ABC transporter transmembrane domain is the main transmembrane structural unit of

ATP-binding cassette transporter The ATP synthase, ATP-binding cassette transporters (ABC transporters) are a transport system superfamily that is one of the largest and possibly one of the oldest gene family, gene families. It is represented in all extant taxon, extant Phylum ...

proteins, consisting of six alpha helixes that traverse the plasma membrane. Many members of the ABC transporter family () have two such regions. This family appears to correspond to ABC1 by TCDB classification.

Subfamilies

* Sulphate ABC transporter permease protein 2 * Phosphate transport system permease protein 2 * Phosphonate uptake transporter * Nitrate transport permease * NifC-like ABC-type porter * Phosphate ABC transporter, permease protein PstC * Molybdate ABC transporter, permease protein * Nickel ABC transporter, permease subunit NikB * Nickel ABC transporter, permease subunit NikC * Ectoine/hydroxyectoine ABC transporter, permease protein EhuD * Ectoine/hydroxyectoine ABC transporter, permease protein EhuC

Human proteins containing this domain

ABCB1 P-glycoprotein 1 (permeability glycoprotein, abbreviated as P-gp or Pgp) also known as multidrug resistance protein 1 (MDR1) or ATP-binding cassette sub-family B member 1 (ABCB1) or cluster of differentiation 243 (CD243) is an important protein ...

; ABCB10; ABCB11;

ABCB4 The ATP-binding cassette 4 gene encodes the Multidrug resistance protein 3. ABCB4 is associated with progressive familial intrahepatic cholestasis type 3 and intrahepatic cholestasis of pregnancy. The membrane-associated protein encoded by this ...

;

ABCB5 ATP-binding cassette sub-family B member 5 also known as P-glycoprotein ABCB5 is a plasma membrane-spanning protein that in humans is encoded by the ''ABCB5'' gene. ABCB5 is an ABC transporter and P-glycoprotein family member principally express ...

;

ABCB6 ATP-binding cassette super-family B member 6, mitochondrial is a protein that in humans is encoded by the ''ABCB6'' gene. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporte ...

;

ABCB7 ATP-binding cassette sub-family B member 7, mitochondrial is a protein that in humans is encoded by the ''ABCB7'' gene. Function The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) ...

;

ABCB8 ATP-binding cassette sub-family B member 8, mitochondrial is a protein that in humans is encoded by the ''ABCB8'' gene. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters ...

;

ABCB9 ATP-binding cassette sub-family B member 9 is a protein that in humans is encoded by the ''ABCB9'' gene. The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins ...

;

ABCC1 Multidrug resistance-associated protein 1 (MRP1) is a protein that in humans is encoded by the ''ABCC1'' gene. Function The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins t ...

;

ABCC10 Multidrug resistance-associated protein 7 is a protein that in humans is encoded by the ''ABCC10'' gene. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various mo ...

;

ABCC11 ATP-binding cassette transporter sub-family C member 11, also MRP8 (''Multidrug Resistance-Related Protein 8'') is a membrane transporter that exports certain molecules from inside a cell. It is a protein that in humans is encoded by gene ''ABCC11 ...

;

ABCC12 Multidrug resistance-associated protein 9 is a protein that in humans is encoded by the ''ABCC12'' gene. Function This gene is a member of the superfamily of ATP-binding cassette (ABC) transporters and the encoded protein contains two ATP-bin ...

; ABCC13;

ABCC2 Multidrug resistance-associated protein 2 (MRP2) also called canalicular multispecific organic anion transporter 1 (cMOAT) or ATP-binding cassette sub-family C member 2 (ABCC2) is a protein that in humans is encoded by the ''ABCC2'' gene. Functi ...

; ABCC3;

ABCC4 ATP-binding cassette sub-family C member 4 (ABCC4), also known as the multidrug resistance-associated protein 4 (MRP4) or multi-specific organic anion transporter B (MOAT-B), is a protein that in humans is encoded by the ''ABCC4'' gene. ABCC4 act ...

; ABCC5; ABCC6;

ABCC8 ATP-binding cassette transporter sub-family C member 8 is a protein that in humans is encoded by the ''ABCC8'' gene. ''ABCC8'' orthologs have been identified in all mammals for which complete genome data are available. The protein encoded by this ...

; ABCC9;

CFTR Cystic fibrosis transmembrane conductance regulator (CFTR) is a membrane protein and anion channel in vertebrates that is encoded by the ''CFTR'' gene. Geneticist Lap-Chee Tsui and his team identified the CFTR gene in 1989 as the gene linked wi ...

;

TAP1 Transporter associated with antigen processing 1 (TAP1) is a protein that in humans is encoded by the ''TAP1'' gene. A member of the ATP-binding cassette transporter family, it is also known as ABCB2. Function The membrane-associated protein en ...

;

TAP2 TAP2 is a gene in humans that encodes the protein Antigen peptide transporter 2. Function The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport v ...

; TAPL;

References

ATP-binding cassette transporters Protein domains Protein families {{membrane-protein-stub