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Ankylosing Spondylitis
Ankylosing spondylitis (AS) is a type of arthritis characterized by long-term inflammation of the joints of the spine typically where the spine joins the pelvis. Occasionally areas affected may include other joints such as the shoulders or hips, eye and bowel problems may occur as well as back pain. Joint mobility in the affected areas generally worsens over time. Although the cause of ankylosing spondylitis is unknown, it is believed to involve a combination of genetic and environmental factors. More than 85% of those affected in the UK have a specific human leukocyte antigen known as the HLA-B27 antigen. The underlying mechanism is believed to be autoimmune or autoinflammatory. Diagnosis is typically based on the symptoms with support from medical imaging and blood tests. AS is a type of seronegative spondyloarthropathy, meaning that tests show no presence of rheumatoid factor (RF) antibodies. There is no known cure for AS. Treatments may include medication, exercise, ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Vertebrae
The spinal column, a defining synapomorphy shared by nearly all vertebrates,Hagfish are believed to have secondarily lost their spinal column is a moderately flexible series of vertebrae (singular vertebra), each constituting a characteristic irregular bone whose complex structure is composed primarily of bone, and secondarily of hyaline cartilage. They show variation in the proportion contributed by these two tissue types; such variations correlate on one hand with the cerebral/caudal rank (i.e., location within the vertebral column, backbone), and on the other with phylogenetic differences among the vertebrate taxon, taxa. The basic configuration of a vertebra varies, but the bone is its ''body'', with the central part of the body constituting the ''centrum''. The upper (closer to) and lower (further from), respectively, the cranium and its central nervous system surfaces of the vertebra body support attachment to the intervertebral discs. The posterior part of a vertebra fo ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Blood Tests
A blood test is a laboratory analysis performed on a blood sample that is usually extracted from a vein in the arm using a hypodermic needle, or via fingerprick. Multiple tests for specific blood components, such as a glucose test or a cholesterol test, are often grouped together into one test panel called a blood panel or blood work. Blood tests are often used in health care to determine physiological and biochemical states, such as disease, mineral content, pharmaceutical drug effectiveness, and organ function. Typical clinical blood panels include a basic metabolic panel or a complete blood count. Blood tests are also used in drug tests to detect drug abuse. Extraction A venipuncture is useful as it is a minimally invasive way to obtain cells and extracellular fluid (plasma) from the body for analysis. Blood flows throughout the body, acting as a medium that provides oxygen and nutrients to tissues and carries waste products back to the excretory systems for disposal. Conseq ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Ectasia
Ectasia (), also called ectasis (), is dilation or distention of a tubular structure, either normal or pathophysiologic but usually the latter (except in atelectasis, where absence of ectasis is the problem). Specific conditions * Bronchiectasis, chronic dilatation of the bronchi * Duct ectasia of breast, a dilated milk duct. Duct ectasia syndrome is a synonym for nonpuerperal (unrelated to pregnancy and breastfeeding) mastitis. * Dural ectasia, dilation of the dural sac surrounding the spinal cord, usually in the very low back. * Pyelectasis, dilation of a part of the kidney, most frequently seen in prenatal ultrasounds. It usually resolves on its own. * Rete tubular ectasia, dilation of tubular structures in the testicles. It is usually found in older men. * Acral arteriolar ectasia * Corneal ectasia (secondary keratoconus), a bulging of the cornea. ;Vascular ectasias * Most broadly, any abnormal dilatation of a blood vessel, including aneurysms * Annuloaortic ectasia, dil ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Enthesopathy
An enthesopathy refers to a disorder involving the attachment of a tendon or ligament to a bone. This site of attachment is known as the enthesis (pl. entheses). If the condition is known to be inflammatory, it can more precisely be called an enthesitis. Forms Enthesopathy can occur at the shoulder, elbow, wrist, carpus, hip, knee, ankle, tarsus, or heel bone, among other regions. Enthesopathies may take the form of spondyloarthropathies (joint diseases of the spine) such as ankylosing spondylitis, plantar fasciitis, and Achilles tendinitis. Further examples include: * Adhesive capsulitis of shoulder * Rotator cuff syndrome of shoulder and allied disorders * Periarthritis of shoulder * Scapulohumeral fibrositis * Synovitis of hand or wrist * Periarthritis of wrist * Gluteal tendinitis * Iliac crest spur * Psoas tendinitis * Trochanteric tendinitis Causes Generalized involvement of the entheses with calcification of tendon and ligament insertions and of joint capsules has bee ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Calcaneal Spur
A calcaneal spur (also known as a heel spur) is a bony outgrowth from the calcaneal tuberosity (heel bone). Calcaneal spurs are typically detected by x-ray examination. It is a form of exostosis. When a foot is exposed to constant stress, calcium deposits build up on the bottom of the heel bone. Generally, this has no effect on a person's daily life. However, repeated damage can cause these deposits to pile up on each other, causing a spur-shaped deformity, called a calcaneal (or heel) spur. An inferior calcaneal spur is located on the inferior aspect of the calcaneus and is typically a response to plantar fasciitis over a period, but may also be associated with ankylosing spondylitis (typically in children). A posterior calcaneal spur develops on the back of the heel at the insertion of the Achilles tendon. An inferior calcaneal spur consists of a calcification of the calcaneus, which lies superior to the plantar fascia at the insertion of the plantar fascia. A posterior calcane ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sacroiliac Joint
