Whitten Effect
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Whitten Effect
The Whitten effect is stimulation, by male pheromones, of synchronous estrus in a female population. Social signals, or social stimuli, have an effect on reproduction in all mammals. For certain female mice, the pheromones contained in the urine of male mice can be such stimuli, inducing synchronous estrus.Ochiogu, Izuchukwu S., Chike F. Oguejiofor, and Ambrose N. Nwagbo. "Males' Non-Enhancement of Bruce and Whitten Effects in Female Mice – Mus Musculus." Animal Research International 6 (2009): 1077-081. When the pheromones contained in the urine of male mice stimulate synchronous estrus in a population of female mice, it is known as the Whitten effect. This is a phenomenon observed by Wesley K. Whitten (1956, 1966, 1968), whereby male mouse pheromone-laden urine synchronizes the estrus cycle "among unisexually grouped females," and is an example of male-to-female pheromonal effects in mice, similar to the Bruce effect.Jemilio, Bozena, Scott Harvey, and Milos Novotny. "Promo ...
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Estrus
The estrous cycle (, originally ) is the set of recurring physiological changes that are induced by reproductive hormones in most mammalian therian females. Estrous cycles start after sexual maturity in females and are interrupted by anestrous phases, otherwise known as "rest" phases, or by Pregnancy, pregnancies. Typically, estrous cycles repeat until death. These cycles are widely variable in duration and frequency depending on the species.Bronson, F. H., 1989. Mammalian Reproductive Biology. University of Chicago Press, Chicago, IL, USA. Some animals may display bloody vaginal discharge, often mistaken for menstruation. Many mammals used in commercial agriculture, such as cattle and sheep, may have their estrous cycles artificially controlled with hormonal medications for optimum productivity. The male equivalent, seen primarily in ruminants, is called Rut (mammalian reproduction), rut. Differences from the menstrual cycle Mammals share the same reproductive system, includ ...
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Mammal
Mammals () are a group of vertebrate animals constituting the class Mammalia (), characterized by the presence of mammary glands which in females produce milk for feeding (nursing) their young, a neocortex (a region of the brain), fur or hair, and three middle ear bones. These characteristics distinguish them from reptiles (including birds) from which they diverged in the Carboniferous, over 300 million years ago. Around 6,400 extant species of mammals have been described divided into 29 orders. The largest orders, in terms of number of species, are the rodents, bats, and Eulipotyphla (hedgehogs, moles, shrews, and others). The next three are the Primates (including humans, apes, monkeys, and others), the Artiodactyla ( cetaceans and even-toed ungulates), and the Carnivora (cats, dogs, seals, and others). In terms of cladistics, which reflects evolutionary history, mammals are the only living members of the Synapsida (synapsids); this clade, together with Saur ...
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Pheromone
A pheromone () is a secreted or excreted chemical factor that triggers a social response in members of the same species. Pheromones are chemicals capable of acting like hormones outside the body of the secreting individual, to affect the behavior of the receiving individuals. There are ''alarm signal, alarm pheromones'', ''food trail pheromones'', ''sex pheromones'', and many others that affect behavior or physiology. Pheromones are used by many organisms, from basic unicellular prokaryotes to complex multicellular eukaryotes. Their use among insects has been particularly well documented. In addition, some vertebrates, plants and ciliates communicate by using pheromones. The ecological functions and evolution of pheromones are a major topic of research in the field of chemical ecology. Background The portmanteau word "pheromone" was coined by Peter Karlson and Martin Lüscher in 1959, based on the Greek φερω ''pheroo'' ('I carry') and ὁρμων ''hormon'' ('stimulating'). P ...
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Synchronization
Synchronization is the coordination of events to operate a system in unison. For example, the conductor of an orchestra keeps the orchestra synchronized or ''in time''. Systems that operate with all parts in synchrony are said to be synchronous or ''in sync''—and those that are not are '' asynchronous''. Today, time synchronization can occur between systems around the world through satellite navigation signals and other time and frequency transfer techniques. Navigation and railways Time-keeping and synchronization of clocks is a critical problem in long-distance ocean navigation. Before radio navigation and satellite-based navigation, navigators required accurate time in conjunction with astronomical observations to determine how far east or west their vessel traveled. The invention of an accurate marine chronometer revolutionized marine navigation. By the end of the 19th century, important ports provided time signals in the form of a signal gun, flag, or dropping time ...
