5F-AB-FUPPYCA (also known as AZ-037) is a
pyrazole
Pyrazole is an organic compound with the formula C3H3N2H. It is a heterocycle characterized by a 5-membered ring of three carbon atoms and two adjacent nitrogen atoms, which are in ortho-substitution. Pyrazole is a weak base, with p''K''b 11.5 ( ...
-based
synthetic cannabinoid that is presumed to be an
agonist of the
CB1 receptor and has been sold online as a
designer drug
A designer drug is a structural or functional analog of a controlled substance that has been designed to mimic the pharmacological effects of the original drug, while avoiding classification as illegal and/or detection in standard drug tests. D ...
. It was first detected by the
EMCDDA as part of a seizure of 540 g white powder in France in February 2015.
The name AZ-037 is also used as a synonym for its structural isomer 5-fluoro-3,5-AB-PFUPPYCA. Thus AZ-037 is being used as a synonym for two different compounds.
5-fluoro-3,5-AB-PFUPPYCA has been detected in synthetic cannabinoid smoke blends in the USA as early as December 30, 2021, along with ADB-BUTINACA,
MDA-19 (BZO-HEXOXIZID) and
MDMB-4en-PINACA.
5-fluoro-AB-PFUPPYCA contains some similar structural elements to other synthetic cannabinoids such as
AB-CHFUPYCA,
JWH-307,
JWH-030,
JWH-147,
AB-PINACA. It may be considered an analog of the traditional
pyrazole
Pyrazole is an organic compound with the formula C3H3N2H. It is a heterocycle characterized by a 5-membered ring of three carbon atoms and two adjacent nitrogen atoms, which are in ortho-substitution. Pyrazole is a weak base, with p''K''b 11.5 ( ...
cannabinoid receptor 1 antagonist
rimonabant
Rimonabant (also known as SR141716; trade names Acomplia, Zimulti) is an anorectic antiobesity drug that was first approved in Europe in 2006 but was withdrawn worldwide in 2008 due to serious psychiatric side effects; it was never approved in t ...
. The pharmacological properties of 5F-AB-FUPPYCA have not been studied.
See also
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AB-CHFUPYCA
*
AM-6545
*
TM-38837
*
Rimonabant
Rimonabant (also known as SR141716; trade names Acomplia, Zimulti) is an anorectic antiobesity drug that was first approved in Europe in 2006 but was withdrawn worldwide in 2008 due to serious psychiatric side effects; it was never approved in t ...
*
JWH-307
*
JWH-147
*
JWH-030
*
AB-FUBINACA
AB-FUBINACA is a drug that acts as a potent agonist for the cannabinoid receptors, with ''K''i values of 0.9 nM at CB1 and 23.2 nM at CB2 and EC50 values of 1.8 nM at CB1 and 3.2 nM at CB2. It was originally developed by P ...
*
ADB-FUBINACA
*
AMB-FUBINACA
AMB-FUBINACA (also known as FUB-AMB and MMB-FUBINACA) is an indazole-based synthetic cannabinoid that is a potent agonist for the cannabinoid receptors, with ''K''i values of 10.04 nM at CB1 and 0.786 nM at CB2 and EC50 values of 0. ...
*
APP-FUBINACA
*
MDA-19
*
FUB-144
FUB-144 (also known as FUB-UR-144) is an indole-based synthetic cannabinoid that is presumed to be a potent agonist of the CB1 receptor and has been sold online as a designer drug. It is an analogue of UR-144 and XLR-11 where the pentyl chain ...
*
FUB-APINACA
FUB-APINACA (also known as AFUBINACA and FUB-AKB48) is an indazole-based synthetic cannabinoid that is presumed to be a potent agonist of the CB1 receptor and has been sold online as a designer drug. It is an analog of APINACA and 5F-APINACA whe ...
*
FUB-JWH-018
*
FDU-PB-22
FDU-PB-22 is a derivative of JWH-018 that is presumed to be a potent agonist of the CB1 receptor, and has been sold online as a designer drug.
Pharmacology
FDU-PB-22 acts as a full agonist with a binding affinity of 1.19nM at CB1 and 2.43nM at ...
*
FUB-PB-22
FUB-PB-22 (QUFUBIC) is an indole-based synthetic cannabinoid that is a potent agonist of the CB1 receptor and has been sold online as a designer drug.
Pharmacology
FUB-PB-22 acts as a full agonist with a binding affinity of 0.386nM at CB1 and ...
*
MDMB-FUBICA
MDMB-FUBICA is an indole-based synthetic cannabinoid that is presumed to be a potent agonist of the CB1 receptor and has been sold online as a designer drug.
It was first detected by the EMCDDA in Sweden in February 2015. It is often sold in e- ...
*
MDMB-FUBINACA
References
Cannabinoids
Designer drugs
Fluoroarenes
Pyrazoles
Pyrazolecarboxamides
Organofluorides
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