Sticky mouse is a
murine
The Old World rats and mice, part of the subfamily Murinae in the family Muridae, comprise at least 519 species. Members of this subfamily are called murines. In terms of species richness, this subfamily is larger than all mammal families ex ...
possessing a gene mutation in the enzyme
alanyl-tRNA synthetase (AARS).
The sticky mouse, with this particular mutation, presents a good model in which to investigate mechanisms of
neuronal degeneration
A neurodegenerative disease is caused by the progressive loss of structure or function of neurons, in the process known as neurodegeneration. Such neuronal damage may ultimately involve cell death. Neurodegenerative diseases include amyotrophi ...
. Its most immediately obvious symptom is a sticky secretion on the mouse's fur (thus the name); however, it is accompanied by lack of muscle control,
ataxia
Ataxia is a neurological sign consisting of lack of voluntary coordination of muscle movements that can include gait abnormality, speech changes, and abnormalities in eye movements. Ataxia is a clinical manifestation indicating dysfunction of t ...
,
alopecia
Hair loss, also known as alopecia or baldness, refers to a loss of hair from part of the head or body. Typically at least the head is involved. The severity of hair loss can vary from a small area to the entire body. Inflammation or scarr ...
, loss of
Purkinje cell
Purkinje cells, or Purkinje neurons, are a class of GABAergic inhibitory neurons located in the cerebellum. They are named after their discoverer, Czech anatomist Jan Evangelista Purkyně, who characterized the cells in 1839.
Structure
The ...
s in the
cerebellum
The cerebellum (Latin for "little brain") is a major feature of the hindbrain of all vertebrates. Although usually smaller than the cerebrum, in some animals such as the mormyrid fishes it may be as large as or even larger. In humans, the cere ...
, and eventually, death.
Sticky
mouse
A mouse ( : mice) is a small rodent. Characteristically, mice are known to have a pointed snout, small rounded ears, a body-length scaly tail, and a high breeding rate. The best known mouse species is the common house mouse (''Mus musculus' ...
is one of several
animal
Animals are multicellular, eukaryotic organisms in the Kingdom (biology), biological kingdom Animalia. With few exceptions, animals Heterotroph, consume organic material, Cellular respiration#Aerobic respiration, breathe oxygen, are Motilit ...
mutants that are known to have problems in
mRNA
In molecular biology, messenger ribonucleic acid (mRNA) is a single-stranded molecule of RNA that corresponds to the genetic sequence of a gene, and is read by a ribosome in the process of synthesizing a protein.
mRNA is created during the ...
translation and are used in studies.
See also
*
Wasted mouse
Wasted may refer to:
Arts, entertainment, and media Literature
*'' Wasted: Tales of a GenX Drunk'', a 1997 memoir by Mark Judge
*'' Wasted: A Memoir of Anorexia and Bulimia'', a 1998 autobiography by Marya Hornbacher
*'' Wasted: A Childhood Sto ...
(wst) -
EEF1A2
Elongation factor 1-alpha 2 is a protein that in humans is encoded by the ''EEF1A2'' gene.
Function
This gene encodes an isoform of the alpha subunit of the elongation factor-1 complex, which is responsible for the enzymatic delivery of amino ...
defect
*
Harlequin mouse
Harlequin (; it, Arlecchino ; lmo, Arlechin, Bergamasque pronunciation ) is the best-known of the ''zanni'' or comic servant characters from the Italian ''commedia dell'arte'', associated with the city of Bergamo. The role is traditionally b ...
*
Reeler
A reeler is a mouse mutant, so named because of its characteristic "reeling" gait. This is caused by the profound underdevelopment of the mouse's cerebellum, a segment of the brain responsible for locomotion. The mutation is autosomal and recess ...
-
RELN defect
*
Shaking rat Kawasaki
A laboratory rat or lab rat is a brown rat of the subspecies '' Rattus norvegicus domestica'' which is bred and kept for scientific research. While less commonly used for research than mice (see laboratory mouse), rats have served as an import ...
-
RELN defect
References
External links
A sticky wicket- editor's summary, Nature, 2006
Forward Genetics Reveals Novel Mechanisms of Neurodegeneration- free online videolecture by Ackerman SL.; June 2009
- Howard Hughes Medical Institute, 2006
- bio at the Institute site
Rodent diseases
Laboratory mouse strains
Behavioural genetics
{{veterinary-med-stub