The Vandenbergh effect is a phenomenon reported by J.G. Vandenbergh ''et al.'' in 1975, in which an early induction of the first

estrous cycle The estrous cycle (, originally ) is the set of recurring physiological changes that are induced by reproductive hormones in most mammalian therian females. Estrous cycles start after sexual maturity in females and are interrupted by anestrous p ...

in prepubertal female mice occurs as a result of exposure to the

pheromone A pheromone () is a secreted or excreted chemical factor that triggers a social response in members of the same species. Pheromones are chemicals capable of acting like hormones outside the body of the secreting individual, to affect the behavio ...

-laden urine of a sexually mature (dominant) male mouse. Physiologically, the exposure to male urine induces the release of

GnRH Gonadotropin-releasing hormone (GnRH) is a releasing hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is a tropic peptide hormone synthesized and released f ...

, which provokes the first estrus. The Vandenbergh effect has also been seen with exposure to adult female mice. When an immature female mouse is exposed to the urine of mature female mouse, estrus is delayed in the prepubertal female. In this situation, GnRH is inhibited and therefore delays puberty in the juvenile female mouse.''An Introduction to Behavioral Endocrinology'', 3rd edition.

Randy J. Nelson Randy J. Nelson is an American neuroscientist who holds the Hazel Ruby McQuain Chair for Neurological Research and the founding chair of the Department of Neuroscience at the West Virginia University School of Medicine. Much of his research has fo ...

. Sinauer Associates, 2005. The Vandenbergh effect is caused by pheromones found in a male's urine. The male does not have to be present for this effect to take place; the urine alone is sufficient. These pheromones are detected by the vomeronasal organ in the septum of the female's nose. This occurs because the female body will only take the step to begin puberty if there are available mates around. She will not waste energy on puberty if there is no possibility of finding a mate. In addition to GnRH,

exogenous In a variety of contexts, exogeny or exogeneity () is the fact of an action or object originating externally. It contrasts with endogeneity or endogeny, the fact of being influenced within a system. Economics In an economic model, an exogeno ...

estradiol Estradiol (E2), also spelled oestradiol, is an estrogen steroid hormone and the major female sex hormone. It is involved in the regulation of the estrous and menstrual female reproductive cycles. Estradiol is responsible for the development of f ...

has recently implicated as having a role in the Vandenbergh effect. Utilizing tritium-labeled estradiol implanted in male mice, researchers have been able to trace the pathways the estradiol takes once transmitted to a female. The estradiol was found in a multitude of regions within the females and appeared to enter her circulation nasally and through the skin. Their findings suggested that some aspects of the Vandenbergh effect as well as the

Bruce effect The Bruce effect, or pregnancy block, is the tendency for female rodents to terminate their pregnancies following exposure to the scent of an unfamiliar male. The effect was first noted in 1959 by Hilda M. Bruce, and has primarily been studied i ...

may be related to exogenous estradiol from males. Additional studies have looked into the validity of estradiol's role in the Vandenbergh effect by means of exogenous estradiol placed in

castrated Castration is any action, surgical, chemical, or otherwise, by which an individual loses use of the testicles: the male gonad. Surgical castration is bilateral orchiectomy (excision of both testicles), while chemical castration uses pharmaceut ...

rats. Castrated males were injected with either a

control Control may refer to: Basic meanings Economics and business * Control (management), an element of management * Control, an element of management accounting * Comptroller (or controller), a senior financial officer in an organization * Controllin ...

(oil) or estradiol in the oil vehicle. As expected, urinary

androgens An androgen (from Greek ''andr-'', the stem of the word meaning "man") is any natural or synthetic steroid hormone that regulates the development and maintenance of male characteristics in vertebrates by binding to androgen receptors. This inc ...

in the castrated males were below normal levels. Additionally, castration by itself rid the males of the capacity to induce growth of the

uterus The uterus (from Latin ''uterus'', plural ''uteri'') or womb () is the organ in the reproductive system of most female mammals, including humans that accommodates the embryonic and fetal development of one or more embryos until birth. The uter ...

in prepubescent females or to disrupt implantation of the

blastocyst The blastocyst is a structure formed in the early embryonic development of mammals. It possesses an inner cell mass (ICM) also known as the ''embryoblast'' which subsequently forms the embryo, and an outer layer of trophoblast cells called the t ...

in females that had previously been inseminated. However, when resupplied with estradiol, the castrated males regained the ability to induce uterine growth or halt blastocyst implantation. These studies further support estradiol's role in mediating the Vandenbergh effect (as well as the Bruce effect).

See also

References

Further reading