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Theodor Christian Brun Frølich (29 September 1870 – 14 August 1947) was a Norwegian physician and Professor of Pediatrics at the
University of Oslo The University of Oslo (; ) is a public university, public research university located in Oslo, Norway. It is the List of oldest universities in continuous operation#Europe, oldest university in Norway. Originally named the Royal Frederick Univ ...
. In 1938 he was nominated for the
Nobel Prize in Physiology or Medicine The Nobel Prize in Physiology or Medicine () is awarded yearly by the Nobel Assembly at the Karolinska Institute for outstanding discoveries in physiology or medicine. The Nobel Prize is not a single prize, but five separate prizes that, acco ...
for his pioneering contributions to the study of the treatment of
Scurvy Scurvy is a deficiency disease (state of malnutrition) resulting from a lack of vitamin C (ascorbic acid). Early symptoms of deficiency include weakness, fatigue, and sore arms and legs. Without treatment, anemia, decreased red blood cells, gum d ...
and to the development of
Vitamin C Vitamin C (also known as ascorbic acid and ascorbate) is a water-soluble vitamin found in citrus and other fruits, berries and vegetables. It is also a generic prescription medication and in some countries is sold as a non-prescription di ...
.


Biography

Theodor Frølich was born in Christiania (now Oslo), Norway. He was the son of ''Hofmarskalk'' (Lord Steward of the Household)
Theodor Christian Brun Frølich Theodor is a masculine given name. It is a German form of Theodore. It is also a variant of Teodor. List of people with the given name Theodor * Theodor Adorno, (1903–1969), German philosopher * Theodor Aman, Romanian painter * Theodor Bluege ...
(1834–1904) and Bodil Christina (Stina) Grønn (1834–1901). In 1897 he married (Clara Constance Rosalie) Aimée Thaulow Knutsen (1873–1948). Their son was the fencer Jens Frølich (1914–1938), who competed in the individual and team
foil Foil may refer to: Materials * Foil (metal), a quite thin sheet of metal, usually manufactured with a rolling mill machine * Metal leaf, a very thin sheet of decorative metal * Aluminium foil, a type of wrapping for food * Tin foil, metal foil ma ...
events at the
1936 Summer Olympics The 1936 Summer Olympics (), officially the Games of the XI Olympiad () and officially branded as Berlin 1936, were an international multi-sport event held from 1 to 16 August 1936 in Berlin, then capital of Nazi Germany. Berlin won the bid to ...
. Their grandsons were
jazz musician This is a list of jazz musicians by instrument based on existing articles on Wikipedia. Do not enter names that lack articles. Do not enter names that lack sources. Accordion * Kamil Běhounek (1916–1983) * Luciano Biondini (born 1971) * Asm ...
s Theodor Christian Frølich «Totti» Bergh (1935–2012) and his brother ''Johs. Bergh'' (1932–2001).


