Trional (Methylsulfonal) is a

sedative-hypnotic A sedative or tranquilliser is a substance that induces sedation by reducing irritability or excitement. They are CNS depressants and interact with brain activity causing its deceleration. Various kinds of sedatives can be distinguished, but th ...

and

anesthetic An anesthetic (American English) or anaesthetic (British English; see spelling differences) is a drug used to induce anesthesia ⁠— ⁠in other words, to result in a temporary loss of sensation or awareness. They may be divided into two ...

drug A drug is any chemical substance that causes a change in an organism's physiology or psychology when consumed. Drugs are typically distinguished from food and substances that provide nutritional support. Consumption of drugs can be via insuffla ...

with

GABAergic In molecular biology and physiology, something is GABAergic or GABAnergic if it pertains to or affects the neurotransmitter GABA. For example, a synapse is GABAergic if it uses GABA as its neurotransmitter, and a GABAergic neuron produces GABA. A ...

action Action may refer to: * Action (narrative), a literary mode * Action fiction, a type of genre fiction * Action game, a genre of video game Film * Action film, a genre of film * ''Action'' (1921 film), a film by John Ford * ''Action'' (1980 fil ...

s. It has similar effects to

sulfonal Sulfonmethane (Sulfonomethane, Sulfonal, Acetone diethyl sulfone) is a chemical compound first synthesized by Eugen Baumann in 1888 and introduced as a hypnotic drug by Alfred Kast later on, but now superseded by newer and safer sedatives. Its a ...

, except it is faster acting.

History

Trional was prepared and introduced by

Eugen Baumann Eugen Baumann (12 December 1846 – 3 November 1896) was a German chemist. He was one of the first people to create polyvinyl chloride (PVC), and, together with Carl Schotten, he discovered the Schotten-Baumann reaction. Life Baumann was born i ...

and

Alfred Kast Alfred Kast (25 July 1856 in Illenau, near Achern – 7 January 1903) was a German internist. He studied medicine at the Universities of Heidelberg, Freiburg and Leipzig, earning his doctorate in 1879. He served as an assistant to Wilhelm Heinri ...

in 1888. Appeared in Agatha Christie's "

Murder on the Orient Express ''Murder on the Orient Express'' is a work of detective fiction by English writer Agatha Christie featuring the Belgian detective Hercule Poirot. It was first published in the United Kingdom by the Collins Crime Club on 1 January 1934. In the U ...

", "

And Then There Were None ''And Then There Were None'' is a mystery novel by the English writer Agatha Christie, described by her as the most difficult of her books to write. It was first published in the United Kingdom by the Collins Crime Club on 6 November 1939, as ...

" and other novels such as John Bude’s “

The Lake District Murder ''The Lake District Murder'' is a 1935 detective novel by the British writer John Bude.Hubin p.56 It is the first in a series of novels featuring Chief Inspector Meredith, promoted at the end of case to Superintendent. Set in the Lake District of ...

” as a sleep inducing sedative, and in

In Search of Lost Time ''In Search of Lost Time'' (french: À la recherche du temps perdu), first translated into English as ''Remembrance of Things Past'', and sometimes referred to in French as ''La Recherche'' (''The Search''), is a novel in seven volumes by French ...

(Sodom and Gomorrah) by

Marcel Proust Valentin Louis Georges Eugène Marcel Proust (; ; 10 July 1871 – 18 November 1922) was a French novelist, critic, and essayist who wrote the monumental novel ''In Search of Lost Time'' (''À la recherche du temps perdu''; with the previous Eng ...

as a

hypnotic Hypnotic (from Greek ''Hypnos'', sleep), or soporific drugs, commonly known as sleeping pills, are a class of (and umbrella term for) psychoactive drugs whose primary function is to induce sleep (or surgical anesthesiaWhen used in anesthesia ...

Sax Rohmer Arthur Henry "Sarsfield" Ward (15 February 1883 – 1 June 1959), better known as Sax Rohmer, was an English novelist. He is best remembered for his series of novels featuring the master criminal Dr. Fu Manchu."Rohmer, Sax" by Jack Adrian in Da ...

also references trional in his novel '' Dope''.

References

Hypnotics GABAA receptor positive allosteric modulators Sulfones {{sedative-stub

History

See also

References