Vincent's Powders
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Vincent Chemical Company was an Australian business noted for manufacture of a popular
compound analgesic Compound analgesics are those with multiple active ingredients; they include many of the stronger prescription analgesics. Active ingredients that have been commonly used in compound analgesics include: * aspirin or ibuprofen * caffeine * codeine ...
"Vincent's APC"


History

Dr. Harry John Clayton (ca.1887 – 31 October 1928) of Macquarie Street and medical superintendent of the
Royal Prince Alfred Hospital The Royal Prince Alfred Hospital (abbreviated RPAH or RPA) is a major public teaching hospital in Sydney, Australia, located on Missenden Road in Camperdown. It is a teaching hospital of the Central Clinical School of the Sydney Medical School ...
, Sydney, took the headache remedy then in general use, composed of
phenacetin Phenacetin (acetophenetidin, ''N''-(4-ethoxyphenyl)acetamide) is a pain-relieving and fever-reducing drug, which was widely used following its introduction in 1887. It was withdrawn from medicinal use as dangerous from the 1970s (e.g., withdrawn ...
and
caffeine Caffeine is a central nervous system (CNS) stimulant of the methylxanthine class. It is mainly used recreationally as a cognitive enhancer, increasing alertness and attentional performance. Caffeine acts by blocking binding of adenosine t ...
, and by experimenting with the addition of
aspirin Aspirin, also known as acetylsalicylic acid (ASA), is a nonsteroidal anti-inflammatory drug (NSAID) used to reduce pain, fever, and/or inflammation, and as an antithrombotic. Specific inflammatory conditions which aspirin is used to treat inc ...
, arrived at what became the standard formulation known as A.P.C. powder, or in the Royal Prince Alfred Hospital Pharmacopæia for 1918 as ''Pulvis Analgesicus''. In 1919, at the insistence of his wife, Clayton founded a partnership consisting of Mrs Clayton, E. W. Wills, C. K. Probert (dispenser at the Royal Prince Alfred Hospital), and J. A. Vincent (1890 – 12 June 1933), who had been assistant dispenser at the hospital, and was at that time a pharmacist with a business at
Five Dock Five Dock is a suburb in the Inner West of Sydney, in the state of New South Wales, Australia. Five Dock is located 10 kilometres west of the Sydney central business district, in the local government area of the City of Canada Bay. Location Fi ...
. Clayton chose the names "Vincent Chemical Company" and "Vincent's APC" to distance himself, as a practicing physician, from any commercial product. During the pneumonic influenza epidemic April to July 1919, he offered many of his customers packages of the compound as A.P.C. powder, which may have been labeled "Vincent's A.P.C." The partnership was incorporated on 11 September 1919 with paid-up capital of £200; £50 from each of the partners; later doubled to total £400. Vincent made up the compound, coloured pink, in premises adjacent to his chemist's shop, as 12 envelopes of powder in a box, or as 24 tablets in a small bottle, and labeled as "pain remedy". Printed instructions for use, supplied ''gratis'' by Clayton, were included with each package, bearing the company's trademark "Vincent's APC". The business did not thrive initially, at least in part due to insufficient advertising, and in May 1921 Vincent sold his share of the business (as did Wills) to Probert and Mrs. Clayton, and left for America to train as a dentist, selling his chemist's shop and passing the fledgling manufacturing business to wholesale druggist William Delany. After several months of supplying Clayton and Probert with the product, he was brought into the partnership. In July 1923 the business was re-formed with three owners, Dora Lauraine Clayton, Minnie Probert and Harriett Delany, with joint managers Mr. Probert and Mr. Delany, and in that year the company first showed a profit. They registered their trademark "Vincent's APC" on 21 July 1930, and invested heavily in advertising: £2575 in 1931, £3367 in 1932 and £4703 in 1933, in which year they made a profit of £18,400. The trademark design changed little from this time: "VINCENT'S" in white lettering on a blue rectangle, with "A•P•C" in white on a blue semicircle attached directly below, and "GENUINE (PINK)" in blue on a yellow semicircle attached above.


Return of Dr. Vincent

In 1924, Vincent returned to Sydney, having qualified as Doctor of Dental Surgery, and opened a practice in Haberfield. He was still on friendly terms with Probert, and intimated to him that he would like to rejoin the partnership, and on 8 March 1926 wrote to them with an offer, intimating that he had other products with which they could diversify, to which Delany replied on 10 March, stating that none of the shareholders was interested in his proposal, concluding ominously: "As you mention that you are desirous of putting certain new lines of chemical preparations on the Australian market, I have to remind you that perhaps the most valuable asset of the Vincent Chemical Company in this field is now its trademark ... and that it could not permit this asset to be challenged or imperilled." In September 1932, Dr. Vincent, who had invented an analgesic toothpaste, founded a company Vincent's Products, Ltd., with a nominal capital of £1000, to manufacture and market this product. Dr. Vincent was originally appointed managing director, but died shortly after, and his widow Hilda A. Vincent (née Mills) was appointed in his place. In 1934 Vincent Chemical Co. sued Vincent's Products, Ltd. for infringement of their trademark. The court upheld the complaint and issued a limited injunction against the defendant from using that name in circumstances which might lead customers to believe the companies were associated, and awarded costs against Vincent's Products, Ltd. Around 1936, Vincent's APC was first also marketed in "pocket-size" rectangular cans containing 24 tablets.


Advertising slogans

*1928: Take genuine Vincent's powders *1938: For safety's sake take Vincent's APC *1941: The same today as in 1917 ... Take Vincent's with confidence. *1950s: Take Vincent's with confidence for quick three-way relie
Vincent's radio jingles (YouTube)
*late 1970s - "It's your day, don't share it with a headache! Vincents helps when you need help with pain." (sung)


Phenacetin dropped

At some time before 1972 Vincent Chemical Co. replaced the
phenacetin Phenacetin (acetophenetidin, ''N''-(4-ethoxyphenyl)acetamide) is a pain-relieving and fever-reducing drug, which was widely used following its introduction in 1887. It was withdrawn from medicinal use as dangerous from the 1970s (e.g., withdrawn ...
in the formulation of its powders and tablets with
salicylamide Salicylamide (''o''-hydroxybenzamide or amide of salicyl) is a non-prescription drug with analgesic and antipyretic properties. Its medicinal uses are similar to those of aspirin. Salicylamide is used in combination with both aspirin and caffe ...
. Compound analgesics were banned in Australia in 1979 due to
analgesic nephropathy Analgesic nephropathy is injury to the kidneys caused by analgesic medications such as aspirin, bucetin, phenacetin, and paracetamol. The term usually refers to damage induced by excessive use of combinations of these medications, especially co ...
. Phenacetin, a pain-relieving and fever-reducing drug, was banned by the FDA in the US in 1983, due to its adverse effects, which include kidney damage (as shown by Dr. Priscilla Kincaid-Smith) and cancer. It was replaced in many other medications by its metabolite,
paracetamol Paracetamol, also known as acetaminophen, is a medication used to treat fever and mild to moderate pain. Common brand names include Tylenol and Panadol. At a standard dose, paracetamol only slightly decreases body temperature; it is inferior ...
.


See also

*
Bex (compound analgesic) Bex was a strong compound analgesic which was popular in Australia for much of the 20th century. It came in the form of APC (aspirin– phenacetin–caffeine) tablets or powder, containing 42% aspirin and 42% phenacetin plus caffeine. B ...


References

{{DEFAULTSORT:Vincent Chemical Co Pharmaceutical companies of Australia Manufacturing companies based in Sydney Pharmaceutical companies established in 1919 Chemical companies established in 1919