Wolf W. Zuelzer
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Wolf William Zuelzer (May 24, 1909 – March 20, 1987) was a German-American
pediatric Pediatrics ( also spelled ''paediatrics'' or ''pædiatrics'') is the branch of medicine that involves the medical care of infants, children, adolescents, and young adults. In the United Kingdom, paediatrics covers many of their youth until the ...
pathologist Pathology is the study of the causal, causes and effects of disease or injury. The word ''pathology'' also refers to the study of disease in general, incorporating a wide range of biology research fields and medical practices. However, when us ...
. He worked at the
Children's Hospital of Michigan Children's Hospital of Michigan (CHM) is a for-profit, pediatric acute care hospital located in Detroit, Michigan. The hospital has 227 beds and is affiliated with both the Wayne State University School of Medicine and the Michigan State Universit ...
for 35 years, where he oversaw a large amount of pediatric research, particularly in the field of
hematology Hematology ( always spelled haematology in British English) is the branch of medicine concerned with the study of the cause, prognosis, treatment, and prevention of diseases related to blood. It involves treating diseases that affect the produc ...
. He received the
John Howland Award The John Howland Award is the highest honor bestowed by the American Pediatric Society (APS). Named in honor of John Howland (1873–1926), the award, with its accompanying medal, is presented annually by the American Pediatric Society for "dist ...
in 1985.


Early life

Zuelzer was born in Berlin in 1909 to
George George may refer to: People * George (given name) * George (surname) * George (singer), American-Canadian singer George Nozuka, known by the mononym George * George Washington, First President of the United States * George W. Bush, 43rd Presiden ...
and Edith Zuelzer. His father was a physician who pioneered anti-diabetic therapies and came from a strongly medical family. His mother, meanwhile, was a pianist whose parents were also accomplished musicians. After graduating from gymnasium he studied philosophy and
Romance languages The Romance languages, sometimes referred to as Latin languages or Neo-Latin languages, are the various modern languages that evolved from Vulgar Latin. They are the only extant subgroup of the Italic languages in the Indo-European language fam ...
at
Heidelberg University } Heidelberg University, officially the Ruprecht Karl University of Heidelberg, (german: Ruprecht-Karls-Universität Heidelberg; la, Universitas Ruperto Carola Heidelbergensis) is a public research university in Heidelberg, Baden-Württemberg, ...
. In 1928, he was selected to undertake a fellowship at the
University of Paris , image_name = Coat of arms of the University of Paris.svg , image_size = 150px , caption = Coat of Arms , latin_name = Universitas magistrorum et scholarium Parisiensis , motto = ''Hic et ubique terrarum'' (Latin) , mottoeng = Here and a ...
, where he became fluent in French and was introduced to French literature. He returned to Germany in 1929 and began a doctorate in French literature, but six months before he was due to complete his PhD, he decided to study medicine instead. He completed his preclinical studies at the
University of Bonn The Rhenish Friedrich Wilhelm University of Bonn (german: Rheinische Friedrich-Wilhelms-Universität Bonn) is a public research university located in Bonn, North Rhine-Westphalia, Germany. It was founded in its present form as the ( en, Rhine U ...
and moved to Berlin in 1932 to finish his clinical training. When Hitler came to power, however, Zuelzer decided to leave Nazi Germany to finish his medical studies at the
German University in Prague ) , image_name = Carolinum_Logo.svg , image_size = 200px , established = , type = Public, Ancient , budget = 8.9 billion CZK , rector = Milena Králíčková , faculty = 4,057 , administrative_staff = 4,026 , students = 51,438 , undergr ...
, graduating in 1935.


