Theodor Karl Gustav von Leber (29 February 1840 – 17 April 1917) was a German ophthalmologist from

Karlsruhe Karlsruhe ( , , ; South Franconian: ''Kallsruh'') is the third-largest city of the German state (''Land'') of Baden-Württemberg after its capital of Stuttgart and Mannheim, and the 22nd-largest city in the nation, with 308,436 inhabitants. ...

Leber was a student of

Hermann von Helmholtz Hermann Ludwig Ferdinand von Helmholtz (31 August 1821 – 8 September 1894) was a German physicist and physician who made significant contributions in several scientific fields, particularly hydrodynamic stability. The Helmholtz Associatio ...

(1821-1894) in

Heidelberg Heidelberg (; Palatine German language, Palatine German: ''Heidlberg'') is a city in the States of Germany, German state of Baden-Württemberg, situated on the river Neckar in south-west Germany. As of the 2016 census, its population was 159,914 ...

, where he received his doctorate in 1862. He remained in

as an assistant to Hermann Jakob Knapp (1832-1911) at the Heidelberg eye clinic, afterwards studying

physiology Physiology (; ) is the scientific study of functions and mechanisms in a living system. As a sub-discipline of biology, physiology focuses on how organisms, organ systems, individual organs, cells, and biomolecules carry out the chemical ...

under

Carl Ludwig Carl Friedrich Wilhelm Ludwig (; 29 December 1816 – 23 April 1895) was a German physician and physiologist. His work as both a researcher and teacher had a major influence on the understanding, methods and apparatus used in almost all branches ...

(1816-1895) in

Vienna en, Viennese , iso_code = AT-9 , registration_plate = W , postal_code_type = Postal code , postal_code = , timezone = CET , utc_offset = +1 , timezone_DST ...

. From 1867 until 1870 he was an assistant to ophthalmologist

Albrecht von Graefe Albrecht von Graefe may refer to: * Albrecht von Graefe (ophthalmologist) (1828-1870), Prussian opthalmologist * Albrecht von Graefe (politician) Albrecht von Graefe (1 January 1868 – 18 April 1933) was a German landowner and right-wing ...

(1828-1870) in

Berlin Berlin ( , ) is the capital and List of cities in Germany by population, largest city of Germany by both area and population. Its 3.7 million inhabitants make it the European Union's List of cities in the European Union by population within ci ...

. In 1871, he became director of the university eye clinic in

Göttingen Göttingen (, , ; nds, Chöttingen) is a university city in Lower Saxony, central Germany, the capital of the eponymous district. The River Leine runs through it. At the end of 2019, the population was 118,911. General information The ori ...

, and from 1890 to 1910 was director of the eye clinic in Heidelberg. Leber was the first to describe what is now known as

Leber's congenital amaurosis Leber congenital amaurosis (LCA) is a rare inherited eye disease that appears at birth or in the first few months of life. It affects about 1 in 40,000 newborns. LCA was first described by Theodor Leber in the 19th century. It should not be co ...

in 1869 and

Leber's hereditary optic neuropathy Leber's hereditary optic neuropathy (LHON) is a mitochondrially inherited (transmitted from mother to offspring) degeneration of retinal ganglion cells (RGCs) and their axons that leads to an acute or subacute loss of central vision; it predomin ...

in 1871.Man PY, Turnbull DM, Chinnery PF

"Leber hereditary optic neuropathy." ''J Med Genet.'' 2002 Mar;39(3):162-9. . An anatomical structure called "Leber's plexus" is named after him, which is a small venous

plexus In neuroanatomy, a plexus (from the Latin term for "braid") is a branching network of vessels or nerves. The vessels may be blood vessels (veins, capillaries) or lymphatic vessels. The nerves are typically axons outside the central nervous syste ...

in the eye located between

Schlemm's canal Schlemm's canal is a circular lymphatic-like vessel in the eye. It collects aqueous humor from the anterior chamber and delivers it into the episcleral blood vessels. Canaloplasty may be used to widen it. Structure Schlemm's canal is an endot ...

(named after German anatomist Friedrich Schlemm) and Fontana's spaces (named after Italian physicist

Felice Fontana Abbé Gasparo Ferdinando Felice Fontana (15 April 1730 – 9 March 1805) was an Italian polymath who contributed to experimental studies in physiology, toxicology, and physics. As a physicist he discovered the water gas shift reaction in 1780. He ...

). A scholarship given by the German Ophthalmological Society is named after Leber, and is called the ''Theodor-Leber-Stipendium zur Förderung der pharmakologischen und pharmakophysiologischen Forschung in der Augenheilkunde''.

References

1840 births 1917 deaths German ophthalmologists Physicians from Karlsruhe People from the Grand Duchy of Baden Heidelberg University alumni Heidelberg University faculty Humboldt University of Berlin alumni University of Göttingen faculty {{Germany-med-bio-stub