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Stanley Rossiter Benedict (17 March 1884 – 21 December 1936) was an American
chemist A chemist (from Greek ''chēm(ía)'' alchemy; replacing ''chymist'' from Medieval Latin ''alchemist'') is a scientist trained in the study of chemistry. Chemists study the composition of matter and its properties. Chemists carefully describe th ...
best known for discovering
Benedict's reagent Benedict's reagent (often called Benedict's qualitative solution or Benedict's solution) is a chemical reagent and complex mixture of sodium carbonate, sodium citrate, and copper(II) sulfate pentahydrate. It is often used in place of Fehling' ...
, a solution that detects certain
sugar Sugar is the generic name for sweet-tasting, soluble carbohydrates, many of which are used in food. Simple sugars, also called monosaccharides, include glucose, fructose, and galactose. Compound sugars, also called disaccharides or double ...
s.


Personal life

Stanley Rossiter Benedict was born on March 17, 1884 to a big family of six children in
Cincinnati Cincinnati ( ) is a city in the U.S. state of Ohio and the county seat of Hamilton County. Settled in 1788, the city is located at the northern side of the confluence of the Licking and Ohio rivers, the latter of which marks the state line wit ...
. His father, Wayland Richardson Benedict was a professor of Philosophy and Psychology at the University of Cincinnati. His mother, Anne Kendrick Benedict, was a writer and a teacher and his maternal grandmother, a Professor of
Greek Greek may refer to: Greece Anything of, from, or related to Greece, a country in Southern Europe: *Greeks, an ethnic group. *Greek language, a branch of the Indo-European language family. **Proto-Greek language, the assumed last common ancestor ...
,
Latin Latin (, or , ) is a classical language belonging to the Italic branch of the Indo-European languages. Latin was originally a dialect spoken in the lower Tiber area (then known as Latium) around present-day Rome, but through the power of the ...
and
Sanskrit Sanskrit (; attributively , ; nominally , , ) is a classical language belonging to the Indo-Aryan branch of the Indo-European languages. It arose in South Asia after its predecessor languages had diffused there from the northwest in the late ...
at the
University of Rochester The University of Rochester (U of R, UR, or U of Rochester) is a private research university in Rochester, New York. The university grants undergraduate and graduate degrees, including doctoral and professional degrees. The University of Roc ...
and was an editor of the King James Version of the Bible. In 1914, Stanley R. Benedict married Ruth Fulton. However, their marriage was strained by their inability to have children, Ruth's writing career and her secret love affair with her female friend and colleague
Margaret Mead Margaret Mead (December 16, 1901 – November 15, 1978) was an American cultural anthropologist who featured frequently as an author and speaker in the mass media during the 1960s and the 1970s. She earned her bachelor's degree at Barnard Co ...
which led to a separation in 1930. ''The Bo-Cu Plant'', written by Ruth Benedict is an illustration of her married life with Stanley. During World War I (1914-1918), Stanley had an accident and was gassed while working on a government project concerning poisonous gas which had a negative impact on his health.