Early career

After
examen artium Examen artium was the name of the academic certification conferred in Denmark and Norway, qualifying the student for admission to university studies. Examen artium was originally introduced as the entrance exam of the University of Copenhagen in 1 ...
from Gjertsen's Skole (1888) Frølich studied medicine at the University of Oslo and gained the ''cand.med'' degree in 1895. He was a general practitioner in
Larvik Larvik () is a List of municipalities of Norway, municipality in Vestfold county, Norway. It is located in the Traditional districts of Norway, traditional district of Vestfold. The administrative centre of the municipality is the Larvik (town) ...
and
Sandefjord Spa Sandefjord Spa (, often shortened to Kurbadet), was a spa in Sandefjord, Norway, established by Heinrich Arnold Thaulow in 1837. The main building from 1899 is one of the largest wooden buildings in Norway and in the Nordic countries overall. Kurb ...
and returned to Kristiania in 1896 as chief physician at
Rikshospitalet Oslo University Hospital, Rikshospitalet, is one of the four main campuses of Oslo University Hospital in Oslo, Norway. It was an independent hospital, ''Rigshospitalet'', later spelled ''Rikshospitalet'' ("The National Hospital"), from 1826 to 20 ...
, the departement of
pediatrics Pediatrics (American English) also spelled paediatrics (British English), is the branch of medicine that involves the medical care of infants, children, Adolescence, adolescents, and young adults. In the United Kingdom, pediatrics covers many o ...
. He did research on
diabetes Diabetes mellitus, commonly known as diabetes, is a group of common endocrine diseases characterized by sustained high blood sugar levels. Diabetes is due to either the pancreas not producing enough of the hormone insulin, or the cells of th ...
in children, resulting in his doctorate (dr.med) in 1903. Frølich then joined professor Axel Holst (1860–1931) at the University Institute of Hygiene to study
scurvy Scurvy is a deficiency disease (state of malnutrition) resulting from a lack of vitamin C (ascorbic acid). Early symptoms of deficiency include weakness, fatigue, and sore arms and legs. Without treatment, anemia, decreased red blood cells, gum d ...
, suspected of being a nutritional deficiency among fishermen, then called ''shipboard beri-beri''. Holst and Frølich established an animal model that allowed systematic study of factors that led to the ship-related dietary disease, as well as the preventive value of different substances. They discovered that scurvy occurred in guinea pigs when fed solely with various types of grain, either whole or baked into bread, and these symptoms were prevented when the diet was supplemented with known
antiscorbutic Scurvy is a deficiency disease (state of malnutrition) resulting from a lack of vitamin C (ascorbic acid). Early symptoms of deficiency include weakness, fatigue, and sore arms and legs. Without treatment, decreased red blood cells, gum disease, ...
s like fresh cabbage or lemon juice. Frølich published his results in 1910 and 1912 and identified
vitamin C Vitamin C (also known as ascorbic acid and ascorbate) is a water-soluble vitamin found in citrus and other fruits, berries and vegetables. It is also a generic prescription medication and in some countries is sold as a non-prescription di ...
before the essential idea of ''vitamins'' had been introduced, maybe the single most important piece of vitamin C research. In 1920 Frølich was appointed Professor of pediatrics at the Oslo University. He engaged in research on
tuberculosis Tuberculosis (TB), also known colloquially as the "white death", or historically as consumption, is a contagious disease usually caused by ''Mycobacterium tuberculosis'' (MTB) bacteria. Tuberculosis generally affects the lungs, but it can al ...
, became president of ''Nasjonalforeningen mot tuberkulosen'' (the National Society Against Tuberculosis), and initiated the preventive
Tuberculin skin test The Mantoux test or Mendel–Mantoux test (also known as the Mantoux screening test, tuberculin sensitivity test, Pirquet test, or PPD test for purified protein derivative) is a tool for screening for tuberculosis (TB) and for tuberculosis dia ...
for school children. In Norway Frølich was also renowned for ''Dr. Frølichs Cough Syrup'', a sweetened extract of
Carapichea ipecacuanha ''Carapichea ipecacuanha'' is a species of flowering plant in the family Rubiaceae. It is native to Costa Rica, Nicaragua, Panama, Colombia, and Brazil. Its common name, ipecacuanha (), is derived from the Tupi (). The plant has been discusse ...
.


Honors

* 1918–1920 Det norske medicinske Selskab, president * 1923–1924 Den norske legeforening, president * 1924 Det Norske Videnskaps-Akademi, member * 1935 Det Kongelige Norske Videnskabers Selskab, member * 1928–1937 Nationalforeningen mot tuberkulosen, president * 1931–1937 Oslo helseråd (Municipal Health Council of Oslo), member * 1931
Legion of Honour The National Order of the Legion of Honour ( ), formerly the Imperial Order of the Legion of Honour (), is the highest and most prestigious French national order of merit, both military and Civil society, civil. Currently consisting of five cl ...
, France, officer * 1934
Order of St. Olav The Royal Norwegian Order of Saint Olav (; or ''Sanct Olafs Orden'', the old Norwegian name) is a Norwegian order of chivalry instituted by King Oscar I on 21 August 1847. It is named after King Olav II, known to posterity as St. Olav. Just be ...
, Norway, knight * 1935
Gunnerus Medal The Gunnerus Medal () is a medal awarded by the learned society Royal Norwegian Society of Sciences and Letters. It was inaugurated in 1927, and named after Johan Ernst Gunnerus, founder of the learned society. Members of the learned society are e ...
, of Det Kongelige Norske Videnskabers Selskab. * Honorary member of Norsk pediatrisk selskap (The Norwegian Pediatric Society) * 1933 Doctor honoris causa from
Karolinska Institutet The Karolinska Institute (KI; ; sometimes known as the (Royal) Caroline Institute in English) is a research-led medical university in Solna within the Stockholm urban area of Sweden and one of the foremost medical research institutes globally. ...
, Stockholm


Books

* T. Frølich: ''Studier over Diabetes mellitus i barnealderen af Theodor Frølich.'' 1903 * T. Frølich: ''Experimentelle Untersuchungen über den infantilen Skorbut.'' In: ''Z. Hyg. Infektionskrankh.'' Band 72, 1912, S. 155–182. * T. Frølich: ''Pædiatri: en veiledning under studiet av den første barnealders sygdommer.'' 1924 * T. Frølich: ''Nordisk Lærebog i Pædiatri'' Munksgaard, 1945, 892 S. * T. Frølich: ''Pædiatri.'' Steen, 1924


References

{{DEFAULTSORT:Frolich, Theodor 1870 births 1948 deaths University of Oslo alumni Academic staff of the University of Oslo Oslo University Hospital people Norwegian medical researchers Members of the Norwegian Academy of Science and Letters