Sir Alan Roy Fersht
(born 21 April 1943) is a British
chemist
A chemist (from Greek ''chēm(ía)'' alchemy; replacing ''chymist'' from Medieval Latin ''alchemist'') is a scientist trained in the study of chemistry. Chemists study the composition of matter and its properties. Chemists carefully describe th ...
at the
MRC Laboratory of Molecular Biology
The Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) is a research institute in Cambridge, England, involved in the revolution in molecular biology which occurred in the 1950–60s. Since then it has remained a major medical r ...
, Cambridge, and an
Emeritus
''Emeritus'' (; female: ''emerita'') is an adjective used to designate a retired chair, professor, pastor, bishop, pope, director, president, prime minister, rabbi, emperor, or other person who has been "permitted to retain as an honorary title ...
Professor in the
Department of Chemistry at the
University of Cambridge
, mottoeng = Literal: From here, light and sacred draughts.
Non literal: From this place, we gain enlightenment and precious knowledge.
, established =
, other_name = The Chancellor, Masters and Schola ...
. He was
Master
Master or masters may refer to:
Ranks or titles
* Ascended master, a term used in the Theosophical religious tradition to refer to spiritually enlightened beings who in past incarnations were ordinary humans
*Grandmaster (chess), National Master ...
of
Gonville and Caius College, Cambridge
Gonville and Caius College, often referred to simply as Caius ( ), is a constituent college of the University of Cambridge in Cambridge, England. Founded in 1348, it is the fourth-oldest of the University of Cambridge's 31 colleges and one of th ...
from 2012 to 2018.
He works on
protein folding
Protein folding is the physical process by which a protein chain is translated to its native three-dimensional structure, typically a "folded" conformation by which the protein becomes biologically functional. Via an expeditious and reproduci ...
, and is sometimes described as a founder of
protein engineering
Protein engineering is the process of developing useful or valuable proteins. It is a young discipline, with much research taking place into the understanding of protein folding and recognition for protein design principles. It has been used to imp ...
.
Early life and education
Fersht was born on 21 April 1943
[ ] in
Hackney, London. His father, Philip, was a ladies' tailor and his mother, Betty, a dressmaker. His grandparents were Jewish immigrants from Poland, Romania, Lithuania and Belarus. He was educated at
Sir George Monoux Grammar School
''Sir'' is a formal honorific address in English for men, derived from Sire in the High Middle Ages. Both are derived from the old French "Sieur" (Lord), brought to England by the French-speaking Normans, and which now exist in French only as ...
, an
all-boys grammar school in
Walthamstow
Walthamstow ( or ) is a large town in East London, east London, England, within the Ceremonial counties of England, ceremonial county of Greater London and the Historic counties of England, ancient county of Essex. Situated northeast of Chari ...
, London.
He was a keen chess player and was the Essex County Junior champion in 1961. He was awarded a
State Scholarship to read Natural Sciences at
Gonville and Caius College, Cambridge
Gonville and Caius College, often referred to simply as Caius ( ), is a constituent college of the University of Cambridge in Cambridge, England. Founded in 1348, it is the fourth-oldest of the University of Cambridge's 31 colleges and one of th ...
, where he obtained First Class in Pt I of the Natural Sciences Tripos in 1964, First Class in Pt II (Chemistry) in 1965 and was awarded his PhD degree in 1968.
He was President of the University of Cambridge Chess Club in 1964-65 and awarded a half blue in 1965.
Career and research
Fersht spent a post-doctoral year (1968–1969) at
Brandeis University
, mottoeng = "Truth even unto its innermost parts"
, established =
, type = Private research university
, accreditation = NECHE
, president = Ronald D. Liebowitz
, pro ...
working under
William Jencks
William Platt Jencks (August 15, 1927 – January 3, 2007) was an American biochemist. He was noted particularly for his work on enzymes, using concepts drawn from organic chemistry to understand their mechanisms.
Career
Jencks graduated from H ...
