S-phase kinase-associated protein 1 is an
enzyme
Enzymes () are proteins that act as biological catalysts by accelerating chemical reactions. The molecules upon which enzymes may act are called substrates, and the enzyme converts the substrates into different molecules known as products. A ...
that in humans is encoded by the ''SKP1''
gene
In biology, the word gene (from , ; "...Wilhelm Johannsen coined the word gene to describe the Mendelian units of heredity..." meaning ''generation'' or ''birth'' or ''gender'') can have several different meanings. The Mendelian gene is a ba ...
.
This gene encodes a
protein
Proteins are large biomolecules and macromolecules that comprise one or more long chains of amino acid residues. Proteins perform a vast array of functions within organisms, including catalysing metabolic reactions, DNA replication, respo ...
that is a member of the
SCF ubiquitin ligase
A ubiquitin ligase (also called an E3 ubiquitin ligase) is a protein that recruits an E2 ubiquitin-conjugating enzyme that has been loaded with ubiquitin, recognizes a protein substrate, and assists or directly catalyzes the transfer of ubiquitin ...
protein complex
A protein complex or multiprotein complex is a group of two or more associated polypeptide chains. Protein complexes are distinct from multienzyme complexes, in which multiple catalytic domains are found in a single polypeptide chain.
Protein c ...
. It binds to
F-box proteins
F-box proteins are proteins containing at least one F-box domain. The first identified F-box protein is one of three components of the SCF complex, which mediates ubiquitination of proteins targeted for degradation by the 26S proteasome.
Core c ...
(proteins containing an F-box motif), such as cyclin F,
S-phase kinase-associated protein 2, and other regulatory proteins involved in
ubiquitin
Ubiquitin is a small (8.6 kDa) regulatory protein found in most tissues of eukaryotic organisms, i.e., it is found ''ubiquitously''. It was discovered in 1975 by Gideon Goldstein and further characterized throughout the late 1970s and 1980s. Fo ...
dependent proteolysis.
The encoded protein also collaborates with a network of proteins to control beta-catenin levels and affects the activity level of beta-catenin dependent TCF transcription factors. Studies have also characterized the protein as an RNA polymerase II elongation factor.
Alternative splicing
Alternative splicing, or alternative RNA splicing, or differential splicing, is an alternative splicing process during gene expression that allows a single gene to code for multiple proteins. In this process, particular exons of a gene may be ...
of this gene results in two transcript variants. A related
pseudogene
Pseudogenes are nonfunctional segments of DNA that resemble functional genes. Most arise as superfluous copies of functional genes, either directly by DNA duplication or indirectly by Reverse transcriptase, reverse transcription of an mRNA trans ...
has been identified on chromosome 7.
Interactions
SKP1A has been shown to
interact
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with:
*
BTRC,
CACYBP
Calcyclin-binding protein is a protein that in humans is encoded by the ''CACYBP'' gene.
The protein encoded by this gene is a calcyclin binding protein. It may be involved in calcium-dependent ubiquitination and subsequent proteosomal degradatio ...
,CDCA3
Cell division cycle-associated protein 3 is a protein that in humans is encoded by the ''CDCA3'' gene.
Interactions
CDCA3 has been shown to interact
Advocates for Informed Choice, doing business as, dba interACT or interACT Advocates for Int ...
,CDK9
Cyclin-dependent kinase 9 or CDK9 is a cyclin-dependent kinase associated with P-TEFb.
Function
The protein encoded by this gene is a member of the cyclin-dependent kinase (CDK) family. CDK family members are highly similar to the gene produ ...
,FBXL3
''FBXL3'' is a gene in humans and mice that encodes the F-box/LRR-repeat protein 3 (FBXL3).
FBXL3 is a member of the F-box protein family, which constitutes one of the four subunits in the SCF ubiquitin ligase complex.
The FBXL3 protein partici ...
,FBXO4
F-box only protein 4 is a protein that in humans is encoded by the ''FBXO4'' gene.
Function
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins co ...
,FBXO5
F-box only protein 5 is a protein that in humans is encoded by the ''FBXO5'' gene.
Function
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins con ...
,[
* ]FBXO7
F-box only protein 7 is a protein that in humans is encoded by the ''FBXO7'' gene. Mutations in FBXO7 have been associated with Parkinson's disease.
Function
This gene encodes a member of the F-box protein family which is characterized by an ap ...
,[
* ]FBXW2
F-box/WD repeat-containing protein 2 is a protein that in humans is encoded by the ''FBXW2'' gene.
Function
F-box proteins are an expanding family of eukaryotic proteins characterized by an approximately 40 amino acid motif, the F box. Some F- ...
,[
* ]FBXW7
F-box/WD repeat-containing protein 7 is a protein that in humans is encoded by the ''FBXW7'' gene.
Function
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F ...
,SKP2
S-phase kinase-associated protein 2 is an enzyme that in humans is encoded by the ''SKP2'' gene.
Structure and function
Skp2 contains 424 residues in total with the ~40 amino acid F-box domain lying closer to the N-terminal region at the 94-1 ...
.
References
Further reading
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External links
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{{PDB Gallery, geneid=6500