Career

Zuelzer migrated to the United States in August 1935. After working briefly at the Cambridge City Hospital in
Cambridge, Massachusetts Cambridge ( ) is a city in Middlesex County, Massachusetts, United States. As part of the Boston metropolitan area, the cities population of the 2020 U.S. census was 118,403, making it the fourth most populous city in the state, behind Boston, ...
, he was appointed a house officer in the pediatric department of the
Massachusetts General Hospital Massachusetts General Hospital (Mass General or MGH) is the original and largest teaching hospital of Harvard Medical School located in the West End neighborhood of Boston, Massachusetts. It is the third oldest general hospital in the United Stat ...
. In 1938, he began volunteering at the
Boston Children's Hospital Boston Children's Hospital formerly known as Children's Hospital Boston until 2012 is a nationally ranked, freestanding acute care children's hospital located in Boston, Massachusetts, adjacent both to its teaching affiliate, Harvard Medical Scho ...
with
Sidney Farber Sidney Farber (September 30, 1903 – March 30, 1973) was an American pediatric pathologist. He is regarded as the father of modern chemotherapy for his work using folic acid antagonists to combat leukemia, which led to the development of other c ...
, the country's first pediatric pathologist. He was a resident pathologist at
Children's Memorial Hospital Ann & Robert H. Lurie Children's Hospital of Chicago, formerly Children's Memorial Hospital and commonly known as Lurie Children's, is a nationally ranked pediatric acute care children's hospital located in Chicago, Illinois. The hospital has 3 ...
in Chicago for two-and-a-half years before moving to Detroit to take up a position that was created specifically for him, as a professor of pediatric research at
Wayne State University Wayne State University (WSU) is a public research university in Detroit, Michigan. It is Michigan's third-largest university. Founded in 1868, Wayne State consists of 13 schools and colleges offering approximately 350 programs to nearly 25,000 ...
and director of the laboratories at the
Children's Hospital of Michigan Children's Hospital of Michigan (CHM) is a for-profit, pediatric acute care hospital located in Detroit, Michigan. The hospital has 227 beds and is affiliated with both the Wayne State University School of Medicine and the Michigan State Universit ...
. He was a temporary chairman of the hospital's pediatric department in 1946 and was appointed director of the Child Research Center of Michigan in 1955. He worked at the Child Research Center and Children's Hospital of Michigan for 35 years; during that time, he oversaw research in numerous fields of pediatrics and published over 250 research articles. Zuelzer's research was particularly influential in the field of
hematology Hematology ( always spelled haematology in British English) is the branch of medicine concerned with the study of the cause, prognosis, treatment, and prevention of diseases related to blood. It involves treating diseases that affect the produc ...
, particularly regarding
hemoglobinopathies Hemoglobinopathy is the medical term for a group of inherited blood disorders and diseases that primarily affect red blood cells. They are single-gene disorders and, in most cases, they are inherited as autosomal co-dominant traits. There are t ...
such as
thalassemia Thalassemias are inherited blood disorders characterized by decreased hemoglobin production. Symptoms depend on the type and can vary from none to severe. Often there is mild to severe anemia (low red blood cells or hemoglobin). Anemia can result ...
s and
sickle cell anemia Sickle cell disease (SCD) is a group of blood disorders typically inherited from a person's parents. The most common type is known as sickle cell anaemia. It results in an abnormality in the oxygen-carrying protein haemoglobin found in red blo ...
. He and Gene Kaplan were the first to describe
ABO hemolytic disease of the newborn In ABO hemolytic disease of the newborn (also known as ABO HDN) maternal IgG antibodies with specificity for the ABO blood group system pass through the placenta to the fetal circulation where they can cause hemolysis of fetal red blood cells wh ...
, and Zuelzer published one of the first studies to show that
acute leukemia Acute leukemia or acute leukaemia is a family of serious medical conditions relating to an original diagnosis of leukemia. In most cases, these can be classified according to the lineage, myeloid or lymphoid, of the malignant cells that grow uncon ...
