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House Mouse
The house mouse (''Mus musculus'') is a small mammal of the order Rodentia, characteristically having a pointed snout, large rounded ears, and a long and almost hairless tail. It is one of the most abundant species of the genus '' Mus''. Although a wild animal, the house mouse has benefited significantly from associating with human habitation to the point that truly wild populations are significantly less common than the semi-tame populations near human activity. The house mouse has been domesticated as the pet or fancy mouse, and as the laboratory mouse, which is one of the most important model organisms in biology and medicine. The complete mouse reference genome was sequenced in 2002. Characteristics House mice have an adult body length (nose to base of tail) of and a tail length of . The weight is typically . In the wild they vary in color from grey and light brown to black (individual hairs are actually agouti coloured), but domesticated fancy mice and laboratory mice ar ...
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Carl Linnaeus
Carl Linnaeus (; 23 May 1707 – 10 January 1778), also known after his ennoblement in 1761 as Carl von Linné Blunt (2004), p. 171. (), was a Swedish botanist, zoologist, taxonomist, and physician who formalised binomial nomenclature, the modern system of naming organisms. He is known as the "father of modern taxonomy". Many of his writings were in Latin; his name is rendered in Latin as and, after his 1761 ennoblement, as . Linnaeus was born in Råshult, the countryside of Småland, in southern Sweden. He received most of his higher education at Uppsala University and began giving lectures in botany there in 1730. He lived abroad between 1735 and 1738, where he studied and also published the first edition of his ' in the Netherlands. He then returned to Sweden where he became professor of medicine and botany at Uppsala. In the 1740s, he was sent on several journeys through Sweden to find and classify plants and animals. In the 1750s and 1760s, he continued to collect an ...
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Whole Genome Sequencing
Whole genome sequencing (WGS), also known as full genome sequencing, complete genome sequencing, or entire genome sequencing, is the process of determining the entirety, or nearly the entirety, of the DNA sequence of an organism's genome at a single time. This entails sequencing all of an organism's chromosomal DNA as well as DNA contained in the mitochondrial DNA, mitochondria and, for plants, in the chloroplast. Whole genome sequencing has largely been used as a research tool, but was being introduced to clinics in 2014. In the future of personalized medicine, whole genome sequence data may be an important tool to guide therapeutic intervention. The tool of DNA sequencing, gene sequencing at Single-nucleotide polymorphism, SNP level is also used to pinpoint functional variants from association studies and improve the knowledge available to researchers interested in evolutionary biology, and hence may lay the foundation for predicting disease susceptibility and drug response. ...
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Lagomorpha
The lagomorphs are the members of the taxonomic order Lagomorpha, of which there are two living families: the Leporidae (hares and rabbits) and the Ochotonidae (pikas). The name of the order is derived from the Ancient Greek ''lagos'' (λαγώς, "hare") + ''morphē'' (μορφή, "form"). There are 110 recent species of lagomorph of which 109 are extant, including 34 species of pika, 42 species of rabbit, and 33 species of hare. Taxonomy and evolutionary history Other names used for this order, now considered synonymous, include: ''Duplicidentata'' - Illiger, 1811; ''Leporida'' - Averianov, 1999; ''Neolagomorpha'' - Averianov, 1999; ''Ochotonida'' - Averianov, 1999; and ''Palarodentia'' - Haeckel, 1895, Lilian, 2016. The evolutionary history of the lagomorphs is still not well understood. Until recently, it was generally agreed that '' Eurymylus'', which lived in eastern Asia and dates back to the late Paleocene or early Eocene, was an ancestor of the lagomorphs. More re ...
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Euarchontoglires
Euarchontoglires (synonymous with Supraprimates) is a clade and a superorder of mammals, the living members of which belong to one of the five following groups: rodents, lagomorphs, treeshrews, colugos, and primates. Evolutionary affinities within mammals The Euarchontoglires clade is based on DNA sequence analyses and retrotransposon markers that combine the clades Glires (Rodentia + Lagomorpha) and Euarchonta (Scandentia + Primates + Dermoptera). It is usually discussed without a taxonomic rank but has been called a cohort, magnorder, or superorder. Relations among the four cohorts (Euarchontoglires, Xenarthra, Laurasiatheria, Afrotheria) and the identity of the placental root remain controversial. So far, few, if any, distinctive anatomical features have been recognized that support Euarchontoglires; nor does any strong evidence from anatomy support alternative hypotheses. Although both Euarchontoglires and diprotodont marsupials are documented to possess a vermiform appen ...
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Thymus
The thymus is a specialized primary lymphoid organ of the immune system. Within the thymus, thymus cell lymphocytes or ''T cells'' mature. T cells are critical to the adaptive immune system, where the body adapts to specific foreign invaders. The thymus is located in the upper front part of the chest, in the anterior superior mediastinum, behind the sternum, and in front of the heart. It is made up of two lobes, each consisting of a central medulla and an outer cortex, surrounded by a capsule. The thymus is made up of immature T cells called thymocytes, as well as lining cells called epithelial cells which help the thymocytes develop. T cells that successfully develop react appropriately with MHC immune receptors of the body (called ''positive selection'') and not against proteins of the body (called ''negative selection''). The thymus is largest and most active during the neonatal and pre-adolescent periods. By the early teens, the thymus begins to decrease in size and a ...
