20α-Dihydrotrengestone (20α-DHTG), also known as 20α-hydroxytrengestone, as well as 6-chloro-20(''S'')-hydroxy-9β,10α-pregna-1,4,6-trien-3-one, is a
progestin and the major
active metabolite An active metabolite is an active form of a drug after it has been processed by the body.
Metabolites of drugs
An active metabolite results when a drug is metabolized by the body into a modified form which continues to produce effects in the body ...
of
trengestone
Trengestone, sold under the brand names Reteroid, Retroid, and Retrone, is a progestin medication which was formerly used to treat menstrual disorders but is now no longer marketed.http://www.micromedexsolutions.com It is taken oral administrati ...
.
It appears that trengestone is a
prodrug of 20α-DHTG, as it is largely
transformed into this
metabolite when given
orally in humans.
20α-DHTG has
potent progestogenic activity similarly to trengestone.
See also
*
20α-Dihydrodydrogesterone
*
20α-Dihydroprogesterone
20α-Dihydroprogesterone (20α-DHP), also known as 20α-hydroxyprogesterone (20α-OHP), is a naturally occurring, endogenous progestogen. It is a metabolite of progesterone, formed by the 20α-hydroxysteroid dehydrogenases (20α-HSDs) AKR1C1 ...
References
Secondary alcohols
Chloroarenes
Human drug metabolites
Enones
Pregnanes
Progestogens
Conjugated dienes
{{Genito-urinary-drug-stub