Tyrosol is an organic compound with the formula . Classified as a phenylethanoid, i.e. a derivative of phenethyl alcohol, It is found in a variety of natural sources. The compound is colorless solid. The principal source in the human diet is olive oil.

Research

As an antioxidant, tyrosol may protect cells against injury due to oxidation ''

in vitro ''In vitro'' (meaning in glass, or ''in the glass'') studies are performed with microorganisms, cells, or biological molecules outside their normal biological context. Colloquially called " test-tube experiments", these studies in biology ...

''. Although it is not as potent as other antioxidants present in olive oil (e.g.,

hydroxytyrosol Hydroxytyrosol is an organic compound with the formula . Classified as a phenylethanoid, i.e. a relative of phenethyl alcohol, Its derivatives are found in a variety of natural sources, notably olive oils and wines. The compound is colorless sol ...

), its higher concentration and good

bioavailability In pharmacology, bioavailability is a subcategory of absorption and is the fraction (%) of an administered drug that reaches the systemic circulation. By definition, when a medication is administered intravenously, its bioavailability is 100%. Ho ...

indicate that it may have an important overall effect. Tyrosol may also be cardioprotective. Trosol-treated animals showed significant increase in the phosphorylation of

Akt Protein kinase B (PKB), also known as Akt, is the collective name of a set of three serine/threonine-specific protein kinases that play key roles in multiple cellular processes such as glucose metabolism, apoptosis, cell proliferation, tran ...

eNOS Enos or Enosh (Hebrew: , Standard ''Enosh'', Tiberian ''ʼĔnôš''; "mortal man”) may refer to: People in religious scripture * Enos (biblical figure), a genealogical figure in the Bible. * The Book of Enos, one of the books that make up the B ...

and

FOXO3a Forkhead box O3, also known as FOXO3 or FOXO3a, is a human protein encoded by the ''FOXO3'' gene. Function FOXO3 belongs to the O subclass of the forkhead family of transcription factors which are characterized by a distinct fork head DNA-bin ...

. In addition, tyrosol also induced the expression of the protein

SIRT1 Sirtuin 1, also known as NAD-dependent deacetylase sirtuin-1, is a protein that in humans is encoded by the SIRT1 gene. SIRT1 stands for sirtuin (silent mating type information regulation 2 homolog) 1 ('' S. cerevisiae''), referring to the fact ...

in the heart after myocardial infarction in a rat MI model. Tyrosol forms esters with a variety of organic acids.

References

{{Antioxidants Phenylethanoids Phenol antioxidants

Research

See also

References