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Tripod Stance
A tripod stance is a behaviour in which quadruped animals rear up on their hind legs and use their tail to support this position. Several animals use this behaviour to improve observation or surveillance, and during feeding, grooming, thermoregulation, or fighting. In mammals The common dwarf mongoose (''Helogale parvula'') adopts a tripod stance when being vigilant for predators. In a similar mammal, the thirteen-lined ground squirrel (''Spermophilus tridecemlineatus''), vigilance behaviour includes four postures: (1) quadrupedal alert (all four feet on the ground with head above the horizontal); (2) semiupright alert (on hind feet with a distinctive slouch); (3) upright alert (on hind feet with back straight and mostly perpendicular to the ground); (4) extended upright alert (similar to upright alert except that the squirrel extends its hind legs, (see image of meerkats). In meerkats (''Suricata suricatta''), the tripod stance may be adopted relatively briefly during foraging, ...
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Arteriovenous Anastomosis
A circulatory anastomosis is a connection (an anastomosis) between two blood vessels, such as between arteries (arterio-arterial anastomosis), between veins (veno-venous anastomosis) or between an artery and a vein (arterio-venous anastomosis). Anastomoses between arteries and between veins result in a multitude of arteries and veins, respectively, serving the same volume of tissue. Such anastomoses occur normally in the body in the circulatory system, serving as backup routes for blood to flow if one link is blocked or otherwise compromised, but may also occur pathologically. Physiologic Arterio-arterial anastomoses include actual (e.g., palmar and plantar arches) and potential varieties (e.g., coronary arteries and cortical branch of cerebral arteries). There are many examples of normal arterio-arterial anastomoses in the body. Clinically important examples include: *Circle of Willis (in the brain) *Coronary: anterior interventricular artery and posterior interventricular art ...
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Thermoregulation
Thermoregulation is the ability of an organism to keep its body temperature within certain boundaries, even when the surrounding temperature is very different. A thermoconforming organism, by contrast, simply adopts the surrounding temperature as its own body temperature, thus avoiding the need for internal thermoregulation. The internal thermoregulation process is one aspect of homeostasis: a state of dynamic stability in an organism's internal conditions, maintained far from thermal equilibrium with its environment (the study of such processes in zoology has been called physiological ecology). If the body is unable to maintain a normal temperature and it increases significantly above normal, a condition known as hyperthermia occurs. Humans may also experience lethal hyperthermia when the wet bulb temperature is sustained above for six hours. The opposite condition, when body temperature decreases below normal levels, is known as hypothermia. It results when the homeostatic c ...
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Testicle
A testicle or testis (plural testes) is the male reproductive gland or gonad in all bilaterians, including humans. It is homologous to the female ovary. The functions of the testes are to produce both sperm and androgens, primarily testosterone. Testosterone release is controlled by the anterior pituitary luteinizing hormone, whereas sperm production is controlled both by the anterior pituitary follicle-stimulating hormone and gonadal testosterone. Structure Appearance Males have two testicles of similar size contained within the scrotum, which is an extension of the abdominal wall. Scrotal asymmetry, in which one testicle extends farther down into the scrotum than the other, is common. This is because of the differences in the vasculature's anatomy. For 85% of men, the right testis hangs lower than the left one. Measurement and volume The volume of the testicle can be estimated by palpating it and comparing it to ellipsoids of known sizes. Another method is to use caliper ...
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Nipple
The nipple is a raised region of tissue on the surface of the breast from which, in females, milk leaves the breast through the lactiferous ducts to feed an infant. The milk can flow through the nipple passively or it can be ejected by smooth muscle contractions that occur along with the ductal system. The nipple is surrounded by the areola, which is often a darker colour than the surrounding skin. A nipple is often called a teat when referring to non-humans. Nipple or teat can also be used to describe the flexible mouthpiece of a baby bottle. In humans, the nipples of both males and females can be stimulated as part of sexual arousal. In many cultures, human female nipples are sexualized, or "regarded as sex objects and evaluated in terms of their physical characteristics and sexiness." Anatomy In mammals, a nipple (also called mammary papilla or teat) is a small projection of skin containing the outlets for 15–20 lactiferous ducts arranged cylindrically around the tip. Ma ...
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Mammary Gland
A mammary gland is an exocrine gland in humans and other mammals that produces milk to feed young offspring. Mammals get their name from the Latin word ''mamma'', "breast". The mammary glands are arranged in organs such as the breasts in primates (for example, humans and chimpanzees), the udder in ruminants (for example, cows, goats, sheep, and deer), and the dugs of other animals (for example, dogs and cats). Lactorrhea, the occasional production of milk by the glands, can occur in any mammal, but in most mammals, lactation, the production of enough milk for nursing, occurs only in phenotypic females who have gestated in recent months or years. It is directed by hormonal guidance from sex steroids. In a few mammalian species, male lactation can occur. With humans, male lactation can occur only under specific circumstances. Mammals are divided into 3 groups: prototherians, metatherians, and eutherians. In the case of prototherians, both males and females have functional mamm ...
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Anogenital Distance
Anogenital distance (AGD) is the distance from the midpoint of the anus to the Sex organ, genitalia, the underside of the vagina, the clitoris or the scrotum. It is considered medically significant for a number of reasons, in both humans and other animals, including sex assignment, sex determination and as a marker of endocrine disruptor exposure. It is regulated by dihydrotestosterone, which can be disrupted by phthalates common in plastics. The ''anogenital index'' (AGI) is an index used to compare the AGD relative to a model based on body weight. It is computed as the AGD divided by weight [AGI = AGD/weight (mm/kg)]. Measurement The AGD is usually measured as follows: from the center of the anus to the Posterior (anatomy), posterior convergence of the Frenulum of labia minora, fourchette (where the Vulval vestibule, vestibule begins) in females (AGD-AF); and from the center of the anus to the junction of the smooth Perineum, perineal skin with the rugate skin of the scrotum i ...
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