Acácio is both a masculine Portuguese given name and a surname. Notable people with the name include:

People with the given name

*Acácio Casimiro (born 1949), Portuguese footballer *Acácio (footballer) (born 1959), Brazilian footballer and manager *Acácio da Silva (born 1961), Portuguese cyclist *Acácio de Almeida (born 1938), Portuguese cinematographer *Acácio Mesquita (1909–1945), Portuguese footballer *Acácio Pereira Magro (1932–2018), Portuguese academic, economist and politician *Acácio Rodrigues Alves (1925–2010), Brazilian Roman Catholic bishop

People with the surname

*Adrião Acácio da Silveira Pinto (died 1868), Governor of Macau *Daniel Acácio (born 1977), Brazilian mixed martial artist *Marlon Acácio (born 1982), Mozambican judoka {{DEFAULTSORT:Acacio Portuguese-language surnames Portuguese masculine given names