. He returned to Cambridge in 1969 as a group leader at the
Laboratory of Molecular Biology
The Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) is a research institute in Cambridge, England, involved in the revolution in molecular biology which occurred in the 1950–60s. Since then it has remained a major medical r ...
until 1977 and a junior
research fellow
A research fellow is an academic research position at a university or a similar research institution, usually for academic staff or faculty members. A research fellow may act either as an independent investigator or under the supervision of a pr ...
at
Jesus College, Cambridge
Jesus College is a constituent college of the University of Cambridge. The college's full name is The College of the Blessed Virgin Mary, Saint John the Evangelist and the glorious Virgin Saint Radegund, near Cambridge. Its common name comes fr ...
until 1972. Fersht was Wolfson Research Professor of the
Royal Society
The Royal Society, formally The Royal Society of London for Improving Natural Knowledge, is a learned society and the United Kingdom's national academy of sciences. The society fulfils a number of roles: promoting science and its benefits, re ...
and Professor of Biological Chemistry at
Imperial College London
Imperial College London (legally Imperial College of Science, Technology and Medicine) is a public research university in London, United Kingdom. Its history began with Prince Albert, consort of Queen Victoria, who developed his vision for a cu ...
from 1978 to 1988. He spent a sabbatical year at
Stanford University
Stanford University, officially Leland Stanford Junior University, is a private research university in Stanford, California. The campus occupies , among the largest in the United States, and enrolls over 17,000 students. Stanford is consider ...
on an Eleanor Roosevelt Fellowship of the
American Cancer Society
The American Cancer Society (ACS) is a nationwide voluntary health organization dedicated to eliminating cancer. Established in 1913, the society is organized into six geographical regions of both medical and lay volunteers operating in more than ...
with
Arthur Kornberg
Arthur Kornberg (March 3, 1918 – October 26, 2007) was an American biochemist who won the Nobel Prize in Physiology or Medicine 1959 for the discovery of "the mechanisms in the biological synthesis of ribonucleic acid and deoxyribonucleic ac ...
(1978–79). Fersht was
Herchel Smith
Herchel Smith (May 6, 1925 – December 20, 2001) was an Anglo-American organic chemist. His discoveries include the key inventions underlying oral and injectable contraceptives. In later life, he was a major benefactor to university science. In E ...
Professor of
Organic Chemistry
Organic chemistry is a subdiscipline within chemistry involving the scientific study of the structure, properties, and reactions of organic compounds and organic materials, i.e., matter in its various forms that contain carbon atoms.Clayden, J.; ...
at Cambridge from 1988 to 2010. He was the Director of the Cambridge
Centre for Protein Engineering {{Use dmy dates, date=April 2022
The MRC Centre for Protein Engineering (or CPE) was a pioneering research unit in Cambridge, England, with a main focus on the structure, stability and activity of proteins and engineering of antibodies.
Centre for ...
from 1990 to 2010 when, on reaching the retirement age, he became an Emeritus Group Leader at the
Laboratory of Molecular Biology
The Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) is a research institute in Cambridge, England, involved in the revolution in molecular biology which occurred in the 1950–60s. Since then it has remained a major medical r ...
. He is a Fellow of both Gonville & Caius College and Imperial College.
Alan Fersht is widely regarded as one of the main pioneers of
protein engineering
Protein engineering is the process of developing useful or valuable proteins. It is a young discipline, with much research taking place into the understanding of protein folding and recognition for protein design principles. It has been used to imp ...
, which he developed as a primary method for analysis of the structure, activity and folding of proteins. He has developed methods for the resolution of
protein folding
Protein folding is the physical process by which a protein chain is translated to its native three-dimensional structure, typically a "folded" conformation by which the protein becomes biologically functional. Via an expeditious and reproduci ...
in the sub-millisecond time-scale and has pioneered the method of
phi value analysis Phi value analysis,
\phi
analysis, or \phi-value analysis is an experimental protein engineering technique for studying the structure of the folding transition state of small protein domains that fold in a two-state manner. The structure of the f ...
for studying the folding transition states of proteins. His interests also include
protein misfolding
In medicine, proteinopathy (; 'pref''. protein -pathy 'suff''. disease proteinopathies ''pl''.; proteinopathic ''adj''), or proteopathy, protein conformational disorder, or protein misfolding disease refers to a class of diseases in which certa ...
