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IcyHot
Liniment (from la, linere, meaning "to anoint"), also called embrocation and heat rub, is a medicated topical preparation for application to the skin. Some liniments have viscosity similar to that of water; others are lotion or balm; still others are in transdermal patches, soft solid sticks, and sprays. Liniment usually is rubbed in to the skin, which the active ingredients penetrate. Liniments are typically sold to relieve pain and stiffness, such as from muscle, muscular Pain and nociception, aches and Strain (injury), strains, and arthritis. These are typically formulated from ethanol, alcohol, acetone, or similar quickly evaporating solvents and contain counterirritant aromatic chemical compounds, such as methyl salicilate, benzoin resin, menthol, and capsaicin. They produce a feeling of warmth within the muscle of the area they are applied to, typically acting as rubefacients via a counterirritant effect. Methyl salicylate, which is the analgesic ingredient in some heat ru ...
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Menthol
Menthol is an organic compound, more specifically a monoterpenoid, made synthetically or obtained from the oils of corn mint, peppermint, or other mints. It is a waxy, clear or white crystalline substance, which is solid at room temperature and melts slightly above. The main form of menthol occurring in nature is (−)-menthol, which is assigned the (1''R'',2''S'',5''R'') configuration. Menthol has local anesthetic and counterirritant qualities, and it is widely used to relieve minor throat irritation. Menthol also acts as a weak κ-opioid receptor agonist. Structure Natural menthol exists as one pure stereoisomer, nearly always the (1''R'',2''S'',5''R'') form (bottom left corner of the diagram below). The eight possible stereoisomers are: : In the natural compound, the isopropyl group is in the '' trans'' orientation to both the methyl and hydroxyl groups. Thus, it can be drawn in any of the ways shown: : The (+)- and (−)- enantiomers of menthol are the most stab ...
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Bengay
Bengay, spelled Ben-Gay before 1995, is a topical analgesic heat rub for temporary relief from muscle and joint pain associated with arthritis, bruises, simple backaches, overuse, sprains and strains. Overview Bengay was developed in France by Dr. Jules Bengué () and brought to America in 1898. The name Bengué was Anglicized and commercialized to Ben-Gay (later Bengay). It was originally produced by Pfizer Consumer Healthcare, which was acquired by Johnson & Johnson. The product is advised to be used topically for adults and children 12 years of age and older, and no more than 3 to 4 times daily. The manufacturer recommends storing it between . According to a study published by MIT Technology Review, the exact mechanism of its efficacy is not known. However, evidence indicates that it activates a neuron named TRPM8, which appears to keep minor pain signals in the brain from communicating with the spine. Hazards Bengay and similar products, such as Flexall, Mentholatum, ...
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Herb Knudson's Surgical 11
In general use, herbs are a widely distributed and widespread group of plants, excluding vegetables and other plants consumed for macronutrients, with savory or aromatic properties that are used for flavoring and garnishing food, for medicinal purposes, or for fragrances. Culinary use typically distinguishes herbs from spices. ''Herbs'' generally refers to the leafy green or flowering parts of a plant (either fresh or dried), while ''spices'' are usually dried and produced from other parts of the plant, including seeds, bark, roots and fruits. Herbs have a variety of uses including culinary, medicinal, aromatic and in some cases, spiritual. General usage of the term "herb" differs between culinary herbs and medicinal herbs; in medicinal or spiritual use, any parts of the plant might be considered as "herbs", including leaves, roots, flowers, seeds, root bark, inner bark (and cambium), resin and pericarp. The word "herb" is pronounced in Commonwealth English, but is comm ...