s in childhood could be cured by
chemotherapy Chemotherapy (often abbreviated to chemo and sometimes CTX or CTx) is a type of cancer treatment that uses one or more anti-cancer drugs (chemotherapeutic agents or alkylating agents) as part of a standardized chemotherapy regimen. Chemotherap ...
. He received the 1948
E. Mead Johnson Award The E. Mead Johnson Award, given by the Society for Pediatric Research, was established in 1939 to honor clinical and laboratory research achievements in pediatrics. The awards are funded by Mead Johnson, Mead Johnson Nutritionals, a subsidiary of ...
for his research into
megaloblastic anemia Megaloblastic anemia is a type of macrocytic anemia. An anemia is a red blood cell defect that can lead to an undersupply of oxygen. Megaloblastic anemia results from inhibition of DNA replication, DNA synthesis during red blood cell production. ...
in infants. In 1975, Zuelzer resigned from the Children's Hospital of Michigan and moved to
Silver Spring, Maryland Silver Spring is a census-designated place (CDP) in southeastern Montgomery County, Maryland, United States, near Washington, D.C. Although officially unincorporated, in practice it is an edge city, with a population of 81,015 at the 2020 censu ...
, to take up a position at the
National Heart, Lung, and Blood Institute The National Heart, Lung, and Blood Institute (NHLBI) is the third largest Institute of the National Institutes of Health, located in Bethesda, Maryland, United States. It is tasked with allocating about $3.6 billion in FY 2020 in tax revenue to ...
as the institute's associate director and the director of blood resources. In his later career, he also published numerous non-medical works, including a biography of the German physiologist
Georg Friedrich Nicolai Georg Friedrich Nicolai (born Lewinstein; 6 February 1874 – 8 October 1964) was a German physiologist. Biography He was born in 1874 in Berlin. He studied at the University of Berlin, and later practiced medicine at the Charité in Berlin. He a ...
, numerous articles in the German intellectual magazine ''
Merkur Merkur (, '' Mercury'') is a defunct automobile brand that was marketed by the Lincoln- Mercury division of Ford Motor Company from 1985 to 1989. Drawing its name from the German word for Mercury, Merkur was targeted at buyers of European execut ...
'', and a historical account of the
Watergate scandal The Watergate scandal was a major political scandal in the United States involving the administration of President Richard Nixon from 1972 to 1974 that led to Nixon's resignation. The scandal stemmed from the Nixon administration's continual ...
. In 1985 he was awarded the
John Howland Award The John Howland Award is the highest honor bestowed by the American Pediatric Society (APS). Named in honor of John Howland (1873–1926), the award, with its accompanying medal, is presented annually by the American Pediatric Society for "dist ...
, the highest honor given by the
American Pediatric Society The American Pediatric Society (APS) is the first pediatric society established in North America. Created in 1888, the APS pursues a vision of an engaged, inclusive, and impactful community of pediatric thought leaders. The APS mission is to sha ...
.


Death

Zuelzer died of
leukemia Leukemia ( also spelled leukaemia and pronounced ) is a group of blood cancers that usually begin in the bone marrow and result in high numbers of abnormal blood cells. These blood cells are not fully developed and are called ''blasts'' or ' ...
on March 20, 1987, aged 77, at
George Washington University Hospital The George Washington University Hospital is a for-profit hospital, located in Washington, D.C. in the United States. It is affiliated with the George Washington University School of Medicine and Health Sciences. The current facility opened on ...
, in
Washington, D.C. ) , image_skyline = , image_caption = Clockwise from top left: the Washington Monument and Lincoln Memorial on the National Mall, United States Capitol, Logan Circle, Jefferson Memorial, White House, Adams Morgan, ...


Notes


References

{{DEFAULTSORT:Zuelzer, Wolf W. 1909 births 1987 deaths American pathologists American pediatricians German pathologists German pediatricians 20th-century American physicians Physicians from Berlin People from Silver Spring, Maryland Heidelberg University alumni University of Bonn alumni Charles University alumni Wayne State University faculty Deaths from cancer in Washington, D.C. German emigrants to the United States