, disease and cancer.
Selected publications
* ''Structure and Mechanism in Protein Science: A Guide to Enzyme Catalysis and Protein Folding''
* ''The Selected Papers of Sir Alan Fersht: Development of Protein Engineering''
Awards and honours
![Staircase L Gonville & Caius](https://upload.wikimedia.org/wikipedia/commons/f/fe/Staircase_L_Gonville_%26_Caius.jpg)
![L1Caius1994](https://upload.wikimedia.org/wikipedia/commons/3/32/L1Caius1994.jpg)
Fersht was elected a
Fellow of the Royal Society
Fellowship of the Royal Society (FRS, ForMemRS and HonFRS) is an award granted by the judges of the Royal Society of London to individuals who have made a "substantial contribution to the improvement of natural science, natural knowledge, incl ...
(FRS) in 1983.
The Royal Society awarded him the
Gabor Medal
The Gabor Medal is one of the medals awarded by the Royal Society for "acknowledged distinction of interdisciplinary work between the life sciences with other disciplines".
The medal was created in 1989 to honor the memory of physicist Denni ...
in 1991 for molecular biology, in 1998 the
Davy Medal
The Davy Medal is awarded by the Royal Society of London "for an outstandingly important recent discovery in any branch of chemistry". Named after Humphry Davy, the medal is awarded with a monetary gift, initially of £1000 (currently £2000).
H ...
for chemistry and in 2008 the
Royal Medal
The Royal Medal, also known as The Queen's Medal and The King's Medal (depending on the gender of the monarch at the time of the award), is a silver-gilt medal, of which three are awarded each year by the Royal Society, two for "the most important ...
. He is a Foreign Associate of the United States
National Academy of Sciences
The National Academy of Sciences (NAS) is a United States nonprofit, non-governmental organization. NAS is part of the National Academies of Sciences, Engineering, and Medicine, along with the National Academy of Engineering (NAE) and the Nati ...
,
a Foreign Member of the
American Philosophical Society
The American Philosophical Society (APS), founded in 1743 in Philadelphia, is a scholarly organization that promotes knowledge in the sciences and humanities through research, professional meetings, publications, library resources, and communit ...
, a Foreign Member of the
Accademia dei Lincei
The Accademia dei Lincei (; literally the "Academy of the Lynx-Eyed", but anglicised as the Lincean Academy) is one of the oldest and most prestigious European scientific institutions, located at the Palazzo Corsini on the Via della Lungara in Rom ...
, Member of
Academia Europaea
The Academia Europaea is a pan-European Academy of Humanities, Letters, Law, and Sciences.
The Academia was founded in 1988 as a functioning Europe-wide Academy that encompasses all fields of scholarly inquiry. It acts as co-ordinator of Europea ...
, an Honorary Foreign Member of the
American Academy of Arts and Sciences
The American Academy of Arts and Sciences (abbreviation: AAA&S) is one of the oldest learned societies in the United States. It was founded in 1780 during the American Revolution by John Adams, John Hancock, James Bowdoin, Andrew Oliver, and ...
and a
Fellow of the Academy of Medical Sciences
Fellowship of the Academy of Medical Sciences (FMedSci) is an award for medical scientists who are judged by the UK Academy of Medical Sciences for the "excellence of their science, their contribution to medicine and society and the range of th ...
(FMedSci).
[ His nomination for the Royal Society reads:
Fersht holds honorary doctorates from ]Uppsala University
Uppsala University ( sv, Uppsala universitet) is a public university, public research university in Uppsala, Sweden. Founded in 1477, it is the List of universities in Sweden, oldest university in Sweden and the Nordic countries still in opera ...