The sacroiliac joint or SI joint (SIJ) is the joint between the sacrum and the ilium bones of the pelvis, which are connected by strong ligaments. In humans, the sacrum supports the spine and is supported in turn by an ilium on each side. The joint is strong, supporting the entire weight of the upper body. It is a synovial plane joint with irregular elevations and depressions that produce interlocking of the two bones. The human body has two sacroiliac joints, one on the left and one on the right, that often match each other but are highly variable from person to person. Structure Sacroiliac joints are paired C-shaped or L-shaped joints capable of a small amount of movement (2–18 degrees, which is debatable at this time) that are formed between the auricular surfaces of the sacrum and the ilium bones. However mostBogduk, Nicolai "Clinical and Radiological Anatomy of the Lumbar Spine" Elsevier Health Sciences, 2022, p. 172. agree that there are only slight movements occu ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Anatomical Terms Of Motion
Motion, the process of movement, is described using specific anatomical terms. Motion includes movement of organs, joints, limbs, and specific sections of the body. The terminology used describes this motion according to its direction relative to the anatomical position of the body parts involved. Anatomists and others use a unified set of terms to describe most of the movements, although other, more specialized terms are necessary for describing unique movements such as those of the hands, feet, and eyes. In general, motion is classified according to the anatomical plane it occurs in. ''Flexion'' and ''extension'' are examples of ''angular'' motions, in which two axes of a joint are brought closer together or moved further apart. ''Rotational'' motion may occur at other joints, for example the shoulder, and are described as ''internal'' or ''external''. Other terms, such as ''elevation'' and ''depression'', describe movement above or below the horizontal plane. Many anatomica ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Gluteal Muscles
The gluteal muscles, often called glutes are a group of three muscles which make up the gluteal region commonly known as the buttocks: the gluteus maximus, gluteus medius and gluteus minimus. The three muscles originate from the ilium and sacrum and insert on the femur. The functions of the muscles include extension, abduction, external rotation, and internal rotation of the hip joint. Structure The gluteus maximus is the largest and most superficial of the three gluteal muscles. It makes up a large part of the shape and appearance of the hips. It is a narrow and thick fleshy mass of a quadrilateral shape, and forms the prominence of the buttocks. The gluteus medius is a broad, thick, radiating muscle, situated on the outer surface of the pelvis. It lies profound to the gluteus maximus and its posterior third is covered by the gluteus maximus, its anterior two-thirds by the gluteal aponeurosis, which separates it from the superficial fascia and skin. The gluteus minimus is ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Chronic (medicine)
A chronic condition is a health condition or disease that is persistent or otherwise long-lasting in its effects or a disease that comes with time. The term ''chronic'' is often applied when the course of the disease lasts for more than three months. Common chronic diseases include diabetes, functional gastrointestinal disorder, eczema, arthritis, asthma, cancer, chronic obstructive pulmonary disease, Lyme disease, autoimmune diseases, genetic disorders and some viral diseases such as hepatitis C and acquired immunodeficiency syndrome. An illness which is lifelong because it ends in death is a terminal illness. It is possible and not unexpected for an illness to change in definition from terminal to chronic. Diabetes and HIV for example were once terminal yet are now considered chronic due to the availability of insulin for diabetics and daily drug treatment for individuals with HIV which allow these individuals to live while managing symptoms. In medicine, ''chronic'' condition ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Blausen 0037 AnkylosingSpondylitis
Blausen Medical Communications, Inc. is the creator and owner of a library of two- and three-dimensional medical and scientific images and animations, a developer of information technology allowing access to that content, and a business focused on licensing and distributing the content. It was founded by Bruce Blausen in Houston, Texas, in 1991, and is privately held. Background Blausen Medical Communications, Inc. (BMC) is a privately held company founded by Bruce Blausen in Houston, Texas in 1991. BMC created and owns a library of medical and scientific images and animations, and has developed information technology tools allowing access to the library; as well, it licenses and otherwise works to distribute the content. As of this date, BMC's animation library comprised approximately 1,500 animations and over 27,000 two- and three-dimensional images designed for point-of-care patient education, which could be accessed by consumers or professional caregivers (primarily via h ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
TNF Inhibitor
A TNF inhibitor is a pharmaceutical drug that suppresses the physiologic response to tumor necrosis factor (TNF), which is part of the inflammatory response. TNF is involved in autoimmune and immune-mediated disorders such as rheumatoid arthritis, ankylosing spondylitis, inflammatory bowel disease, psoriasis, hidradenitis suppurativa and refractory asthma, so TNF inhibitors may be used in their treatment. The important side effects of TNF inhibitors include lymphomas, infections (especially reactivation of latent tuberculosis), congestive heart failure, demyelinating disease, a lupus-like syndrome, induction of auto-antibodies, injection site reactions, and systemic side effects. The global market for TNF inhibitors in 2008 was $13.5 billion and $22 billion in 2009. Examples Inhibition of TNF effects can be achieved with a monoclonal antibody such as infliximab, adalimumab, certolizumab pegol, and golimumab, or with a circulating receptor fusion protein such as etanercept. Thalid ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
Sulfasalazine
Sulfasalazine, sold under the brand name Azulfidine among others, is a medication used to treat rheumatoid arthritis, ulcerative colitis, and Crohn's disease. It is considered by some to be a first-line treatment in rheumatoid arthritis. It is taken by mouth. Significant side effects occur in about 25% of people. Commonly these include loss of appetite, nausea, headache, and rash. Severe side effects include bone marrow suppression, liver problems, Stevens–Johnson syndrome, and kidney problems. It should not be used in people allergic to aspirin or sulfonamide. Use during pregnancy appears to be safe for the baby. Sulfasalazine is in the disease-modifying antirheumatic drugs (DMARDs) family of medications. It is unclear exactly how it works. One proposed mechanism is the inhibition of prostaglandins, resulting in local anti-inflammatory effects in the colon. The medication is broken down by intestinal bacteria into sulfapyridine and 5-aminosalicylic acid. That which is a ... [...More Info...] [...Related Items...] OR: [Wikipedia] [Google] [Baidu] |
