Ultrasonography of deep vein thrombosis of the femoral vein -annotated

Ultrasonography Ultrasound is sound waves with frequencies higher than the upper audible limit of human hearing. Ultrasound is not different from "normal" (audible) sound in its physical properties, except that humans cannot hear it. This limit varies fr ...

in suspected

deep vein thrombosis Deep vein thrombosis (DVT) is a type of venous thrombosis involving the formation of a blood clot in a deep vein, most commonly in the legs or pelvis. A minority of DVTs occur in the arms. Symptoms can include pain, swelling, redness, and enla ...

focuses primarily on the

femoral vein In the human body, the femoral vein is a blood vessel that accompanies the femoral artery in the femoral sheath. It begins at the adductor hiatus (an opening in the adductor magnus muscle) as the continuation of the popliteal vein. It ends at th ...

and the

popliteal vein The popliteal vein is a vein of the lower limb. It is formed from the anterior tibial vein and the posterior tibial vein. It travels medial to the popliteal artery, and becomes the femoral vein. It drains blood from the leg. It can be assessed ...

, because thrombi in these veins are associated with the greatest risk of harmful

pulmonary embolism Pulmonary embolism (PE) is a blockage of an pulmonary artery, artery in the lungs by a substance that has moved from elsewhere in the body through the bloodstream (embolism). Symptoms of a PE may include dyspnea, shortness of breath, chest pain p ...

Medical uses

The risk of deep vein thrombosis can be estimated by Wells score. Lower limbs venous ultrasonography is also indicated in cases of suspected

where a

CT pulmonary angiogram A CT pulmonary angiogram (CTPA) is a medical diagnostic test that employs computed tomography (CT) angiography to obtain an image of the pulmonary arteries. Its main use is to diagnose pulmonary embolism (PE). It is a preferred choice of imaging i ...

is negative but a high clinical suspicion of pulmonary embolism remains. It may identify a deep vein thrombosis in up to 50% of people with pulmonary embolism.

Knee In humans and other primates, the knee joins the thigh with the leg and consists of two joints: one between the femur and tibia (tibiofemoral joint), and one between the femur and patella (patellofemoral joint). It is the largest joint in the hu ...

hip replacement Hip replacement is a surgical procedure in which the hip joint is replaced by a prosthetic implant, that is, a hip prosthesis. Hip replacement surgery can be performed as a total replacement or a hemi (half) replacement. Such joint replacement o ...

are, by themselves, not indications to perform the procedure., which cites * Serial follow-up the ultrasound exam is not necessary after an initially complete, normal study in individuals with DVT symptoms who have suspected

and nondiagnostic

ventilation/perfusion scan A ventilation/perfusion lung scan, also called a V/Q lung scan, or ventilation/perfusion scintigraphy, is a type of medical imaging using scintigraphy and medical isotopes to evaluate the circulation of air and blood within a patient's lungs, in o ...

s .

Technique and findings

Unlike

arterial An artery (plural arteries) () is a blood vessel in humans and most animals that takes blood away from the heart to one or more parts of the body (tissues, lungs, brain etc.). Most arteries carry oxygenated blood; the two exceptions are the pul ...

ultrasonography, venous ultrasonography is carried out with the probe in a transversal position, (

perpendicular In elementary geometry, two geometric objects are perpendicular if they intersect at a right angle (90 degrees or π/2 radians). The condition of perpendicularity may be represented graphically using the ''perpendicular symbol'', ⟂. It can ...

to the vein axis), displaying cross-sections of the veins. All collateral veins are better detected this way, including

perforator vein Perforator veins are so called because they perforate the deep fascia of muscles, to connect the superficial veins to the deep veins where they drain. Perforator veins play an essential role in maintaining normal blood draining. They have valves ...

s, but of most importance is the detection of venous

thrombosis Thrombosis (from Ancient Greek "clotting") is the formation of a blood clot inside a blood vessel, obstructing the flow of blood through the circulatory system. When a blood vessel (a vein or an artery) is injured, the body uses platelets (thro ...

. The most reliable sign of thrombosis (even when a good image and color is present) is the absence of compressibility - A vein cannot be compressed when the blood is in a solid state, as with a

thrombus A thrombus (plural thrombi), colloquially called a blood clot, is the final product of the blood coagulation step in hemostasis. There are two components to a thrombus: aggregated platelets and red blood cells that form a plug, and a mesh of c ...

, in the same way that a rubber pipe cannot be compressed if the water inside is frozen. However, if the probe is parallel to the vein axis, when the examiner compresses it, the probe can slide to the right or to the left giving a

false negative A false positive is an error in binary classification in which a test result incorrectly indicates the presence of a condition (such as a disease when the disease is not present), while a false negative is the opposite error, where the test result ...

for thrombosis as the probe has moved away and the vein will not then be evident. Nevertheless, when the examiner needs to show the head thrombus in a printout, the probe will be presented parallel to the vein axis.

Echogenicity

A very recently formed thrombus is not very solid, it will have a low

echogenicity Echogenicity (misspelled sometimes as echogenecity) or echogeneity is the ability to bounce an echo, e.g. return the signal in ultrasound examinations. In other words, echogenicity is higher when the surface bouncing the sound echo reflects increa ...

, and will be seen as a black area in the gray-scale image and will be hardly visible. When the examiner uses color, the imaging is not much improved. A thrombus may not be evident in the scan. Also a vein lumen may show echoes without the presence of a thrombus. The location of the thrombus and its detail will inform of the seriousness of the condition. In a

(DVT), or in a

superficial vein thrombosis Superficial vein thrombosis (SVT) is a blood clot formed in a superficial vein, a vein near the surface of the body. Usually there is thrombophlebitis, which is an inflammatory reaction around a thrombosed vein, presenting as a painful induration ...

where the thrombus is floating, an emergency situation will be indicated. If the thrombus is near to the sapheno-femoral junction there will be a high risk of a

occurring.

Compression

The inability to compress the vein is one of the more reliable indications of venous thrombosis. There is a simplified technique called "compression ultrasonography" which can be used for quick DVT diagnosis, mainly for the

common femoral vein In the human body, the femoral vein is a blood vessel that accompanies the femoral artery in the femoral sheath. It begins at the adductor hiatus (an opening in the adductor magnus muscle) as the continuation of the popliteal vein. It ends at th ...

and the

. It is very useful in an emergency situation and is performed just by vein compression using transducer pressure. Compression ultrasonography has both high

sensitivity and specificity ''Sensitivity'' and ''specificity'' mathematically describe the accuracy of a test which reports the presence or absence of a condition. Individuals for which the condition is satisfied are considered "positive" and those for which it is not are ...

for detecting DVT in symptomatic patients. Results are not reliable when the patient is symptomless and must be checked carefully. For example, in high risk post-operative patients, mainly after orthopedic surgery where there is already lower limb pain and edema following surgery, thrombi can be localized in the calf veins and often these are not completely occlusive. In this situation a complete examination is mandatory.

Doppler

Doppler ultrasonography Doppler ultrasonography is medical ultrasonography that employs the Doppler effect to perform imaging of the movement of tissues and body fluids (usually blood), and their relative velocity to the probe. By calculating the frequency shift of ...

of venous blood flow that correlates with respiration can be diagnostic of the absence of deep vein thrombosis.

References