(1999), Vrije Universiteit Brussel
The Vrije Universiteit Brussel (VUB) () is a Dutch and English-speaking research university located in Brussels, Belgium.The Vrije Universiteit Brussel is one of the five universities officially recognised by the Flemish Community, Flemish gov ...
(1999), Weizmann Institute of Science
The Weizmann Institute of Science ( he, מכון ויצמן למדע ''Machon Vaitzman LeMada'') is a public research university in Rehovot, Israel, established in 1934, 14 years before the State of Israel. It differs from other Israeli unive ...
(2004), Hebrew University of Jerusalem
The Hebrew University of Jerusalem (HUJI; he, הַאוּנִיבֶרְסִיטָה הַעִבְרִית בִּירוּשָׁלַיִם) is a public research university based in Jerusalem, Israel. Co-founded by Albert Einstein and Dr. Chaim Weiz ...
(2006), and Aarhus University
Aarhus University ( da, Aarhus Universitet, abbreviated AU) is a public research university with its main campus located in Aarhus, Denmark. It is the second largest and second oldest university in Denmark. The university is part of the Coimbra Gr ...
(2008). He is an Honorary Fellow of Darwin College, Cambridge
Darwin College is a constituent college of the University of Cambridge. Founded on 28 July 1964, Darwin was Cambridge University's first graduate-only college, and also the first to admit both men and women. The college is named after one of the ...
(2014) and Jesus College, Cambridge
Jesus College is a constituent college of the University of Cambridge. The college's full name is The College of the Blessed Virgin Mary, Saint John the Evangelist and the glorious Virgin Saint Radegund, near Cambridge. Its common name comes fr ...
(2017).
Fersht has received many prizes and medals including: the FEBS The Federation of the European Biochemical Societies, frequently abbreviated FEBS, is an international scientific society promoting activities in biochemistry, molecular biology and related research areas in Europe and neighbouring regions. It was f ...
Anniversary Prize; Novo Biotechnology Award; Charmian Medal of the Royal Society of Chemistry
The Royal Society of Chemistry (RSC) is a learned society (professional association) in the United Kingdom with the goal of "advancing the chemistry, chemical sciences". It was formed in 1980 from the amalgamation of the Chemical Society, the Ro ...
; Max Tishler
Max Tishler (October 30, 1906 – March 18, 1989) was president of Merck Sharp and Dohme Research Laboratories where he led the research teams that synthesized ascorbic acid, riboflavin, cortisone, pyridoxine, pantothenic acid, nicotinamide, ...
Lecture and Prize Harvard University
Harvard University is a private Ivy League research university in Cambridge, Massachusetts. Founded in 1636 as Harvard College and named for its first benefactor, the Puritan clergyman John Harvard, it is the oldest institution of higher le ...
; The Datta Lectureship and Medal of the Federation of European Biochemical Societies The Federation of the European Biochemical Societies, frequently abbreviated FEBS, is an international scientific society promoting activities in biochemistry, molecular biology and related research areas in Europe and neighbouring regions. It was f ...
; Jubilee Lecture and the Harden Medal of the Biochemical Society
The Biochemical Society is a learned society in the United Kingdom in the field of biochemistry, including all the cellular and molecular biosciences.
Structure
It currently has around 7000 members, two-thirds in the UK. It is affiliated with th ...
; Feldberg Foundation Prize, Distinguished Service Award, Miami Nature
Nature, in the broadest sense, is the physics, physical world or universe. "Nature" can refer to the phenomenon, phenomena of the physical world, and also to life in general. The study of nature is a large, if not the only, part of science. ...
Biotechnology Winter Symposium; Christian B. Anfinsen Award of the Protein Society; Natural Products Award of the Royal Society of Chemistry
The Royal Society of Chemistry (RSC) is a learned society (professional association) in the United Kingdom with the goal of "advancing the chemistry, chemical sciences". It was formed in 1980 from the amalgamation of the Chemical Society, the Ro ...
