Ytterbium(III) Chloride

Ytterbium(III) chloride ( Yb Cl₃) is an inorganic chemical compound. It reacts with NiCl₂ to form a very effective catalyst for the reductive dehalogenation of aryl halides. It is poisonous if injected, and mildly toxic by ingestion. It is an experimental teratogen, known to irritate the skin and eyes. When heated to decomposition it emits toxic fumes of Cl⁻.

History

The synthesis of YbCl₃ was first reported by Jan Hoogschagen in 1946. It is now a commercially available source of Yb³⁺ ions and therefore of significant chemical interest.

Chemical properties

The valence electron configuration of Yb⁺³ (from YbCl₃) is 4''f''¹³5''s''²5''p''⁶, which has crucial implications for the chemical behaviour of Yb⁺³. Also, the size of Yb⁺³ governs its catalytic behaviour and biological applications. For example, while both Ce⁺³ and Yb⁺³ have a single unpaired ''f'' electron, Ce⁺³ is much larger than Yb⁺³ because lanthanides become much smaller with increasing effective nuclear charge as a consequence of the ''f'' electrons not being as well shielded as ''d'' electrons. This behavior is known as the lanthanide contraction. The small size of Yb⁺³ produces fast catalytic behavior and an atomic radius (0.99 Å) comparable to many biologically important ions.

The gas-phase thermodynamic properties of this chemical are difficult to determine because the chemical can disproportionate to form bCl₆sup>−3 or dimerize. The Yb₂Cl₆ species was detected by electron impact (EI) mass spectrometry as (Yb₂Cl₅⁺). Additional complications in obtaining experimental data arise from the myriad of low-lying ''f''-''d'' and ''f''-''f'' electronic transitions. Despite these issues, the thermodynamic properties of YbCl₃ have been obtained and the C_3V symmetry group has been assigned based upon the four active infrared vibrations.

Preparation

Anhydrous ytterbium(III) chloride can be produced by the ammonium chloride route.

In the first step, ytterbium oxide is heated with ammonium chloride to produce the ammonium salt of the pentachloride:
:Yb₂O₃ + 10NH₄Cl → 2(NH₄)₂YbCl₅ + 6H₂O + 6NH₃
In the second step, the ammonium chloride salt is converted to the trichlorides by heating in a vacuum at 350-400 °C:
:(NH₄)₂YbCl₅ → YbCl₃ + 2HCl + 2NH₃

Reactions

YbCl₃ is a paramagnetic Lewis acid, like many of the lanthanide chlorides. It gives rise to pseudocontact shifted NMR spectra, akin to NMR shift reagents

Applications in biology

Membrane biology has been greatly influenced by YbCl₃, where³⁹K⁺ and²³Na⁺ ion movement is critical in establishing electrochemical gradients. Nerve signaling is a fundamental aspect of life that may be probed with YbCl₃ using NMR
techniques. YbCl₃ may also be used as a calcium ion probe, in a fashion similar
to a sodium ion probe.

YbCl₃ is also used to track digestion in animals. Certain additives to swine feed, such as probiotics, may be added to either solid feed or drinking liquids. YbCl₃ travels
with the solid food and therefore helps determine which food phase is ideal to incorporate the food additive. The YbCl₃ concentration is quantified by inductively coupled plasma mass spectrometry to within 0.0009 μg/mL. YbCl₃ concentration versus time yields the flow rate of solid particulates in the animal's digestion. The animal is not harmed by the YbCl₃ since YbCl₃ is simply excreted in fecal matter and no change in body weight, organ weight, or hematocrit levels has been observed in mice.

The catalytic nature of YbCl₃ also has an application in DNA microarrays, or so called DNA “chips”. YbCl₃ led to a 50–80 fold increase in fluorescein incorporation into target DNA, which could revolutionize infectious disease detection (such as a rapid test for tuberculosis).

References

{{Lanthanide halides

Chlorides
Lanthanide halides
Ytterbium compounds
Catalysts