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Methyl Salicylate
Methyl salicylate (oil of wintergreen or wintergreen oil) is an organic compound with the formula C8H8O3. It is the methyl ester of salicylic acid. It is a colorless, viscous liquid with a sweet, fruity odor reminiscent of root beer, but often associatively called "minty", as it is an ingredient in mint candies. It is produced by many species of plants, particularly wintergreens. It is also produced synthetically, used as a fragrance and as a flavoring agent. Biosynthesis and occurrence Methyl salicylate was first isolated (from the plant '' Gaultheria procumbens'') in 1843 by the French chemist Auguste André Thomas Cahours (1813–1891), who identified it as an ester of salicylic acid and methanol. The biosynthesis of methyl salicylate arises via the hydroxylation of benzoic acid by a cytochrome P450 followed by methylation by a methylase enzyme. Methyl salicylate as a plant metabolite Many plants produce methyl salicylate in small quantities. Methyl salicylate levels ar ...
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Pfizer
Pfizer Inc. ( ) is an American multinational pharmaceutical and biotechnology corporation headquartered on 42nd Street in Manhattan, New York City. The company was established in 1849 in New York by two German entrepreneurs, Charles Pfizer (1824–1906) and his cousin Charles F. Erhart (1821–1891). Pfizer develops and produces medicines and vaccines for immunology, oncology, cardiology, endocrinology, and neurology. The company has several blockbuster drugs or products that each generate more than billion in annual revenues. In 2020, 52% of the company's revenues came from the United States, 6% came from each of China and Japan, and 36% came from other countries. Pfizer was a component of the Dow Jones Industrial Average stock market index from 2004 to August 2020. The company ranks 64th on the Fortune 500 and 49th on the Forbes Global 2000. History 1849–1950: Early history Pfizer was founded in 1849 by Charles Pfizer and Charles F. Erhart, two cousins who ha ...
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Jules Bengué
Jules is the French form of the Latin "Julius" (e.g. Jules César, the French name for Julius Caesar). It is the given name of: People with the name * Jules Aarons (1921–2008), American space physicist and photographer *Jules Abadie (1876–1953), French politician and surgeon *Jules Accorsi (born 1937), French football player and manager *Jules Adenis (1823–1900), French playwright and opera librettist *Jules Adler 1865–1952), French painter * Jules Asner (born 1968), American television personality * Jules Aimé Battandier (1848–1922), French botanist * Jules Bernard (born 2000), American basketball player * Jules Bianchi (1989–2015), French Formula One driver * Jules Breton (1827–1906), French Realist painter * Jules-André Brillant (1888–1973), Canadian entrepreneur * Jules Brunet (1838–1911), French Army general * Jules Charles-Roux (1841–1918), French businessman and politician * Jules Dewaquez (1899–1971), French footballer * Jules Marie Alphonse Jacqu ...
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Kasinathuni Nageswara Rao
Kasinadhuni Nageswararao, better known as Nageswara Rao Pantulu, (1 May 1867 – 11 April 1938) was an Indian journalist, nationalist, politician, businessman, and a staunch supporter of Khaddar movement. He participated in the Indian independence movement and in the Indian National Congress party, including Mahatma Gandhi’s civil disobedience movement through salt satyagraha. He was conferred with the title ''Desabandhu'' (Friend of the masses) by the people of Andhra Pradesh. He was a major financier of Congress activities in Andhra and Chennai and is also known for patenting Amrutanjan. He was conferred with the title ''Desoddhaaraka'' (Uplifter of the masses) by the Andhra Mahasabha. In 1935, the Andhra University honoured him with Kalaprapoorna, an honorary doctorate of Literature. Early life Kasinadhuni Nageswararao, popularly known as Nageswararao Pantulu garu, was born on 1 May 1867 in Pesaramilli village, Pamarru mandal in Krishna district of Andhra to a Brahmi ...
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Amrutanjan Healthcare
Amrutanjan Healthcare Limited is an Indian pharmaceutical Public limited company, company headquartered in Chennai, Chennai, Tamil Nadu, India. It was founded by Kasinadhuni Nageswara Rao in Bombay (now Mumbai) in 1893. History Amrutanjan was established as a patent medicine business in Bombay (now Mumbai) in 1893 by Kasinadhuni Nageswara Rao, K. Nageswara Rao Pantulu who was a journalist, social reformer and freedom fighter.#Madras Rediscovered, Madras Rediscovered, Pg 206 The headquarters were shifted to Madras (now Chennai) in 1914. As of 2014, it is headed by Sambhu Prasad, the grandson of Nageshwara Rao. Products Amrutanjan Healthcare's main product is its pain balm. In 2002, Amrutanjan Healthcare launched a series of anti-diabetic medicines called Diakyur. In 2004, the company launched herbal mouth-fresheners under the brand name "Affair". The Amrutanjan group also includes a software company called Amrutanjan Infotech. In July 2001, Amrutanjan Infotech's call-centr ...