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Wesley Kingston Whitten
Wesley Kingston Whitten (1 August 1918 – 24 May 2010) was a professor of reproductive biology at the Australian National University and later director of the Jackson Laboratory, Bar Harbor, Maine, United States. He was educated at the University of Sydney receiving a BVSc with honors in 1939; a BSc in 1941; and DSc in 1962. He was a Walter and Eliza Hall Fellow in Veterinary Science from 1940 to 1941. He served in the Australian Army Veterinary Corps and was an Australian Army Service Corps Captain from 1941 to 1945. He was research officer in Commonwealth Scientific and Industrial Research Organisation (CSIRO) from 1946 to 1949. He was director of animal breeding and fellow in the John Curtin School of Medical Research, Australian National University from 1950 to 1961. He was assistant director of the National Biological Standards Laboratory, Canberra, Australia from 1961 to 1966. He was staff scientist at the Jackson Laboratory, Bar Harbor, Maine, USA from 1966 to 1969, became ...
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Bruce Effect
The Bruce effect, or pregnancy block, is the tendency for female rodents to terminate their pregnancies following exposure to the scent of an unfamiliar male. The effect was first noted in 1959 by Hilda M. Bruce, and has primarily been studied in laboratory mice (''Mus musculus''). In mice, pregnancy can only be terminated prior to embryo implantation, but other species will interrupt even a late-term pregnancy. The Bruce effect is also observed in deer-mice, meadow voles, collared lemmings, and it has also been proposed, but not confirmed, in other non-rodent species such as lions and geladas. Discovery In an experiment published in 1959, zoologist Hilda Bruce of the National Institute for Medical Research in London housed pregnant mice with male mice that were not the father of the carried embryo. As a result, the rate of miscarriages increased, followed by mating with the new male. No increased rate of miscarriages occurred when pregnant mice were paired with castrated or ju ...
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Lee–Boot Effect
The Lee–Boot effect is a phenomenon concerning the suppression or prolongation of oestrous cycles of mature female mice (and other rodents), when females are housed in groups and isolated from males. It is caused by the effects of an estrogen-dependent pheromone, possibly 2,5-dimethylpyrazine, which is released via the urine and acts on the vomeronasal organ of recipients. This pheromone lowers the concentration of luteinizing hormone and elevates prolactin levels, synchronising or stopping the recipient's cycle. This effect goes some way to explain why spontaneous pseudopregnancy can occur in mice. The same response is invoked from isolated females when brought into contact with urine-soaked bedding from other females' cages. The adrenal glands are required for production of the urine pheromone which is responsible for this effect. See also * Menstrual synchrony * Whitten effect The Whitten effect is stimulation, by male pheromones, of synchronous estrus in a female population. ...
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McClintock Effect
Menstrual synchrony, also called the McClintock effect, or the Wellesley effect, is a contested process whereby women who begin living together in close proximity would experience their menstrual cycle onsets (the onset of menstruation or menses) becoming more synchronized together in time than when previously living apart. "For example, the distribution of onsets of seven female lifeguards was scattered at the beginning of the summer, but after 3 months spent together, the onset of all seven cycles fell within a 4-day period." Martha McClintock's 1971 paper, published in ''Nature'', says that menstrual cycle synchronization happens when the menstrual cycle onsets of two or more women become closer together in time than they were several months earlier. After the initial studies, several papers were published reporting methodological flaws in studies reporting menstrual synchrony including McClintock's study. In addition, other studies were published that failed to find synchron ...
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Vandenbergh Effect
The Vandenbergh effect is a phenomenon reported by J.G. Vandenbergh ''et al.'' in 1975, in which an early induction of the first estrous cycle in prepubertal female mice occurs as a result of exposure to the pheromone-laden urine of a sexually mature (dominant) male mouse. Physiologically, the exposure to male urine induces the release of GnRH, which provokes the first estrus. The Vandenbergh effect has also been seen with exposure to adult female mice. When an immature female mouse is exposed to the urine of mature female mouse, estrus is delayed in the prepubertal female. In this situation, GnRH is inhibited and therefore delays puberty in the juvenile female mouse.''An Introduction to Behavioral Endocrinology'', 3rd edition. Randy J. Nelson. Sinauer Associates, 2005. The Vandenbergh effect is caused by pheromones found in a male's urine. The male does not have to be present for this effect to take place; the urine alone is sufficient. These pheromones are detected by the vomeron ...
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Ethology
Ethology is the scientific study of animal behaviour, usually with a focus on behaviour under natural conditions, and viewing behaviour as an evolutionarily adaptive trait. Behaviourism as a term also describes the scientific and objective study of animal behaviour, usually referring to measured responses to stimuli or to trained behavioural responses in a laboratory context, without a particular emphasis on evolutionary adaptivity. Throughout history, different naturalists have studied aspects of animal behaviour. Ethology has its scientific roots in the work of Charles Darwin and of American and German ornithologists of the late 19th and early 20th century, including Charles O. Whitman, Oskar Heinroth, and Wallace Craig. The modern discipline of ethology is generally considered to have begun during the 1930s with the work of Dutch biologist Nikolaas Tinbergen and Austrian biologists Konrad Lorenz and Karl von Frisch, the three recipients of the 1973 Nobel Prize in Phys ...
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