The yolk sac is a membranous sac attached to an

embryo An embryo is an initial stage of development of a multicellular organism. In organisms that reproduce sexually, embryonic development is the part of the life cycle that begins just after fertilization of the female egg cell by the male spe ...

, formed by cells of the

hypoblast In amniote embryology, the hypoblast, is one of two distinct layers arising from the inner cell mass in the mammalian blastocyst, or from the blastodisc in reptiles and birds. The hypoblast gives rise to the yolk sac, which in turn gives rise to ...

layer of the

bilaminar embryonic disc The bilaminar embryonic disc, bilaminar blastoderm or embryonic disc is the two-layered structure of epiblast and hypoblast, differentiated from the inner cell mass also known as the embryoblast. These two layers of cells lie between two caviti ...

. This is alternatively called the umbilical vesicle by the

Terminologia Embryologica The ''Terminologia Embryologica'' (''TE'') is a standardized list of words used in the description of human embryologic and fetal structures. It was produced by the Federative International Committee on Anatomical Terminology on behalf of the In ...

(TE), though ''yolk sac'' is far more widely used. In humans, the yolk sac is important in early embryonic blood supply, and much of it is incorporated into the primordial gut during the fourth week of

embryonic development An embryo is an initial stage of development of a multicellular organism. In organisms that reproduce sexually, embryonic development is the part of the life cycle that begins just after fertilization of the female egg cell by the male sperm ...

In humans

Ultrasound of embryo at 5 weeks, colored

The yolk sac is the first element seen within the

gestational sac The gestational sac is the large cavity of fluid surrounding the embryo. During early embryogenesis it consists of the extraembryonic coelom, also called the chorionic cavity. The gestational sac is normally contained within the uterus. It is the o ...

during

pregnancy Pregnancy is the time during which one or more offspring develops ( gestates) inside a woman's uterus (womb). A multiple pregnancy involves more than one offspring, such as with twins. Pregnancy usually occurs by sexual intercourse, but ca ...

, usually at 3 days

gestation Gestation is the period of development during the carrying of an embryo, and later fetus, inside viviparous animals (the embryo develops within the parent). It is typical for mammals, but also occurs for some non-mammals. Mammals during pregna ...

. The yolk sac is situated on the front (

ventral Standard anatomical terms of location are used to unambiguously describe the anatomy of animals, including humans. The terms, typically derived from Latin or Greek language, Greek roots, describe something in its standard anatomical position. Th ...

) part of the

; it is lined by extra-embryonic

endoderm Endoderm is the innermost of the three primary germ layers in the very early embryo. The other two layers are the ectoderm (outside layer) and mesoderm (middle layer). Cells migrating inward along the archenteron form the inner layer of the gast ...

, outside of which is a layer of extra-embryonic

mesenchyme Mesenchyme () is a type of loosely organized animal embryonic connective tissue of undifferentiated cells that give rise to most tissues, such as skin, blood or bone. The interactions between mesenchyme and epithelium help to form nearly every o ...

, derived from the epiblast. Blood is conveyed to the wall of the yolk sac by the primitive

aorta The aorta ( ) is the main and largest artery in the human body, originating from the left ventricle of the heart and extending down to the abdomen, where it splits into two smaller arteries (the common iliac arteries). The aorta distributes ...

and after circulating through a wide-meshed capillary plexus, is returned by the

vitelline veins The vitelline veins are veins that drain blood from the yolk sac and the gut tube during gestation. Path They run upward at first in front, and subsequently on either side of the intestinal canal. They unite on the ventral aspect of the canal. ...

to the tubular heart of the embryo. This constitutes the vitelline circulation, which in humans serves as a location of

haematopoiesis Haematopoiesis (, from Greek , 'blood' and 'to make'; also hematopoiesis in American English; sometimes also h(a)emopoiesis) is the formation of blood cellular components. All cellular blood components are derived from haematopoietic stem cells. ...

. Before the placenta is formed and can take over, the yolk sac provides nutrition and gas exchange between the mother and the developing embryo. At the end of the fourth week, the yolk sac presents the appearance of a small pear-shaped opening (traditionally called the ''umbilical vesicle''), into the digestive tube by a long narrow tube, the

vitelline duct In the human embryo, the vitelline duct, also known as the vitellointestinal duct, the yolk stalk, the omphaloenteric duct, or the omphalomesenteric duct, is a long narrow tube that joins the yolk sac to the midgut lumen of the developing fetus. ...

. Rarely, the yolk sac can be seen in the afterbirth as a small, somewhat oval-shaped body whose diameter varies from 1 mm to 5 mm; it is situated between the

amnion The amnion is a membrane that closely covers the human and various other embryos when first formed. It fills with amniotic fluid, which causes the amnion to expand and become the amniotic sac that provides a protective environment for the develo ...

and the

chorion The chorion is the outermost fetal membrane around the embryo in mammals, birds and reptiles (amniotes). It develops from an outer fold on the surface of the yolk sac, which lies outside the zona pellucida (in mammals), known as the vitelline ...

and may lie on or at a varying distance from the

placenta The placenta is a temporary embryonic and later fetal organ that begins developing from the blastocyst shortly after implantation. It plays critical roles in facilitating nutrient, gas and waste exchange between the physically separate mater ...

