceutical Classification System (BCS) drug substances are classified to four classes upon their solubility and permeability. Aceclofenac falls under the BCS Class II, poorly soluble and highly permeable drug. Aceclofenac works by inhibiting the action of cyclooxygenase (COX) that is involved in the production of prostaglandins (PG) which is accountable for pain, swelling, inflammation and fever. The incidence of gastric ulcerogenicity of aceclofenac has been reported to be significantly lower than that of the other frequently prescribed NSAIDs, for instance, 2-folds lesser than naproxen, 4-folds lesser than diclofenac, and 7-folds lesser than
indomethacin Indometacin, also known as indomethacin, is a nonsteroidal anti-inflammatory drug (NSAID) commonly used as a prescription drug, prescription medication to reduce fever, pain, joint stiffness, stiffness, and swelling (medical), swelling from infl ...
.


Society and culture


Economics

Aceclofenac is available in Hungary as a
prescription only medicine A prescription drug (also prescription medication or prescription medicine) is a pharmaceutical drug that legally requires a medical prescription to be dispensed. In contrast, over-the-counter drugs can be obtained without a prescription. The rea ...
. The cost of the drug is low, around US$0.14 per 100 mg tablet ().


Brand names

Aceclofenac is available in Europe and
CIS Cis or cis- may refer to: Places * Cis, Trentino, in Italy * In Poland: ** Cis, Świętokrzyskie Voivodeship, south-central ** Cis, Warmian-Masurian Voivodeship, north Math, science and biology * cis (mathematics) (cis(''θ'')), a trigonome ...
countries. Known trades names include: Acecgen (Generics UK), Aflamin (
Gedeon Richter Plc. Gedeon Richter Plc. is a Hungarian multinational pharmaceutical and biotechnology company headquartered in Budapest, Hungary. It is one of the largest companies of the industry in the Central and Eastern European region and has operations in ov ...
), AklofEP (ExtractumPharma) and Flemac (Aramis Pharma).


References


Citations


General and cited sources

* ''British National Formulary 55'', March 2008; , p. 537


External links

* Anilines Acetic acids Chloroarenes Carboxylate esters Nonsteroidal anti-inflammatory drugs {{analgesic-stub