Education and Career

Benedict went to the
Cincinnati Cincinnati ( ) is a city in the U.S. state of Ohio and the county seat of Hamilton County. Settled in 1788, the city is located at the northern side of the confluence of the Licking and Ohio rivers, the latter of which marks the state line wit ...
public schools and
University of Cincinnati The University of Cincinnati (UC or Cincinnati) is a public research university in Cincinnati, Ohio. Founded in 1819 as Cincinnati College, it is the oldest institution of higher education in Cincinnati and has an annual enrollment of over 44,00 ...
. His plan was to enroll into medical school after his graduation. However, Stanley gave up the medical school for a career in Biochemistry and metabolism after working with Dr J.F. Snell, an expert in Biochemistry and Nutrition at the
University of Cincinnati The University of Cincinnati (UC or Cincinnati) is a public research university in Cincinnati, Ohio. Founded in 1819 as Cincinnati College, it is the oldest institution of higher education in Cincinnati and has an annual enrollment of over 44,00 ...
. He received his
B.A. Bachelor of arts (BA or AB; from the Latin ', ', or ') is a bachelor's degree awarded for an undergraduate program in the arts, or, in some cases, other disciplines. A Bachelor of Arts degree course is generally completed in three or four years ...
degree in Chemistry in 1906 at the
University of Cincinnati The University of Cincinnati (UC or Cincinnati) is a public research university in Cincinnati, Ohio. Founded in 1819 as Cincinnati College, it is the oldest institution of higher education in Cincinnati and has an annual enrollment of over 44,00 ...
and his
PhD PHD or PhD may refer to: * Doctor of Philosophy (PhD), an academic qualification Entertainment * '' PhD: Phantasy Degree'', a Korean comic series * ''Piled Higher and Deeper'', a web comic * Ph.D. (band), a 1980s British group ** Ph.D. (Ph.D. albu ...
two years after (1908) in
Physiological Chemistry Biochemistry or biological chemistry is the study of chemical processes within and relating to living organisms. A sub-discipline of both chemistry and biology, biochemistry may be divided into three fields: structural biology, enzymology and ...
at
Yale University Yale University is a private research university in New Haven, Connecticut. Established in 1701 as the Collegiate School, it is the third-oldest institution of higher education in the United States and among the most prestigious in the wo ...
by working with Russel H. Chittenden and Lafayette Benedict Mendel. Stanley got famous through
Otto Folin Otto Knut Olof Folin (April 4, 1867 – October 25, 1934) was a Swedish-born American chemist who is best known for his groundbreaking work at Harvard University on practical micromethods for the determination of the constituents of protein-f ...
's work after this latter published the volume 13 of ''
American Journal of Physiology The ''American Journal of Physiology'' is a peer-reviewed scientific journal on physiology published by the American Physiological Society. Vols. for 1898–1941 and 1948-56 include the Society's proceedings, including abstracts of papers presente ...
''. Folin described in the Journal some methods on how to analyze qualitatively and quantitatively some elements in the urine such as
urea Urea, also known as carbamide, is an organic compound with chemical formula . This amide has two amino groups (–) joined by a carbonyl functional group (–C(=O)–). It is thus the simplest amide of carbamic acid. Urea serves an important r ...
,
uric acid Uric acid is a heterocyclic compound of carbon, nitrogen, oxygen, and hydrogen with the formula C5H4N4O3. It forms ions and salts known as urates and acid urates, such as ammonium acid urate. Uric acid is a product of the metabolic breakdown of ...
,
ammonia Ammonia is an inorganic compound of nitrogen and hydrogen with the formula . A stable binary hydride, and the simplest pnictogen hydride, ammonia is a colourless gas with a distinct pungent smell. Biologically, it is a common nitrogenous was ...
,
creatine Creatine ( or ) is an organic compound with the nominal formula (H2N)(HN)CN(CH3)CH2CO2H. It exists in various modifications (tautomers) in solution. Creatine is found in vertebrates where it facilitates recycling of adenosine triphosphate ( ...
, and
creatinine Creatinine (; ) is a breakdown product of creatine phosphate from muscle and protein metabolism. It is released at a constant rate by the body (depending on muscle mass). Biological relevance Serum creatinine (a blood measurement) is an import ...
. Benedict was also interested into how to quantify the rate of sugar in blood and urine, so he came up with a more efficient, simple methods which practically replace all of Folin's ones. After his doctorate, he taught Chemistry for one year at the University of Syracuse and Biological Chemistry the following year at
Columbia University Columbia University (also known as Columbia, and officially as Columbia University in the City of New York) is a private research university in New York City. Established in 1754 as King's College on the grounds of Trinity Church in Manhatt ...
. From 1910 to 1936, Benedict taught Biochemistry at the medical school of Cornell University while at the same time running the
Journal of Biological Chemistry The ''Journal of Biological Chemistry'' (''JBC'') is a weekly peer-reviewed scientific journal that was established in 1905., jbc.org Since 1925, it is published by the American Society for Biochemistry and Molecular Biology. It covers research in ...
as an editor in chief.


Scientific Societies

Stanley Benedict was part of many Chemistry societies. He was a member of the National Academy of Sciences, American Association for the Advancement of Science, American Society of Biological Chemists (President 1919-1920), American Physiological Society, Phi Beta Kappa, Corresponding Member of the Societe Biologie de Paris, Sigma Xi, Alpha Omega Alpha, The Harvey Society, Associate Fellow of the New York Academy of Medicine.


Death

Stanley Benedict died of heart attack at the age of 52 in
Elmsford, New York Elmsford is a village in Westchester County, New York, United States. It is part of the New York metropolitan area. Roughly one mile square, the village is fully contained within the borders of the town of Greenburgh. As of the 2010 census, the ...
on December 21, 1936. He is buried at Forest Hills Cemetery and Crematory, Massachusetts.


References

* {{DEFAULTSORT:Benedict, Stanley Rossiter 1884 births 1936 deaths 20th-century American chemists Scientists from Cincinnati University of Cincinnati alumni Yale Graduate School of Arts and Sciences alumni Journal of Biological Chemistry editors