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Amrutanjan (balm)
Amrutanjan is an analgesic balm owned by Amrutanjan Healthcare. History Amrutanjan was founded in 1893 by journalist and freedom fighter, Kasinathuni Nageswara Rao. He popularized the balm by distributing it free-of-cost at music concerts. Even today, the words "Bombay" are inscribed along with Amrutanjan on the lid of its most well-known product, the pain balm. In 1936, Amrutanjan became a public limited company with the name Amrutanjan Limited. Medical uses It is used as a balm for: * Headache * Muscular ache * Muscular strain * Arthritis Holding company The brand is owned by the parent Amrutanjan Healthcare Amrutanjan Healthcare Limited is an Indian pharmaceutical Public limited company, company headquartered in Chennai, Chennai, Tamil Nadu, India. It was founded by Kasinadhuni Nageswara Rao in Bombay (now Mumbai) in 1893. History Amrutanjan w .... It is now headed by Sambhu Prasad, the grandson of Nageshwara Rao. References {{reflist External links Official si ...
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Toxin
A toxin is a naturally occurring organic poison produced by metabolic activities of living cells or organisms. Toxins occur especially as a protein or conjugated protein. The term toxin was first used by organic chemist Ludwig Brieger (1849–1919) and is derived from the word toxic. Toxins can be small molecules, peptides, or proteins that are capable of causing disease on contact with or absorption by body tissues interacting with biological macromolecules such as enzymes or cellular receptors. Toxins vary greatly in their toxicity, ranging from usually minor (such as a bee sting) to potentially fatal even at extremely low doses (such as botulinum toxin). Toxins are largely secondary metabolites, which are organic compounds that are not directly involved in an organism's growth, development, or reproduction, instead often aiding it in matters of defense. Terminology Toxins are often distinguished from other chemical agents strictly based on their biological origin. ...
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Chloroform
Chloroform, or trichloromethane, is an organic compound with formula C H Cl3 and a common organic solvent. It is a colorless, strong-smelling, dense liquid produced on a large scale as a precursor to PTFE. It is also a precursor to various refrigerants. It is trihalomethane. It is a powerful anesthetic, euphoriant, anxiolytic, and sedative when inhaled or ingested. Structure The molecule adopts a tetrahedral molecular geometry with C3v symmetry. Natural occurrence The total global flux of chloroform through the environment is approximately tonnes per year, and about 90% of emissions are natural in origin. Many kinds of seaweed produce chloroform, and fungi are believed to produce chloroform in soil. Abiotic processes are also believed to contribute to natural chloroform productions in soils although the mechanism is still unclear. Chloroform volatilizes readily from soil and surface water and undergoes degradation in air to produce phosgene, dichloromethane, formyl ...
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Atropa Belladonna
''Atropa belladonna'', commonly known as belladonna or deadly nightshade, is a toxic perennial herbaceous plant in the nightshade family Solanaceae, which also includes tomatoes, potatoes, and eggplant (aubergine). It is native to Europe, North Africa, and Western Asia. Its distribution extends from Great Britain in the west to western Ukraine and the Iranian province of Gilan in the east. It is also naturalised or introduced in some parts of Canada and the United States. The foliage and berries are extremely toxic when ingested, containing tropane alkaloids. These toxins include atropine, scopolamine, and hyoscyamine, which cause delirium and hallucinations, and are also used as pharmaceutical anticholinergics. Tropane alkaloids are of common occurrence not only in the Old World tribes Hyoscyameae (to which the genus Atropa belongs) and Mandragoreae, but also in the New World tribe Datureae - all of which belong to the subfamily Solanoideae of the plant f ...
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