, Stein and Moore Award of the Protein Society; Bader Award of the American Chemical Society
The American Chemical Society (ACS) is a scientific society based in the United States that supports scientific inquiry in the field of chemistry. Founded in 1876 at New York University, the ACS currently has more than 155,000 members at all d ...
; Kaj Ulrik Linderstrøm-Lang Kaj Ulrik Linderstrøm-Lang (29 November 1896 – 25 May 1959) was a Danish protein scientist, who was the director of the Carlsberg Laboratory from 1939 until his death.
His most notable scientific contributions were the development of sundry phys ...
Prize and Medal; Bijvoet Medal of the Bijvoet Center for Biomolecular Research
The Bijvoet Centre for Biomolecular Research is a research institute at Utrecht University. The Bijvoet Centre performs research on the relation between the structure and function of biomolecules, including proteins and lipids, which play a role ...
of Utrecht University
Utrecht University (UU; nl, Universiteit Utrecht, formerly ''Rijksuniversiteit Utrecht'') is a public research university in Utrecht, Netherlands. Established , it is one of the oldest universities in the Netherlands. In 2018, it had an enrollme ...
in 2008 and the Gilbert N. Lewis Medal University of California, Berkeley
The University of California, Berkeley (UC Berkeley, Berkeley, Cal, or California) is a public land-grant research university in Berkeley, California. Established in 1868 as the University of California, it is the state's first land-grant u ...
, and the Wilhelm Exner Medal The Wilhelm Exner Medal has been awarded by the Austrian Industry Association, (ÖGV), for excellence in research and science since 1921.
The medal is dedicated to Wilhelm Exner (1840–1931), former president of the Association, who initialized ...
in 2009.
In 2003 he was knight
A knight is a person granted an honorary title of knighthood by a head of state (including the Pope) or representative for service to the monarch, the church or the country, especially in a military capacity. Knighthood finds origins in the Gr ...
ed for his pioneering work on protein science. His citation on election to the Academy of Medical Sciences reads:
In August 2020 he was awarded the Copley Medal
The Copley Medal is an award given by the Royal Society, for "outstanding achievements in research in any branch of science". It alternates between the physical sciences or mathematics and the biological sciences. Given every year, the medal is t ...
of The Royal Society, for his development and application of methods of protein engineering to provide descriptions of protein folding pathways at atomic resolution.
Personal life
Fersht's recreations include chess
Chess is a board game for two players, called White and Black, each controlling an army of chess pieces in their color, with the objective to checkmate the opponent's king. It is sometimes called international chess or Western chess to disti ...
,[He has written an account of the history of Staunton and other chess sets. ] horology
Horology (; related to Latin '; ; , interfix ''-o-'', and suffix ''-logy''), . is the study of the measurement of time. Clocks, watches, clockwork, sundials, hourglasses, clepsydras, timers, time recorders, marine chronometers, and atomic cl ...
and wildlife photography
Wildlife photography is a genre of photography concerned with documenting various forms of wildlife in their natural habitat.
As well as requiring photography skills, wildlife photographers may need field craft skills. For example, some anima ...
. He married Marilyn Persell in 1966 and has one son and one daughter.[
]
References
External links
{{DEFAULTSORT:Fersht, Alan
1943 births
Living people
British chemists
British Jews
Jewish scientists
Alumni of Gonville and Caius College, Cambridge
Fellows of Gonville and Caius College, Cambridge
Members of the University of Cambridge Department of Chemistry
Academics of Imperial College London
Fellows of the Royal Society
Knights Bachelor
Foreign associates of the National Academy of Sciences
Members of the European Molecular Biology Organization
Fellows of the Academy of Medical Sciences (United Kingdom)
Royal Medal winners
English biophysicists
Masters of Gonville and Caius College, Cambridge
People educated at Sir George Monoux College
People from Walthamstow
Jewish chemists
Bijvoet Medal recipients
Recipients of the Copley Medal