. There is no clinical significance to a residual external yolk sac. File:Gray24.svg, Diagram showing earliest observed stage of human ovum.
1 - Amniotic cavity
2 - Yolk-sac
3 - Chorion File:Gray25.svg, Diagram illustrating early formation of allantois and differentiation of body-stalk.
1 Amniotic cavity
2 Body-stalk
3 Allantois
4 Yolk-sac
5 Chorion File:Gray26.svg, Diagram showing later stage of allantoic development with commencing constriction of the yolk-sac.
1 Heart
2 Amniotic cavity
3 Embryo
4 Body-stalk
5 Placental villi
6 Allantois
7 Yolk-sac
8 Chorion File:Gray28.svg, Diagram illustrating a later stage in the development of the umbilical cord.
1 Placental villi
2 Yolk-sac
3 Umbilical cord
4 Allantois
5 Heart
6 Digestive tube
7 Embryo
8 Amniotic cavity As a rule the duct undergoes complete obliteration by the 20th week as most of the yolk sac is incorporated into the developing gastrointestinal tract, but in about two percent of cases its proximal part persists as a diverticulum from the small intestine,

Meckel's diverticulum A Meckel's diverticulum, a true congenital diverticulum, is a slight bulge in the small intestine present at birth and a vestigial remnant of the omphalomesenteric duct (also called the vitelline duct or yolk stalk). It is the most common malformat ...

, which is situated about 60 cm proximal to the

ileocecal valve The ileocecal valve (ileal papilla, ileocaecal valve, Tulp's valve, Tulpius valve, Bauhin's valve, ileocecal eminence, valve of Varolius or colic valve) is a sphincter muscle valve that separates the small intestine and the large intestine. Its c ...

, and may be attached by a fibrous cord to the abdominal wall at the umbilicus. Sometimes a narrowing of the lumen of the

ileum The ileum () is the final section of the small intestine in most higher vertebrates, including mammals, reptiles, and birds. In fish, the divisions of the small intestine are not as clear and the terms posterior intestine or distal intestine ma ...

is seen opposite the site of attachment of the duct.

Histogenesis

The yolk sac starts forming during the second week of the embryonic development, at the same time as the shaping of the amniotic sac. The

starts proliferating laterally and descending. In the meantime

Heuser's membrane Heuser's membrane (or the exocoelomic membrane) is a short lived combination of hypoblast cells and extracellular matrix In biology, the extracellular matrix (ECM), also called intercellular matrix, is a three-dimensional network consisting of ...

, located on the opposite pole of the developing vesicle, starts its upward proliferation and meets the hypoblast.

Modifications

*Primary yolk sac: it is the vesicle which develops in the second week, its floor is represented by

and its ceiling by the

. It is also known as the exocoelomic cavity. *Secondary yolk sac: this structure is formed when the extraembryonic

mesoderm The mesoderm is the middle layer of the three germ layers that develops during gastrulation in the very early development of the embryo of most animals. The outer layer is the ectoderm, and the inner layer is the endoderm.Langman's Medical E ...

separates to form the

extraembryonic coelom The gestational sac is the large cavity of fluid surrounding the embryo. During early embryogenesis it consists of the extraembryonic coelom, also called the chorionic cavity. The gestational sac is normally contained within the uterus. It is the o ...

; cells from the mesoderm pinch off an area of the yolk sac, and what remains is the secondary yolk sac. *The final yolk sac: during the fourth week of development, during

organogenesis Organogenesis is the phase of embryonic development that starts at the end of gastrulation and continues until birth. During organogenesis, the three germ layers formed from gastrulation (the ectoderm, endoderm, and mesoderm) form the internal orga ...

, part of the yolk sac is surrounded by

and incorporated into the embryo as the gut. The remaining part of the yolk sac is the final yolk sac.

Additional images

File:Gray14.png, Surface view of embryo of

Hylobates concolor The black crested gibbon (''Nomascus concolor'') is a Critically Endangered species of gibbon found in China, Laos, and northern Vietnam, with four subspecies. Taxonomy The taxonomy of the species is confused. Previously grouped in the genus ...

(a gibbon). File:Gray17.png, Human embryo—length, 2 mm. Dorsal view, with the amnion laid open. X 30. File:Gray20.png, Dorsum of human embryo, 2.11 mm in length. File:Gray21.png, Section through the embryo. File:Gray30.png, Fetus of about eight weeks, enclosed in the amnion. Magnified a little over two diameters. File:Gray31.png, Model of human embryo 1.3 mm long. File:Gray32.png, Section through ovum imbedded in the uterine decidua File:Gray977.png, Human embryo about fifteen days old. Brain and heart represented from right side. Digestive tube and yolk sac in median section.

References

{{DEFAULTSORT:Yolk Sac Embryology of cardiovascular system

In humans

Histogenesis

Modifications

Additional images

See also

References