Ubiquitin-conjugating enzyme E2 D2 is a

protein Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...

that in humans is encoded by the ''UBE2D2''

gene In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...

Function

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme functions in the ubiquitination of the tumor-suppressor protein p53, which is induced by an E3 ubiquitin-protein ligase. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.

Interactions

UBE2D2 has been shown to

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Baculoviral IAP repeat-containing protein 3 Baculoviral IAP repeat-containing protein3 (also known as cIAP2) is a protein that in humans is encoded by the ''BIRC3'' gene. cIAP2 is a member of the inhibitor of apoptosis family that inhibit apoptosis by interfering with the activation of cas ...

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NEDD4 E3 ubiquitin-protein ligase NEDD4, also known as neural precursor cell expressed developmentally down-regulated protein 4 (whence "NEDD4") is an enzyme that is, in humans, encoded by the ''NEDD4'' gene. NEDD4 is an E3 ubiquitin ligase enzyme, that ...

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PJA1 E3 ubiquitin-protein ligase Praja1 is an enzyme that in humans is encoded by the ''PJA1'' gene. Interactions PJA1 has been shown to interact with UBE2D2 Ubiquitin-conjugating enzyme E2 D2 is a protein that in humans is encoded by the ''UBE2D ...

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PJA2 E3 ubiquitin-protein ligase Praja2 is an enzyme that in humans is encoded by the ''PJA2'' gene. Interactions PJA2 has been shown to interact with UBE2D2 Ubiquitin-conjugating enzyme E2 D2 is a protein that in humans is encoded by the ''UBE2D2 ...

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UBE3A Ubiquitin-protein ligase E3A (UBE3A) also known as E6AP ubiquitin-protein ligase (E6AP) is an enzyme that in humans is encoded by the ''UBE3A'' gene. This enzyme is involved in targeting proteins for degradation within cells. Protein degradation ...

Function

Interactions

References

Further reading