TRPML (transient receptor potential cation channel, mucolipin subfamily) comprises a group of three evolutionarily related proteins that belongs to the large family of
transient receptor potential
Transient receptor potential channels (TRP channels) are a group of ion channels located mostly on the plasma membrane of numerous animal cell types. Most of these are grouped into two broad groups: Group 1 includes TRPC ( "C" for canonical), TR ...
ion channels. The three proteins
TRPML1,
TRPML2 and
TRPML3 are encoded by the mucolipin-1 (''
MCOLN1''), mucolipin-2 (''
MCOLN2'') and mucolipin-3 (''
MCOLN3'') genes, respectively.
The three members of the TRPML ("ML" for mucolipin) sub-family are not extremely well characterized.
TRPML1 is known to be localized in late
endosome
Endosomes are a collection of intracellular sorting organelles in eukaryotic cells. They are parts of endocytic membrane transport pathway originating from the trans Golgi network. Molecules or ligands internalized from the plasma membrane can ...
s.
This subunit also contains a lipase domain between its S1 and S2 segments. While the function of this domain is unknown it has been proposed that it is involved in channel regulation. Physiological studies have described TRPML1 channels as
proton leak channels in
lysosome
A lysosome () is a membrane-bound organelle found in many animal cells. They are spherical vesicles that contain hydrolytic enzymes that can break down many kinds of biomolecules. A lysosome has a specific composition, of both its membrane pr ...
s responsible for preventing these organelles from becoming too acidic.
TRPML2 and
TRPML3 more poorly characterized than
TRPML1.
Deficiencies can lead to enlarged vesicles.
Genes
* (
TRPML1)
* (
TRPML2)
* (
TRPML3)
References
External links
*
*
{{Transient receptor potential channel modulators
Membrane proteins
Ion channels